Abstract:
:Carbamyl is considered a privileged structure in medicinal chemistry. It has a wide range of biological activities such as antimicrobial, anticancer, anti-epilepsy, for which the best evidence is a number of marketed carbamyl-containing drugs. Carbamyl is formed of primary amine and carbonyl moieties that act as hydrogen bond donors and hydrogen acceptors with residues of targets respectively, which are benefit for improving pharmacological activities. In other cases, the introduced carbamyl improves drug-like properties including oral bioavailability. In this review, we introduce the carbamyl-containing drugs and the application of carbamyl in structural optimization as a result of enhancing activities or/and drug-like properties.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Wang K,Zhu H,Zhao H,Zhang K,Tian Ydoi
10.1016/j.bioorg.2020.103757subject
Has Abstractpub_date
2020-05-01 00:00:00pages
103757eissn
0045-2068issn
1090-2120pii
S0045-2068(19)32117-0journal_volume
98pub_type
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