Abstract:
BACKGROUND:Atrioventricular (AV) block is one of the main clinical manifestations in patients with cardiac sarcoidosis (CS). Although steroid therapy is considered to be effective for AV block, the efficacy has not been demonstrated in detail. METHODS AND RESULTS:Fifteen CS patients presenting with advanced or complete AV block were retrospectively investigated. All patients were treated with 30mg/day of prednisone after device implantation, which was tapered to a maintenance dosage of 5-10mg/day. During a mean follow-up of 7.1 years, AV block resolved to normal conduction or first-degree AV block in 7 patients (recovery group). The improvement was driven within the first week of steroid therapy in 4 patients, while 3 patients showed late recovery of AV conduction. The remaining 8 patients were classified as the non-recovery group. The recovery group showed a higher left ventricular ejection fraction (69.4±8.9% versus 44.1±19.3%, p=0.029) and higher prevalence of advanced AV block (87.5% versus 28.6%, p=0.040) compared with those of the non-recovery group. In patients with the recovery group, there was no late recurrence of AV block during the follow-up period. CONCLUSIONS:Early initiation of steroid therapy may be effective for AV block, and steroid therapy before device implantation is a possible therapeutic strategy for some selected patients.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Yodogawa K,Seino Y,Shiomura R,Takahashi K,Tsuboi I,Uetake S,Hayashi H,Horie T,Iwasaki YK,Hayashi M,Miyauchi Y,Shimizu Wdoi
10.1016/j.jjcc.2013.07.007subject
Has Abstractpub_date
2013-11-01 00:00:00pages
320-5issue
5eissn
0914-5087issn
1876-4738pii
S0914-5087(13)00232-3journal_volume
62pub_type
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pub_type: 杂志文章,meta分析
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doi:10.1016/j.jjcc.2015.01.011
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abstract::Although the mechanism for the occurrence of acute myocardial infarction (MI) has been investigated by many pathological and clinical studies, it has not been adequately clarified yet. Although the disruption of vulnerable plaque is a well-known cause of acute MI, there are many silent plaque disruptions detected in t...
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2008.02.001
更新日期:2008-04-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.05.002
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doi:10.1016/j.jjcc.2008.11.013
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::To assess left ventricular (LV) diastolic function in patients with LV dysfunction, LV pressures (manometer tip) and biplane angiograms were analyzed for 27 patients with LV systolic dysfunction (EF < or = 0.45) (dilated cardiomyopathy or coronary artery disease) and 18 normal controls. LV volumes were obtained from f...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.05.001
更新日期:2013-11-01 00:00:00
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doi:
更新日期:2003-10-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-12-01 00:00:00
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doi:
更新日期:1988-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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更新日期:2001-04-01 00:00:00
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doi:
更新日期:2001-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00