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Exploring the interaction between citrus flavonoids and phytopathogenic fungi through enzymatic activities.

Abstract：

:Flavonoids are involved in citrus defense against phytopathogens. In this study, we applied in vitro biocatalysis assays using the flavanones glycosides hesperidin and naringin to explore the enzymatic activities involved in such interaction. The main enzymatic activity observed was the hydrolysis catalyzed by fungi naringinases and hesperidinases. Withing 7 days, the two citrus phytopathogenic fungi, Penicillium digitatum and Penicillium italicum, exhibited the highest hydrolyzing rate on the flavanones, reaching conversion values higher than 90%. In addition, Geothrichum citri-aurantii exhibited no enzymatic activity and Penicillium expansum only hydrolyzed hesperidin. In order to evaluate flavonoid biotransformation by the fungi in vivo, citrus fruits infected with P. digitatum were analyzed through molecular networking and Imaging Mass Spectrometry (IMS). In vivo assays revealed that citrus fruit in response to the infection is able to hydroxylate flavonoids, and novel flavonoid structures were associated to the citrus' defense. The data reported here present a new point of view in the relation between citrus flavonoids and phytopathogenic fungi and can be useful to understand the infection processes and host-pathogen interaction.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Costa JH,Fernandes LS,Akiyama DY,Fill TP

doi

10.1016/j.bioorg.2020.104126

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

104126

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31423-1

journal_volume

102

pub_type

杂志文章

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