Abstract:
BACKGROUND:Patients with chronic kidney disease (CKD) have elevated bleeding and ischemic outcomes. We aim to assess the short- and long-term efficacy and safety of bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPIs) in coronary artery disease (CAD) patients with CKD. METHODS:Randomized trials were searched in PubMed, Cochrane, and Embase databases up to January 2017. Among the trials retrieved, efficacy endpoints were defined as mortality, myocardial infarction (MI), repeat revascularization, stent thrombosis, and major adverse cardiac events (MACEs). Safety endpoints were reported as non-coronary artery bypass grafting (CABG) related major bleeding and thrombolysis in myocardial infarction (TIMI) major bleeding. Risk ratio (RR) and 95% confidence interval (CI) were calculated for each outcome using a fixed effect model. RESULTS:Five studies with a total of 3796 patients were included. In short-term follow up (30 days), bivalirudin significantly reduced non-CABG related major bleeding (p=0.0004) and TIMI major bleeding (p=0.007) compared to heparin plus GPIs. No significant differences were observed in rates of mortality, MI, repeat revascularization, stent thrombosis, and MACEs between the two groups in short- and long-term follow up (6 months to 3 years). In patients with ST elevated myocardial infarction (STEMI) with concurrent CKD, the decreased non-CABG related major bleeding (p=0.04) without increasing ischemic events was also observed after short-term follow up. CONCLUSIONS:(1) Bivalirudin is safer than and as effective as heparin plus GPIs in CAD patients with CKD. (2) Impaired renal function does not affect the safety benefits of bivalirudin. (3) Similar efficacy profiles were identified between the two groups after both short- and long-term follow up in the CAD patients with CKD.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Zeng X,Lincoff AM,Schulz-Schüpke S,Steg PG,Elbez Y,Mehran R,Stone GW,McAndrew T,Lin J,Zhang X,Shi W,Lei H,Jing Z,Huang Wdoi
10.1016/j.jjcc.2017.10.018subject
Has Abstractpub_date
2018-05-01 00:00:00pages
494-504issue
5eissn
0914-5087issn
1876-4738pii
S0914-5087(17)30309-Xjournal_volume
71pub_type
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abstract::Heart failure (HF) occurs across the entire range of left ventricular (LV) ejection fractions (EF), not just reduced EF. Nearly half or more patients presenting with HF have a preserved EF>0.50 (HFpEF). Diastolic dysfunction is apparent in all patients with HF, regardless of EF. A preserved EF indicates that the end-d...
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journal_title:Journal of cardiology
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journal_title:Journal of cardiology
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更新日期:2007-07-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2008.07.016
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.12.010
更新日期:2013-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2019.02.017
更新日期:2019-07-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.07.007
更新日期:2013-11-01 00:00:00
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journal_title:Journal of cardiology
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doi:
更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Journal of cardiology
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doi:10.1016/j.jjcc.2012.01.006
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.06.008
更新日期:2009-02-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.02.005
更新日期:2008-06-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.08.013
更新日期:2014-04-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2016.09.003
更新日期:2017-07-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2005-12-01 00:00:00