[Efficacy of intravenous myocardial contrast echocardiography for assessment of perfusion area of the heart in mice].

Abstract:

BACKGROUND AND OBJECTIVES:Intravenous myocardial contrast echocardiography is used clinically, but use in small animals has not been evaluated. The conditions for myocardial opacification and the feasibility of myocardial contrast echocardiography were examined in mice. METHODS:Closed chest mice were examined. The left ventricular short-axis view at the mid papillary muscle level was recorded before and after NC100100 injection using a SONOS 5500 (PHILIPS). Real time and intermittent triggering (every 5 beats) myocardial contrast echocardiography was performed with a mechanical index of low (0.3), middle (0.7), and high (1.5). Open chest mice were examined after left anterior descending coronary artery ligation. Myocardial contrast echocardiography was performed using intermittent triggering imaging (every 5 beats) with high mechanical index (1.5). The ratio of the non-perfused area to the whole left ventricular wall area was compared with that of the non-stained area by Evans Blue. RESULTS:The left ventricular myocardium was opacified in any setting. Good opacification was acquired at middle mechanical index (0.7) in real time myocardial contrast echocardiography and at high mechanical index (1.5) in intermittent myocardial contrast echocardiography. The opacified and non-opacified myocardium were clearly identified in all mice with coronary ligation. The non-opacified area ratio showed a good correlation with the non-stained area ratio (y = 0.93x + 0.51, r = 0.94, p < 0.05). CONCLUSIONS:Myocardial contrast echocardiography can be used to assess myocardial perfusion and determine the ischemic area accurately in situ in the mouse.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Hirayama H,Ishikura F,Okuda K,Hirano T,Kobayashi H,Beppu S

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

213-9

issue

5

eissn

0914-5087

issn

1876-4738

journal_volume

42

pub_type

杂志文章
  • Meta-analysis of transcatheter aortic valve implantation for bicuspid versus tricuspid aortic valves.

    abstract:BACKGROUND:We performed meta-analysis and meta-regression of transcatheter aortic valve implantation (TAVI) for the bicuspid aortic valve (B-AV) versus the tricuspid aortic valve (T-AV). METHODS:MEDLINE and EMBASE were searched through June 2018 using PubMed and OVID. We included comparative studies of TAVI patients w...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jjcc.2019.03.018

    authors: Takagi H,Hari Y,Kawai N,Kuno T,Ando T,ALICE (All-Literature Investigation of Cardiovascular Evidence) Group.

    更新日期:2019-07-01 00:00:00

  • [Clinical usefulness of transesophageal Doppler echocardiography].

    abstract::The usefulness of transesophageal Doppler echocardiography (TEE) was assessed in patients with various cardiovascular diseases including 15 patients with dissecting aortic aneurysm (DAA), two with thoracic aneurysm, 16 with ischemic heart disease and 14 with acquired valvular diseases. In dissecting aortic aneurysms, ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Hashimoto S,Kumada T,Osakada G,Tokunaga S,Kubo S,Aoshima M,Tamaki S,Yamazato A,Ban T,Kawai C

    更新日期:1990-01-01 00:00:00

  • [Clinical significance of early percutaneous coronary intervention in patients with Braunwald III-B type unstable angina pectoris].

    abstract:OBJECTIVES:To assess the efficacy of early invasive strategy for the treatment of Braunwald III-B type unstable angina pectoris. METHODS:This study included 573 consecutive patients of whom 267 underwent percutaneous coronary intervention (PCI) (312 lesions). The patients were divided into two groups, 95 treated with ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Nozaki K,Nakao K,Horiuchi K,Kasanuki H,Honda T

    更新日期:2003-06-01 00:00:00

  • Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention.

    abstract:BACKGROUND:Heart failure (HF) is a risk factor for adverse post-procedural outcome after revascularization; however, it is unclear how left ventricular systolic dysfunction (LVSD) and clinical HF symptoms affect percutaneous coronary intervention (PCI) outcomes. We investigated the characteristics and long-term outcome...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2020.06.014

    authors: Kimura M,Kohno T,Sawano M,Heidenreich PA,Ueda I,Takahashi T,Matsubara T,Ueno K,Hayashida K,Yuasa S,Ohki T,Fukuda K,Kohsaka S

    更新日期:2021-01-01 00:00:00

  • Plasma kinetics of mature PCSK9, furin-cleaved PCSK9, and Lp(a) with or without administration of PCSK9 inhibitors in acute myocardial infarction.

    abstract:BACKGROUND:There are two types of circulating proprotein convertase subtilisin/kexin type 9 (PCSK9), mature and furin-cleaved. Most types of lipoprotein(a) [Lp(a)], an independent risk factor of cardiovascular events, bind to mature PCSK9. OBJECTIVE:This study examined the effects of monoclonal anti-PCSK9 antibody on ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2020.04.006

    authors: Nakamura A,Kanazawa M,Kagaya Y,Kondo M,Sato K,Endo H,Nozaki E

    更新日期:2020-10-01 00:00:00

  • Percutaneous revascularization of coronary chronic total occlusion: Toward a reappraisal of the available evidence.

    abstract::Chronic total occlusion (CTO) is a challenging subset of coronary artery disease that is commonly encountered in real-world practice; it is associated with worse long-term prognosis. Observational studies suggest that percutaneous coronary intervention (PCI) for CTO is associated with reduction in myocardial ischemia ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jjcc.2016.12.006

    authors: Karjalainen PP,Nammas W

    更新日期:2017-06-01 00:00:00

  • [Concentric left ventricular hypertrophy in patients with aortic regurgitation].

    abstract::Chronic aortic regurgitation (AR) is a disease incorporating volume overload of the left ventricle (LV) which is characterized by hyperactive left ventricular dilatation (LVD). However, we have encountered several patients who had concentric LV hypertrophy (LVH) instead of LVD. We therefore studied 50 consecutive pati...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Nishi H,Imawatari R,Chiba M,Koga Y,Toshima H

    更新日期:1989-12-01 00:00:00

  • Comparison of heart rate reduction effect and safety between bisoprolol transdermal patch and bisoprolol fumarate oral formulation in Japanese patients with persistent/permanent atrial fibrillation (BISONO-AF study).

    abstract:BACKGROUND:TY-0201 (TY) is a transdermal patch containing bisoprolol. The objectives of this study were to evaluate the noninferiority of TY to bisoprolol oral formulation (BO) in patients with persistent or permanent atrial fibrillation (AF). METHODS:In this multicenter, double-blind, comparative study, Japanese pati...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jjcc.2018.11.009

    authors: Yamashita T,Ikeda T,Akita Y

    更新日期:2019-05-01 00:00:00

  • Long-term adherence to nasal continuous positive airway pressure therapy by hypertensive patients with preexisting sleep apnea.

    abstract:BACKGROUND AND OBJECTIVE:Although positive screening for and treatment of obstructive sleep apnea (OSA) have been recommended for patients with cardiovascular problems, patient adherence to nasal continuous positive airway pressure (CPAP) therapy primarily for a cardiovascular concern is unknown. Therefore, this study ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2013.08.013

    authors: Furukawa T,Suzuki M,Ochiai M,Kawashima H,Yokoyama N,Isshiki T

    更新日期:2014-04-01 00:00:00

  • Efficacy and safety of bivalirudin in coronary artery disease patients with mild to moderate chronic kidney disease: Meta-analysis.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have elevated bleeding and ischemic outcomes. We aim to assess the short- and long-term efficacy and safety of bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPIs) in coronary artery disease (CAD) patients with CKD. METHODS:Randomized trials...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jjcc.2017.10.018

    authors: Zeng X,Lincoff AM,Schulz-Schüpke S,Steg PG,Elbez Y,Mehran R,Stone GW,McAndrew T,Lin J,Zhang X,Shi W,Lei H,Jing Z,Huang W

    更新日期:2018-05-01 00:00:00

  • Comparison of post-stent irregular protrusion and subsequent neointimal characteristics between second- and third-generation drug-eluting stent implantation.

    abstract:BACKGROUND:Third-generation drug-eluting-stents (3rd DES) may improve coronary arterial healing and reduce neoatherosclerosis formation. We evaluated post-stent findings and subsequent vascular healing of 3rd DES by comparing to second-generation drug-eluting-stents (2nd DES) at intermediate-term follow-up using optica...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2020.05.013

    authors: Miura T,Sonoda S,Sanuki Y,Naka Y,Okabe H,Setoyama K,Inoue K,Shimizu A,Anai R,Tsuda Y,Araki M,Otsuji Y

    更新日期:2020-11-01 00:00:00

  • [Hypertrophic obstructive cardiomyopathy with ruptured mitral chordae tendineae: a case report].

    abstract::A 61-year-old man was treated medically under a diagnosis of hypertrophic obstructive cardiomyopathy 7 years previously. He was transferred to our hospital because of sudden onset of dyspnea. Chest radiography showed marked pulmonary congestion. Echocardiography revealed hypertrophic obstructive cardiomyopathy, with a...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Wakeyama T,Ogawa H,Takaki A,Iwami T,Kimura M,Tanaka T,Uchinoumi H

    更新日期:2004-08-01 00:00:00

  • Impact of obstructive sleep apnea on left atrial functional and structural remodeling beyond obesity.

    abstract:BACKGROUND:To evaluate the left atrial (LA) volume and function of obese patients with/without obstructive sleep apnea (OSA) and its association with left ventricular (LV) diastolic function independent of obesity. METHODS:LA volumetric and functional parameters were measured by 2-dimensional and strain echocardiograp...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2012.07.007

    authors: Kim SM,Cho KI,Kwon JH,Lee HG,Kim TI

    更新日期:2012-12-01 00:00:00

  • The association between impaired collateral circulation and non-alcoholic fatty liver in patients with severe coronary artery disease.

    abstract:BACKGROUND AND PURPOSE:Coronary collateral circulation (CCC) has been demonstrated to be impaired in patients with type 2 diabetes mellitus which is characterized by insulin resistance. In this study, our purpose was to find out a possible relationship between CCC and non-alcoholic fatty liver disease (NAFLD), which is...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2012.05.003

    authors: Arslan U,Kocaoğlu I,Balcı M,Duyuler S,Korkmaz A

    更新日期:2012-09-01 00:00:00

  • Better stent expansion by two-time inflation of stent balloon and its responsible mechanism.

    abstract:OBJECTIVES:We determined the effect of two-time inflation of the stent balloon on stent expansion and its responsible factor. METHODS:Subjects included 61 patients with de novo coronary artery lesions, in whom 12 sirolimus-eluting, 27 paclitaxel-eluting, and 22 other stents were deployed twice at identical inflation p...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2011.12.003

    authors: Iwamoto Y,Okamoto M,Hashimoto M,Fukuda Y,Iwamoto A,Iwasaki T,Kinoshita H,Kihara Y

    更新日期:2012-03-01 00:00:00

  • Association between sleep apnea and overnight hemodynamic changes in hospitalized heart failure patients with and without paroxysmal nocturnal dyspnea.

    abstract:BACKGROUND:Paroxysmal nocturnal dyspnea (PND) is a common symptom for patients with acute decompensated heart failure (ADHF). Some symptoms of PND are similar to those of sleep apnea (SA) which might be associated with overnight worsening hemodynamics in failing hearts. However, the association between PND, SA, and ove...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2012.12.010

    authors: Yagishita-Tagawa Y,Yumino D,Takagi A,Serizawa N,Hagiwara N

    更新日期:2013-05-01 00:00:00

  • Factors affecting in-hospital mortality and likelihood of undergoing surgical resection in patients with primary cardiac tumors.

    abstract:BACKGROUND:Previous studies on primary cardiac tumors were mainly based on small case series collected from a limited number of institutions. Contemporary data of patients with primary cardiac tumors treated with or without surgery in a nationwide clinical setting are limited. METHODS:Using the Diagnosis Procedure Com...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2016.05.008

    authors: Isogai T,Yasunaga H,Matsui H,Tanaka H,Hisagi M,Fushimi K

    更新日期:2017-01-01 00:00:00

  • Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a predictive marker of cardiovascular events in patients with stable angina pectoris. However, little is known about this marker in patients with acute coronary syndrome (ACS). We investigated the prognostic relevance of MDA-LDL to cardiovascular ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2019.02.012

    authors: Amioka N,Miyoshi T,Otsuka H,Yamada D,Takaishi A,Ueeda M,Hirohata S,Ito H

    更新日期:2019-09-01 00:00:00

  • Incidence, retrieval methods, and outcomes of intravascular ultrasound catheter stuck within an implanted stent: Systematic literature review.

    abstract:BACKGROUND:There have been no reviews regarding intravascular ultrasound (IVUS) catheter entrapment during percutaneous coronary intervention (PCI). This study investigated the incidence, retrieval methods, and outcomes of IVUS catheter stuck within implanted stents. METHODS:Between January 2015 and July 2018, a total...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2019.07.005

    authors: Hiraya D,Sato A,Hoshi T,Sakai S,Watabe H,Ieda M

    更新日期:2020-02-01 00:00:00

  • Bleeding risks associated with anticoagulant therapies after percutaneous coronary intervention in Japanese patients with ischemic heart disease complicated by atrial fibrillation: A comparative study.

    abstract:BACKGROUND:Current guidelines recommend early termination of triple therapy and the use of direct oral anticoagulants (DOAC) for non-valvular atrial fibrillation (NVAF) patients who undergo percutaneous coronary intervention (PCI), due to safety concerns. However, to date, real-world medication usage and safety outcome...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2020.08.008

    authors: Nakamura M,Yamashita T,Hayakawa A,Matsumoto T,Takita A,Hasegawa C,Uchino K,Sekine T,Iizuka T,Tanabe H,Kogure S

    更新日期:2021-02-01 00:00:00

  • Factors influencing left atrial volume in treated hypertension.

    abstract:BACKGROUND:Left atrial (LA) enlargement has been documented to occur in hypertension (HT), and has been an index for evaluating the diastolic function of the left ventricle. Enlargement of the LA is one of the vital factors that induce heart failure and atrial fibrillation (AF) in patients with HT. METHODS AND SUBJECT...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jjcc.2012.02.011

    authors: Chen Y,Sato H,Watanabe N,Adachi T,Kodani N,Sato M,Takahashi N,Kitamura J,Sato H,Yamaguchi K,Yoshitomi H,Tanabe K

    更新日期:2012-08-01 00:00:00

  • Recovery of atrioventricular block following steroid therapy in patients with cardiac sarcoidosis.

    abstract:BACKGROUND:Atrioventricular (AV) block is one of the main clinical manifestations in patients with cardiac sarcoidosis (CS). Although steroid therapy is considered to be effective for AV block, the efficacy has not been demonstrated in detail. METHODS AND RESULTS:Fifteen CS patients presenting with advanced or complet...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2013.07.007

    authors: Yodogawa K,Seino Y,Shiomura R,Takahashi K,Tsuboi I,Uetake S,Hayashi H,Horie T,Iwasaki YK,Hayashi M,Miyauchi Y,Shimizu W

    更新日期:2013-11-01 00:00:00

  • [Tricuspid regurgitation in mitral valve prolapse studied by two-dimensional color flow mapping].

    abstract::To assess the incidence of tricuspid regurgitation (TR) in mitral valve prolapse (MVP), 96 patients with MVP and 23 normal control subjects were studied. Subjects in the MVP group were further classified as a group with mitral regurgitation (MR(+) group: 61 cases), and MR(-) group (35 cases). The presence of TR in eac...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Namiki A,Hirai H,Machii K,Ochiai M,Ohshima H,Tohma M,Kuwako K,Yamaguchi T,Toide H,Tohda E

    更新日期:1988-09-01 00:00:00

  • Incidence, characteristics, and outcomes of pediatric out-of-hospital cardiac arrest in nursery schools and kindergartens in Japan.

    abstract:BACKGROUND:A better understanding of the epidemiology of pediatric out-of-hospital cardiac arrest (OHCA) occurring in nursery schools and kindergartens is indispensable to establish an evidence-based strategy for prevention and improved outcomes. This study aimed to describe the incidence, characteristics, and outcomes...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2020.06.003

    authors: Kiyohara K,Kitamura T,Ayusawa M,Nitta M,Iwami T,Nakata K,Matsui S,Sobue T,Kitamura Y,SPIRITS investigators.

    更新日期:2020-12-01 00:00:00

  • Evaluation of objective nutritional indexes as predictors of one-year outcomes after transcatheter aortic valve implantation.

    abstract:BACKGROUND:Objective nutritional indexes have been shown to predict prognoses in some clinical settings. We aimed to investigate the prognostic values of these indexes in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS:We retrospectively analyzed 95 consecutive patients who underwent TAVI a...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2019.02.017

    authors: Okuno T,Koseki K,Nakanishi T,Sato K,Ninomiya K,Tomii D,Tanaka T,Sato Y,Horiuchi Y,Koike H,Yahagi K,Komiyama K,Tanaka J,Aoki J,Yokozuka M,Miura S,Tanabe K

    更新日期:2019-07-01 00:00:00

  • Postconditioning attenuates early ventricular arrhythmias in patients with high-risk ST-segment elevation myocardial infarction.

    abstract:BACKGROUND:It has been demonstrated that postconditioning (postcon), brief episodes of ischemia during reperfusion period, in patients with ST-segment elevation myocardial infarction (STEMI) confers protection against ischemia-reperfusion injury and as a result, postcon might reduce infarct size. However, whether postc...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jjcc.2015.02.010

    authors: Araszkiewicz A,Grygier M,Pyda M,Rajewska J,Lesiak M,Grajek S

    更新日期:2015-06-01 00:00:00

  • Serum cystatin C levels are associated with coronary artery calcification in women without chronic kidney disease.

    abstract:BACKGROUND:Chronic renal disease (CKD) is a determinant of coronary artery calcification (CAC), which is a predictor of cardiovascular events. However, in a population without CKD, the association between CAC and renal function is unclear. CAC is affected by sex. This study aimed to determine whether serum cystatin C, ...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jjcc.2017.05.001

    authors: Sugiyama H,Miyoshi T,Osawa K,Miki T,Koide Y,Nakamura K,Morita H,Ito H

    更新日期:2017-12-01 00:00:00

  • Real clinical management of patients with isolated superior mesenteric artery dissection in Japan.

    abstract:BACKGROUND:Due to the rarity of this condition, clinical treatment and outcomes in isolated superior mesenteric artery dissection (ISMAD) patients remain unknown. The primary aim of this retrospective multicenter study was to elucidate the treatment strategies and in-hospital outcomes for ISMAD patients by using admini...

    journal_title:Journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jjcc.2017.08.006

    authors: Mizuno A,Iguchi H,Sawada Y,Nomura H,Komiyama N,Watanabe S,Yoshikawa A

    更新日期:2018-02-01 00:00:00

  • [Noninvasive evaluation of left ventricular function using new systolic time intervals obtained from continuous-wave Doppler echocardiography].

    abstract::Left ventricular function was evaluated using parameters derived from the flow velocity waveforms at the ascending aorta as obtained at the suprasternal notch by continuous-wave Doppler echocardiography in 39 patients; 12 with chest pain but without coronary stenosis, eight with angina pectoris; and 19 with myocardial...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Ohte N,Nakano S,Hashimoto T,Narita H,Fujinami T

    更新日期:1990-01-01 00:00:00

  • Risk factors and the effects of xamoterol in idiopathic dilated cardiomyopathy.

    abstract::A long-term follow-up study was performed for 110 patients with idiopathic dilated cardiomyopathy (DCM) for 34 +/- 12 months (range 3-122 months). Thirteen patients died of heart failure, 15 of sudden death and one of non-cardiac death. The 3- and 5-year survival rates were 78 and 62%, respectively. The important fact...

    journal_title:Journal of cardiology

    pub_type: 杂志文章

    doi:

    authors: Watanabe K,Hirokawa Y,Suzuki K,Masani F,Otsuka H,Izumi T,Shibata A

    更新日期:1992-01-01 00:00:00