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Synthesis and antioxidant activities of phenol derivatives from 1,6-bis(dimethoxyphenyl)hexane-1,6-dione.

Abstract：

:Starting from the compound (3,4-dimethoxyphenyl)(2-(3,4-dimethoxyphenyl)cyclopent-1-en-1-yl)methanone (4), two diols and three tetrol derivatives were synthesised. Morover, from the reactions of 1,3-dimethoxybenzene and 1,4-dimethoxybenzene with adipoyl chloride, fifteen new along with nine known compounds were obtained. For the characterizations of compounds, spectroscopic methods such as NMR including DEPT, COSY, HMQC and HMBC experiments and X-ray diffraction were used. The antioxidant activities of novel synthesized seventeen molecules were investigated by analytical methods like ABTS•+ and DPPH• scavenging. Also, reducing power these molecules were investigated by Fe3+, Cu2+, and [Fe3+-(TPTZ)2]3+. Some of the molecules record powerful antioxidant profile when compared to putative standards. The inhibition effects of the phenols compounds against AChE and BChE activities were analysed. Also, these phenols were found as effective inhibitors for AChE, hCA I, hCA II, and BChE with Kis in the range of 122.95 ± 18.41-351.31 ± 69.12 nM for hCA I, 62.35 ± 9.03-363.17 ± 180.1 nM for hCA II, 134.57 ± 3.99-457.43 ± 220.10 nM for AChE, and 27.06 ± 9.12-72.98 ± 9.53 nM for BChE, respectively.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Artunc T,Menzek A,Taslimi P,Gulcin I,Kazaz C,Sahin E

doi

10.1016/j.bioorg.2020.103884

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

103884

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)30292-3

journal_volume

100

pub_type

杂志文章

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