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Bioactive sesquiterpene coumarins from the resin of Ferula sinkiangensis targeted on over-activation of microglia.

Abstract：

:Nine undescribed (1-4, 6-10) sesquiterpene coumarins, together with a new natural one (5) and ten known ones (11-20), were isolated from the low polarity fraction of the 95% ethanol extract of the resin of Ferula sinkiangensis. Their structures were elucidated based on the comprehensive analysis of HRESIMS, 1D and 2D NMR data. The absolute configurations were determined by comparison of experimental and calculated ECD spectra. All the identified SCs were evaluated for their anti-neuroinflammatory activities in LPS-induced BV-2 cells. Ferusingensine G (8) displayed a significant inhibitory effect on nitric oxide (NO) production with an IC50 value of 1.2 μM. The results suggested that natural SCs might be served as potential neuroinflammatory inhibitors.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Guo T,Zhou D,Yang Y,Zhang X,Chen G,Lin B,Sun Y,Ni H,Liu J,Hou Y,Li N

doi

10.1016/j.bioorg.2020.104338

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

104338

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31636-9

journal_volume

104

pub_type

杂志文章

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