Abstract:
:Simple biomembrane models, namely micellar aggregates formed by enantiopure sodium N-acylprolinates, are able to convert the racemic mixture of bilirubin-IXalpha into an enantiomerically enriched mixture, thus suggesting a possible role of chirality in bilirubin toxicity due to the perturbation of neuron membrane dynamics. The length of alkyl chain does not influence the extent of equilibrium displacement, however, it affects the conformation of bilirubin, thus confirming the role of lipid structure in the membrane/bilirubin interaction, and suggesting a non-superficial main site of association.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Ceccacci F,Giansanti L,Mortera SL,Mancini G,Sorrenti A,Villani Cdoi
10.1016/j.bioorg.2008.05.001subject
Has Abstractpub_date
2008-10-01 00:00:00pages
252-4issue
5eissn
0045-2068issn
1090-2120pii
S0045-2068(08)00025-4journal_volume
36pub_type
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