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Structural elucidation and anti-neuroinflammatory activities of lignans from the testas of Vernicia montana.

Abstract：

:Vernicia montana Lour. (tung tree) is an oil-producing plant with multiple uses, especially with its great potential in biodiesel production, which was a small Asian tree of the spurge family (Euphorbiaceae) with big economic values. However, studies on small molecular compositions of V. montana are limited. As a result, seven new lignans and one new coumacrin, and 21 known lignans, were isolated from the testas of V. montana. These isolates were confirmed in the light of spectroscopic tools (containing 1D and 2D NMR), ECD spectra methods. These isolates and crude extracts were evaluated their inhibitory activities using LPS-induced BV2 cells by assessing the NO production. Among them, compounds 3, 5, 6, 22 displayed significant effects, IC50 values about 11.4-20.9 μM. Together, the results demonstrated that lignans might be potential neuroinflammatory inhibitors.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Zhou D,Li Y,Chen G,Yang Y,Mi Y,Lin B,Li W,Hou Y,Li N

doi

10.1016/j.bioorg.2020.103690

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

103690

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)30093-6

journal_volume

97

pub_type

杂志文章

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