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Physical activity and progression of carotid intima-media thickness in patients with coronary heart disease.

Abstract：

OBJECTIVE:We conducted the present study to determine the level of physical activity required to retard the progression of carotid intima-media thickness (IMT) in patients with coronary heart disease (CHD). PATIENTS AND MAIN OUTCOME MEASUREMENTS:The daily walking distance (km/day) of 40 patients with CHD (male/female ratio: 37/3, mean age: 61.2 years, mean interval time after a coronary event 16.2 months) was examined. Carotid IMT examinations (B-mode ultrasonography) were performed at the baseline and after 6 months. RESULTS:Among the patients, the average walking distance was 4.00km/day. Walking distance was inversely associated with IMT progression (r=-0.51, p<0.01). Multivariate logistic regression analysis revealed that walking distance (p=0.024) is a predictor for IMT progression independent of classical cardiovascular risk factors. Receiver operating characteristic analysis showed that the walking distance of 4.25km was strongly predictive of IMT preservation (sensitivity 64.0%, specificity 73.3%) in CHD patients. CONCLUSIONS:Our data suggested that an increase in the daily walking distance could retard the progression of carotid IMT in patients with CHD. Cardiology medical staff should encourage their patients to expend an average of 4-5km in daily walking distance for the secondary prevention of cardiovascular disease.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Sato S,Makita S,Uchida R,Ishihara S,Majima M

doi

10.1016/j.jjcc.2008.02.005

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

157-62

issue

3

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(08)00090-7

journal_volume

51

pub_type

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