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Mycothiol: a promising antitubercular target.

Abstract：

:Tuberculosis (TB) is the world's second commonest cause of death next to HIV/AIDS. The increasing emergence of multi drug resistance and the recalcitrant nature of persistent infections pose an additional challenge for the treatment of TB. Due to the development of resistance to conventional antibiotics there is a need for new therapeutic strategies to combat M. tuberculosis. One such target is Mycothiol (MSH), a major low molecular-mass thiol in mycobacteria, an important cellular anti-oxidant. MSH is present only in actinomycetes and hence is a good target. This review explores mycothiol as a potential target against tuberculosis and various research ongoing worldwide.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Nilewar SS,Kathiravan MK

doi

10.1016/j.bioorg.2013.11.004

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

62-8

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(13)00074-6

journal_volume

52

pub_type

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