Abstract：
:Seven flavonoid dimers, biflavocochins A-G, together with six known compounds were isolated from the red resins of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1-7 was assigned by experimental and quantum chemical calculated ECD spectra, and that of 4 was further established by X-ray diffraction analysis using Cu Kα radiation. Compounds 1-3 are novel dimers of homoisoflavonoid and dihydrochalcone with a unique dibenzopyran ring. Compounds 2, 6, 7 exhibited moderate PTP1B inhibitory activities in an enzyme assay. Compound 1 showed neuroprotective effect on serum deficiency-induced cellular damage in PC12 cells.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Lang GZ,Li CJ,Gaohu TY,Li C,Ma J,Yang JZ,Zhou TT,Yuan YH,Ye F,Wei JH,Zhang DMdoi
10.1016/j.bioorg.2020.103659subject
Has Abstractpub_date
2020-04-01 00:00:00pages
103659eissn
0045-2068issn
1090-2120pii
S0045-2068(19)31114-9journal_volume
97pub_type
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