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Transient increase in blood thrombogenicity may be a critical mechanism for the occurrence of acute myocardial infarction.

Abstract：

:Although the mechanism for the occurrence of acute myocardial infarction (MI) has been investigated by many pathological and clinical studies, it has not been adequately clarified yet. Although the disruption of vulnerable plaque is a well-known cause of acute MI, there are many silent plaque disruptions detected in the coronary artery by intravascular imaging studies. Therefore, many vulnerable plaques may disrupt and heal without causing acute MI. Some additional mechanisms other than the disruption of vulnerable plaque would be essential for the onset of acute MI. On the other hand, blood thrombogenicity would change dynamically due to circadian rhythms and many other factors. The combination of plaque and blood thrombogenicity would play an important and determinant role for the onset of acute MI.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Ueda Y,Kosugi S,Abe H,Ozaki T,Mishima T,Date M,Uematsu M,Koretsune Y

doi

10.1016/j.jjcc.2020.08.007

subject

Has Abstract

pub_date

2020-09-10 00:00:00

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(20)30292-6

pub_type

杂志文章,评审

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