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Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production.

Abstract：

:Eleven undescribed quinolone alkaloids, pesimquinolones I-S (1-4 and 6-12), as well as eleven known congeners (5 and 13-22), were isolated from the solid culture broth of the fungus Penicillium simplicissimum. Their chemical structures with absolute configurations were established by a combination of NMR spectroscopy, single-crystal X-ray crystallography, and modified Mosher's methods. Pesimquinolones I-K (1-3) represent the first examples of natural occurring quinolone alkaloids that possess a 6/6/6/6 tetracyclic ring system. The anti-inflammatory activities of selected compounds on LPS-induced nitric oxide (NO) production in adherent cells were evaluated. Compounds 1 and 2 showed suppressive effects on the production of NO, with IC50 values of 10.13 and 8.10 μM, respectively.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Dai C,Li X,Zhang K,Li XN,Wang W,Zang Y,Chen X,Li Q,Wei M,Chen C,Zhu H,Zhang Y

doi

10.1016/j.bioorg.2021.104635

subject

Has Abstract

pub_date

2021-01-08 00:00:00

pages

104635

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(21)00011-0

journal_volume

108

pub_type

杂志文章

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