Research progress in biological activities of succinimide derivatives.

Abstract:

:Succinimides are well recognized heterocyclic compounds in drug discovery which produce diverse therapeutically related applications in pharmacological practices. Researches in medicinal chemistry field have isolated and synthesized succinimide derivatives with multiple medicinal properties including anticonvulsant, anti-inflammatory, antitumor and antimicrobial agents, 5-HT receptor ligands and enzyme inhibitors. Simultaneously, SAR (Structure-Activity Relationship) analysis has been gradually possessed, along with a great deal of derivatives have been derived for potential targets. In this article, we comprehensively summarize the biological activities and SAR for succinimide derivatives, along with the featuring bioactive molecules reported in patents, wishing to provide an overall retrospect and prospect on the succinimide analogues.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Zhao Z,Yue J,Ji X,Nian M,Kang K,Qiao H,Zheng X

doi

10.1016/j.bioorg.2020.104557

subject

Has Abstract

pub_date

2020-12-15 00:00:00

pages

104557

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31855-1

pub_type

杂志文章,评审