Application of carbamyl in structural optimization.

Abstract:

:Carbamyl is considered a privileged structure in medicinal chemistry. It has a wide range of biological activities such as antimicrobial, anticancer, anti-epilepsy, for which the best evidence is a number of marketed carbamyl-containing drugs. Carbamyl is formed of primary amine and carbonyl moieties that act as hydrogen bond donors and hydrogen acceptors with residues of targets respectively, which are benefit for improving pharmacological activities. In other cases, the introduced carbamyl improves drug-like properties including oral bioavailability. In this review, we introduce the carbamyl-containing drugs and the application of carbamyl in structural optimization as a result of enhancing activities or/and drug-like properties.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Wang K,Zhu H,Zhao H,Zhang K,Tian Y

doi

10.1016/j.bioorg.2020.103757

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

103757

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(19)32117-0

journal_volume

98

pub_type

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