Abstract:
BACKGROUND:There are two types of circulating proprotein convertase subtilisin/kexin type 9 (PCSK9), mature and furin-cleaved. Most types of lipoprotein(a) [Lp(a)], an independent risk factor of cardiovascular events, bind to mature PCSK9. OBJECTIVE:This study examined the effects of monoclonal anti-PCSK9 antibody on plasma PCSK9 and Lp(a) levels in acute myocardial infarction (MI). METHODS:Acute MI patients (n=36) were randomly divided into evolocumab (140mg; n=17) and non-evolocumab (n=19) groups. Changes in plasma PCSK9 and Lp(a) levels were monitored before and 1, 3, 5, 10, and 20 days after evolocumab administration. RESULTS:In the non-evolocumab group, plasma levels of mature PCSK9, furin-cleaved PCSK9, and Lp(a) (236.4±57.3ng/mL, 22.4±5.8ng/mL, and 19.2.±16.5mg/dL, respectively) significantly increased by day 3 (408.8±77.1ng/mL, p<0.001; 47.2±15.7ng/mL, p<0.001; and 39.7±21.3mg/dL, p<0.005, respectively) and returned to the baseline by day 10 or 20. In the evolocumab group, mature PCSK9 significantly increased by >1000ng/mL with a simultaneous decline of furin-cleaved PCSK9 below the measurement sensitivity level after day 3. The incremental area under the curve for plasma Lp(a) levels was significantly smaller in the evolocumab group compared with the non-evolocumab group (p=0.038). CONCLUSION:Mature and furin-cleaved PCSK9 are transiently upregulated after MI onset. Evolocumab significantly increases mature PCSK9 and decreases furin-cleaved PCSK9 and might inhibit transient increase of plasma Lp(a) in acute MI.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Nakamura A,Kanazawa M,Kagaya Y,Kondo M,Sato K,Endo H,Nozaki Edoi
10.1016/j.jjcc.2020.04.006subject
Has Abstractpub_date
2020-10-01 00:00:00pages
395-401issue
4eissn
0914-5087issn
1876-4738pii
S0914-5087(20)30156-8journal_volume
76pub_type
杂志文章abstract::A 32-year-old woman presented with a rare case of tricuspid valve endocarditis causing inflammatory reopening of the spontaneously closed ventricular septal defect (VSD), associated with aortic valve malformation. She was admitted to our hospital because of fever lasting 4 weeks. Severe aortic regurgitation was reveal...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Most studies pay attention to the relationship between insulin resistance and coronary artery disease (CAD) in patients with abnormal glucose tolerance. But few studies have focused on the role of insulin secretion. The aim of this study was to investigate the association between insulin sensitivity, insulin...
journal_title:Journal of cardiology
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abstract:BACKGROUND:We previously reported a cross-sectional analysis regarding the relationship between smoking and atrial fibrillation (AF) in a single hospital-based cohort with Japanese patients, but the effect of cessation of smoking and/or total tobacco consumption were unclear. METHODS AND RESULTS:We used data from the ...
journal_title:Journal of cardiology
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doi:10.1016/j.jjcc.2014.09.010
更新日期:2015-07-01 00:00:00
abstract::Atrial fibrillation (AF) causes severe cardiac dysrhythmia among patients with cardiovascular diseases. AF increases the risk of stroke and heart failure and is a growing public health concern. AF is also associated with various disease conditions such as hypertension, coronary artery disease, aging, and diabetes mell...
journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2019.05.018
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.01.006
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Syndecan-4 is a transmembrane heparan sulfate-carrying glycoprotein that mediates signal transduction pathways activated by growth factors and cell surface receptors, thereby modulating tissue regeneration, angiogenesis, and focal adhesion. The aim of the present study was to determine the clinical use of se...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2011.01.012
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Coronary collateral circulation (CCC) has been demonstrated to be impaired in patients with type 2 diabetes mellitus which is characterized by insulin resistance. In this study, our purpose was to find out a possible relationship between CCC and non-alcoholic fatty liver disease (NAFLD), which is...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.05.003
更新日期:2012-09-01 00:00:00
abstract::To assess left ventricular (LV) diastolic function in patients with LV dysfunction, LV pressures (manometer tip) and biplane angiograms were analyzed for 27 patients with LV systolic dysfunction (EF < or = 0.45) (dilated cardiomyopathy or coronary artery disease) and 18 normal controls. LV volumes were obtained from f...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:Few intravenous myocardial contrast echocardiography trials have evaluated myocardial perfusion in small animals. The feasibility of using intravenous myocardial contrast echocardiography to assess the ischemic area in rats was investigated. METHODS:Fourteen open chest Wister male rats were examined. Intrav...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::A 66-year-old woman had suffered from repeated heart failure beginning 6 years after mitral valve replacement. Left ventricular pseudoaneurysm was discovered 9 years after the replacement, while no evidence including histology was obtained for the cause of the pseudoaneurysm except the mitral valve replacement. The pr...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Current guidelines recommend early termination of triple therapy and the use of direct oral anticoagulants (DOAC) for non-valvular atrial fibrillation (NVAF) patients who undergo percutaneous coronary intervention (PCI), due to safety concerns. However, to date, real-world medication usage and safety outcome...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2020.08.008
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:An admission to the intensive care unit (ICU) after developing acute myocardial infarction (AMI) has been the standard of care and is recommended by professional societies. However, evidence that justifies its use, such as a reduction in mortality, has never been shown despite the associated financial burden...
journal_title:Journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jjcc.2019.01.007
更新日期:2019-08-01 00:00:00
abstract::A 21-year-old man underwent aortic valvuloplasty for aortic regurgitation due to bicuspid aortic valve. After the initial procedure for valvuloplasty of the anterior cusp, transesophageal color Doppler flow imaging revealed a significant regurgitant jet directed posteriorly as observed preoperatively. After an additio...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Spontaneous coronary artery dissection (SCAD) is a rare condition that most often presents as acute coronary syndrome or sudden cardiac death. Here we present the case of a young man of 25 years, who had remained asymptomatic in spite of SCAD. This case highlights the fact that spontaneous dissections can occur at a y...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2009.03.007
更新日期:2009-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2020.11.010
更新日期:2020-11-30 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2015.06.015
更新日期:2016-05-01 00:00:00
abstract::The cardiovascular system may be involved as a target organ of multifocal fibrosclerosis, which may manifest as idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, inflammatory periarteritis, and inflammatory pericarditis. These pathological conditions can sometimes occur concomitantly. Idiopathic retro...
journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2011.10.005
更新日期:2012-03-01 00:00:00
abstract::The clinical significance of the flow velocity of the superior vena cava (SVC) in old myocardial infarction (OMI) with severe left ventricular dysfunction were evaluated using pulsed Doppler echocardiography. The subjects consisted of 10 patients with OMI (averaged left ventricular ejection fraction: 0.37 +/- 0.11) an...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVES:To investigate the useful parameters of transthoracic echocardiography (TTE) for the diagnosis of stroke subtypes in patients with acute cerebral infarction. METHODS:One hundred and one acute ischemic stroke patients met all of the following criteria; > or = 50 years of age, normal sinus rhythm on admission...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::To elucidate the circumstances involving sudden death, deaths among 20,685 male employees of "K" company during a six-year period from April 1981 to March 1987 were reviewed. The subject age ranged from 19 through 59 years, and averaged 38.6 years. Information concerning each death was obtained from the death reports ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Based on the importance of left ventricular (LV) diastolic function in stratification of the cardiac prognosis in patients with systolic heart failure (SHF), we attempted to identify the prognostic impact of Doppler echocardiographic examinations and plasma B-type natriuretic peptide (BNP) concentration. ME...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.07.008
更新日期:2008-12-01 00:00:00
abstract::Eleven directional coronary atherectomy procedures were performed in seven patients with angina pectoris and four patients with myocardial infarction, 10 men and 1 woman aged 41 to 69 years (mean 57 +/- 7 years). The onset of angina pectoris or myocardial infarction had occurred 2 months to 17 years previously. The pr...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::We assessed the usefulness of myoglobin measured by latex agglutination methods as a parameter for successful reperfusion of the infarct-related artery. Plasma myoglobin levels were measured for 25 patients with acute myocardial infarction in whom thrombolysis and/or percutaneous transluminal coronary angioplasty (PTC...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The influence of complete revascularization on long-term outcome of patients with multivessel coronary artery disease undergoing percutaneous transluminal coronary angioplasty (PTCA) was determined by analysis of 10-year survival in 167 consecutive patients treated at Juntendo University Hospital during 1984-1993. For...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2019.12.006
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:Nonvalvular atrial fibrillation is a known risk factor for thromboembolism. This study investigated the use of coagulation markers to predict thromboembolism in nonvalvular atrial fibrillation patients. METHODS:One hundred thirty nonvalvular atrial fibrillation patients (104 males, 26 females, mean age 63.7...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-01-01 00:00:00