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Heart failure: what does ejection fraction have to do with it?

Abstract：

:Heart failure (HF) occurs across the entire range of left ventricular (LV) ejection fractions (EF), not just reduced EF. Nearly half or more patients presenting with HF have a preserved EF>0.50 (HFpEF). Diastolic dysfunction is apparent in all patients with HF, regardless of EF. A preserved EF indicates that the end-diastolic volume is appropriate for the stroke volume, and a reduced EF indicates that the end-diastolic volume is enlarged relative to stroke volume (i.e. the LV is dilated). Most therapies proven to be effective in HF with a reduced EF (ACE-inhibitors, angiotensin receptor blockers, beta-blockers, and cardiac resynchronization) reverse LV dilation. These therapies have not been proven to be effective in HFpEF. Increasing c-GMP may be a treatment target in HFpEF, and potential ways of increasing c-GMP are being studied. Finally, comorbidities are important in HFpEF and are additional targets for therapy.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Iwano H,Little WC

doi

10.1016/j.jjcc.2013.02.017

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1-3

issue

1

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(13)00111-1

journal_volume

62

pub_type

杂志文章,评审

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