Abstract：
:As a part of our continuing search for bioactive constituents from Brassicaceae family, three new bis-thioglycosides (1-3) were isolated from the 80% MeOH extract of Nasturtium officinale, together with 13 known compounds (4-16). The chemical structures of three new bis-thioglycosides (1-3) were elucidated using NMR techniques (1H and 13C NMR, 1H-1H COSY, HSQC, and HMBC), HRESIMS, and a chemical method. All the compounds were evaluated for their inhibitory effects on nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Among the isolates, compound 5 exhibited a strong inhibitory effect on NO production, and compounds 4 and 15 showed moderate inhibitory activities, suggesting the neuroprotective and anti-neuroinflammatory effects of bis-thioglycosides from N. officinale.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Lee TH,Khan Z,Subedi L,Kim SY,Lee KRdoi
10.1016/j.bioorg.2019.01.062subject
Has Abstractpub_date
2019-05-01 00:00:00pages
501-506eissn
0045-2068issn
1090-2120pii
S0045-2068(18)31190-8journal_volume
86pub_type
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更新日期：2021-01-01 00:00:00
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