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Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways.

Abstract：

:Lambertellin (1) and ergosta-5,7,22-trien-3-ol (2) were isolated from the solid rice fermentation of the plant pathogenic fungus Pycnoporus sanguineus MUCL 51321. Their structures were elucidated using comprehensive spectroscopic methods. The isolated compounds were tested on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Lambertellin (1) exhibited promising inhibitory activity against nitric oxide (NO) production with IC50 value of 3.19 µM, and it significantly inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). Lambertellin (1) also decreased the expression of pro-inflammatory cytokines IL-6 and IL-1β. The study of the mechanistic pathways revealed that lambertellin (1) exerts its anti-inflammatory effect in LPS-stimulated RAW 264.7 macrophage cells by modulating the activation of the mitogen activated protein kinase (MAPK) and nuclear factor κB (NF-κB) signaling pathways. Therefore, lambertellin (1) could be a promising lead compound for the development of new anti-inflammatory drugs.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Jouda JB,Mfotie Njoya E,Mbazoa CD,Zhou Z,Meli Lannang A,Wandji J,Shiono Y,Wang F

doi

10.1016/j.bioorg.2018.06.021

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

216-222

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)30417-6

journal_volume

80

pub_type

杂志文章

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