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Taxumarienes A-G, seven new α-glucosidase inhibitory taxane-diterpenoids from the leaves of Taxus mairei.

Abstract：

:Seven new taxane diterpenoids taxumarienes A-G (1-7) were isolated from the leaves of Taxus mairei, along with seven known analogous (8-14). The structures of the new compounds were elucidated based on the analysis of NMR and MS spectroscopy. All isolates were evaluated for their α-glucosidase inhibitory activities. Among them, taxumarienes A (1) and F (6) showed potent effect with IC50 values of 5.9 ± 1.30 μM and 3.7 ± 0.75 μM, respectively.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Chen K,Liu XQ,Wang WL,Luo JG,Kong LY

doi

10.1016/j.bioorg.2019.103400

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

103400

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(19)31433-6

journal_volume

94

pub_type

杂志文章

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