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Esterification of all four monoribonucleotides with acetyl-D-L-valine proceeds with a preference for the D-isomer but the D/L ratio in the products declines as a function of the hydrophobicity of the nucleotide.

Abstract：

:We recently reported that esterification of 5'-AMP with N-acetyl amino acids proceeds with a preference for D-amino acids, and the D/L ratio in products declines as the hydrophobicity of the amino acid declines. Using one amino acid, Ac-Val, we now show that esterification of all four nucleotides proceeds with a preference for the D-isomer and the preference declines as the hydrophobicity of the nucleotide declines. So, in both types of experiments, the preferences seem determined by hydrophobic interactions.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Wickramasinghe NS,Lacey JC Jr

doi

10.1016/0045-2068(92)90019-y

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

265-8

eissn

0045-2068

issn

1090-2120

journal_volume

20

pub_type

杂志文章

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