Abstract:
BACKGROUND:We examined the effects of cytochrome P450 2C19 (CYP2C19) polymorphisms on the efficacy and safety of prasugrel and clopidogrel in a post hoc analysis of the PRASugrel compared with clopidogrel For Japanese patIenTs with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) (PRASFIT-ACS) study. METHODS:Japanese ACS patients undergoing PCI were randomized (double-blind) to receive prasugrel (loading/maintenance dose: 20/3.75mg) or clopidogrel (300/75mg) plus aspirin for 24-48 weeks. Pharmacogenomic analyses were conducted in 773/1363 patients. P2Y12 reaction units (PRU) were determined using the VerifyNow(®) P2Y12 assay (Accumetrics, San Diego, CA, USA). CYP2C19 genotypes were classified as extensive metabolizers (EM), intermediate metabolizers (IM), and poor metabolizers (PM). RESULTS:Overall, 39.2% and 60.8% of patients in the prasugrel group and 35.2% and 64.8% of patients in the clopidogrel group were classified as EM and IM+PM, respectively. Among EM patients, PRU was significantly lower in the prasugrel group than in the clopidogrel group at 2-4 and 5-12h after the loading dose, but was similar in both groups from week 4 onwards. Among IM+PM patients, PRU was significantly lower in the prasugrel group than in the clopidogrel group throughout the study. Among EM patients, the incidence of major adverse cardiovascular events (MACE) at 24 weeks was 11.8% in the prasugrel group and 11.9% in the clopidogrel group [hazard ratio (HR): 0.99, 95% confidence interval (CI): 0.50-1.96]. Among IM+PM patients, the incidence of MACE was 9.3% in the prasugrel group and 12.5% in the clopidogrel group (HR: 0.78, 95% CI: 0.45-1.35). The incidences of major, minor, and clinically relevant bleeding were similar between the two groups for each genotype. CONCLUSIONS:Prasugrel showed more consistent antiplatelet effects than clopidogrel in Japanese ACS patients irrespective of the CYP2C19 phenotype.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Ogawa H,Isshiki T,Kimura T,Yokoi H,Nanto S,Takayama M,Kitagawa K,Nishikawa M,Miyazaki S,Ikeda Y,Nakamura M,Tanaka Y,Saito Sdoi
10.1016/j.jjcc.2015.07.019subject
Has Abstractpub_date
2016-07-01 00:00:00pages
29-36issue
1eissn
0914-5087issn
1876-4738pii
S0914-5087(15)00242-7journal_volume
68pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Myocardial fibrosis is the major factor that regulates left ventricular (LV) diastolic function. Pioglitazone, an anti-diabetic drug, is reported to improve the LV diastolic function in diabetic patients, but its influence on myocardial fibrosis has not been clarified. We evaluated the effect of pioglitazone...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2009.03.004
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To determine which improves clinical outcomes more, sutureless (including rapid-deployment) aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI), we performed a meta-analysis of comparative studies. METHODS:MEDLINE and EMBASE were searched through June 2015 using Web-based search...
journal_title:Journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.jjcc.2015.09.009
更新日期:2016-06-01 00:00:00
abstract::Coronary flow velocity recordings were obtained in three patients with ampulla (Takotsubo) cardiomyopathy using Doppler guide wire. Immediately after admission, coronary angiography demonstrated no significant stenosis and normal coronary flow in the epicardial coronary artery. Left ventriculography showed abnormal wa...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Four patients with acute myocardial infarction (MI) complicating double rupture; interventricular septum and ventricular free wall ruptures, were studied. All patients had histories of hypertension, and pre-infarction angina pectoris of short duration less than 8 days without previous MI. The sites of infarction were ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The relationship between myocardial contrast echocardiography and improvement of the left ventricular wall motion was studied as an indicator of the prognosis of patients with acute myocardial infarction. Ten patients with acute anterior myocardial infarction who demonstrated successful reperfusion (improved to TIMI g...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::Coronary (artery) spasm plays an important role in the pathogenesis of ischemic heart disease, including stable angina, unstable angina, myocardial infarction, and sudden death. The prevalence of coronary spasm differs among populations, is higher in Japan and Korea than in the Western countries probably due to geneti...
journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2008.01.001
更新日期:2008-02-01 00:00:00
abstract::Vaccines are primarily used worldwide as a preventive medicine for infectious diseases and have recently been applied to cancer. We and others have developed therapeutic vaccines designed for cardiovascular diseases that are notably different from previous vaccines. In the case of cancer vaccines, a specific protein i...
journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2017.01.010
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Puerarin is the most abundant isoflavonoid in kudzu root. It has been used to treat angina pectoris and myocardial infarction clinically. However, little is known about the effect of puerarin on cardiac hypertrophy. METHODS:Aortic banding (AB) was performed to induce cardiac hypertrophy in mice. Puerarin pr...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.06.008
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Elevated levels of total plasma adiponectin (APN) and high molecular weight (HMW)-APN have been observed in chronic heart failure (HF) and are associated with poor prognosis, however, the response of APN levels in acute HF is not known. The purpose of this study was to clarify the dynamic changes of the plas...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2011.06.010
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a se...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2011.04.005
更新日期:2011-09-01 00:00:00
abstract::The efficacy of catheter intervention for adult congenital heart diseases was evaluated in 27 patients aged 20 to 52 years (mean age at catheterization 25 +/- 7 years) from 1986 to 1996. Four patients had pulmonary valve stenosis, four had aortic valve stenosis, three had coarctation of the aorta, 10 had pulmonary art...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Little is known about the efficacy and safety of intensive lowering of low-density lipoprotein cholesterol (LDL-C) with statin/ezetimibe therapy after coronary stent implantation in patients with stable angina. Fifty patients with stable angina were randomly divided into an atorvastatin (10 mg/day) (A) group and an at...
journal_title:Journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jjcc.2012.03.002
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Although tolvaptan is a recently approved drug for heart failure and causes aquaresis without affecting renal function, its clinical efficacy for patients with acute decompensated heart failure (ADHF) is yet to be elucidated. METHODS AND RESULTS:We conducted a prospective observational study in patients wit...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.08.020
更新日期:2013-02-01 00:00:00
abstract::Numerous epidemiological and animal studies disclosed that birth weight is inversely associated with the incidence of the lifestyle-related disorders in adult life, such as cardiovascular disease, diabetes, and /or chronic kidney disease. Lower birth weight occurs in numerous undesired intrauterine environments includ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2020.02.003
更新日期:2020-07-01 00:00:00
abstract::There have been several case reports, a total of 22 up to the present, of toxoplasma pericarditis. Out of them, in only a few cases the diagnosis was properly made with a proof of the microscopic presence of Toxoplasma gondii. This is the first report of toxoplasma pericarditis in which the presence of Toxoplasma gond...
journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::Ischemic heart disease is the leading cause of morbidity and mortality in a worldwide epidemic. Myocardial ischemia is characterized by an imbalance between myocardial oxygen supply and demand, causing cardiac dysfunction, arrhythmias, myocardial infarction, and sudden death. Various clinical ischemic manifestations a...
journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2008.07.016
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:Rapid mobilization and discharge following rapid acute phase reperfusion are recommended for elderly patients with acute myocardial infarction to achieve a better outcome and performance. The safety and efficacy of new and old treatment protocols were retrospectively compared for patients with acute myocardi...
journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:Brain natriuretic peptide (BNP) and QRS duration have been reported as independent predictors for cardiac events in patients with heart failure. The present study investigated the relationships between BNP and QRS duration to assess the prognostic value in patients with heart failure. METHODS:We prospective...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::Endoventricular circular patch plasty (Dor operation) was used to treat end-stage dilated ischemic cardiomyopathy in 13 patients from January to December, 1997. There were 10 men and three women aged from 57 to 78 years (mean 63 years). Single, double, triple and left main trunk coronary disease was present in one, tw...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::To assess tricuspid regurgitation (TR) in patients with permanent transvenous right ventricular (RV) pacing, we performed phonocardiographic, contrast and pulsed Doppler echocardiographic studies in 18 patients with transvenous leads for RV pacing. In addition, a pathological study was performed on 26 autopsy cases wi...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract:PURPOSE:Cholinergic nerve plays an important role in the induction and maintenance of atrial fibrillation (AF). Cholinergic innervation at supraventricular tissues is considered to be the histological basis and intervention-associated target site for the arrhythmia; however, the distribution of cholinergic nerve in sup...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.12.003
更新日期:2013-03-01 00:00:00
abstract::The mortality and morbidity associated with residual intracardiac floating thrombi in patients with acute pulmonary thromboembolism remain uncertain. Thirteen patients (2 men and 11 women, mean age 56 +/- 15 years) with pulmonary thromboembolism underwent echocardiography within 24 hours from onset of symptoms. Four p...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:Although physicians frequently perform palpation of the apex beat to evaluate left ventricular (LV) size and hypertrophy, the clinical significance of apex beat palpation is still unclear. The introduction of multislice computed tomography (MSCT) has enabled assessment not only of coronary stenoses but also ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2009.11.008
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have elevated bleeding and ischemic outcomes. We aim to assess the short- and long-term efficacy and safety of bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPIs) in coronary artery disease (CAD) patients with CKD. METHODS:Randomized trials...
journal_title:Journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.jjcc.2017.10.018
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Inflammation and oxidative stress play a role in the pathophysiology of chronic heart failure (CHF). Our previous clinical trial, the Bisoprolol Improvement Group for Chronic Heart Failure Treatment Study in Dokkyo Medical University (BRIGHT-D), reported that bisoprolol is superior to carvedilol for myocardi...
journal_title:Journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jjcc.2019.07.011
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:We conducted the present study to determine the level of physical activity required to retard the progression of carotid intima-media thickness (IMT) in patients with coronary heart disease (CHD). PATIENTS AND MAIN OUTCOME MEASUREMENTS:The daily walking distance (km/day) of 40 patients with CHD (male/female ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.02.005
更新日期:2008-06-01 00:00:00
abstract::To determine right (RV) and left ventricular (LV) volumes, a new technique was developed using ECG-gated single-photon emission computed tomography (SPECT). RV volumes of nine patients and LV volumes of 22 patients measured by SPECT and biplane contrast cineangiography were compared. In addition, volume and ejection f...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Ischemic "pre"-conditioning has been shown to have antiarrhythmic effects. The aim of this study was to investigate whether ischemic "post"-conditioning (post-CON) also has antiarrhythmic effects in ST-segment elevation myocardial infarction (STEMI) patients undergoing coronary angioplasty (PCI) as a clinica...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2011.05.002
更新日期:2011-09-01 00:00:00
abstract::A 76-year-old woman was admitted to our hospital with cardiac tamponade. Chest computed tomography revealed a large tumor adjacent to the pulmonary artery, the center of which was demonstrated as a high density area without contrast medium. Coronary angiography revealed a large aneurysm consisting of coronary artery f...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Eleven directional coronary atherectomy procedures were performed in seven patients with angina pectoris and four patients with myocardial infarction, 10 men and 1 woman aged 41 to 69 years (mean 57 +/- 7 years). The onset of angina pectoris or myocardial infarction had occurred 2 months to 17 years previously. The pr...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00