Abstract：
:Succinimides are well recognized heterocyclic compounds in drug discovery which produce diverse therapeutically related applications in pharmacological practices. Researches in medicinal chemistry field have isolated and synthesized succinimide derivatives with multiple medicinal properties including anticonvulsant, anti-inflammatory, antitumor and antimicrobial agents, 5-HT receptor ligands and enzyme inhibitors. Simultaneously, SAR (Structure-Activity Relationship) analysis has been gradually possessed, along with a great deal of derivatives have been derived for potential targets. In this article, we comprehensively summarize the biological activities and SAR for succinimide derivatives, along with the featuring bioactive molecules reported in patents, wishing to provide an overall retrospect and prospect on the succinimide analogues.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Zhao Z,Yue J,Ji X,Nian M,Kang K,Qiao H,Zheng Xdoi
10.1016/j.bioorg.2020.104557subject
Has Abstractpub_date
2020-12-15 00:00:00pages
104557eissn
0045-2068issn
1090-2120pii
S0045-2068(20)31855-1pub_type
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