Design of therapeutic vaccines as a novel antibody therapy for cardiovascular diseases.

abstract：OBJECTIVES:Although physicians frequently perform palpation of the apex beat to evaluate left ventricular (LV) size and hypertrophy, the clinical significance of apex beat palpation is still unclear. The introduction of multislice computed tomography (MSCT) has enabled assessment not only of coronary stenoses but also ...

journal_title：Journal of cardiology

authors： Ehara S,Okuyama T,Shirai N,Oe H,Matsumura Y,Sugioka K,Itoh T,Otani K,Hozumi T,Yoshiyama M,Yoshikawa J

更新日期：2010-03-01 00:00:00

abstract：:To clarify the effects of mitral obstruction on left ventricular (LV) diastolic blood filling, 15 patients with tight mitral stenosis (each mitral valve area was less than 1.5 cm2) were studied. Each selected patient underwent successful percutaneous transluminal mitral commissurotomy (PTMC), which resulted in a 1.5 f...

journal_title：Journal of cardiology

authors： Goto S,Abe S,Akaishi M,Yoshikawa T,Matsubara T,Ogawa S,Handa S

更新日期：1992-01-01 00:00:00

abstract：:A 76-year-old woman was admitted to our hospital with cardiac tamponade. Chest computed tomography revealed a large tumor adjacent to the pulmonary artery, the center of which was demonstrated as a high density area without contrast medium. Coronary angiography revealed a large aneurysm consisting of coronary artery f...

journal_title：Journal of cardiology

authors： Iwasawa Y,Kitamura Y,Higuma K,Ono F,Imoto K,Kimura K

更新日期：2007-07-01 00:00:00

abstract：:In nine patients with cardiac dysfunction (ejection fraction less than or equal to 50%), we evaluated the effects of dobutamine (5 micrograms/kg/min) on ventriculo-arterial coupling by monitoring direct arterial pressures and simultaneously-recorded M-mode echocardiograms guided with two-dimensional images. Left ventr...

journal_title：Journal of cardiology

authors： Ishizaka S,Asanoi H,Kameyama T,Sasayama S

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Hemodialysis (HD) patients are at high risk for adverse clinical outcomes after drug-eluting stent (DES) implantation. However, the impact of residual platelet reactivity under dual anti-platelet therapy in this subset of patients remains unclear. METHODS:We enrolled 142 stable angina patients (194 lesions)...

journal_title：Journal of cardiology

authors： Konishi A,Shinke T,Otake H,Takaya T,Osue T,Kinutani H,Kuroda M,Takahashi H,Terashita D,Hirata K

更新日期：2016-06-01 00:00:00

abstract：:There have been several case reports, a total of 22 up to the present, of toxoplasma pericarditis. Out of them, in only a few cases the diagnosis was properly made with a proof of the microscopic presence of Toxoplasma gondii. This is the first report of toxoplasma pericarditis in which the presence of Toxoplasma gond...

journal_title：Journal of cardiology

authors： Sano J,Saitoh H,Kobayashi Y,Ikeda M,Kodani E,Takayama M,Kishida H,Takano T,Yano A

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:While physical rehabilitation has been shown to be beneficial and safe for patients suffering from heart failure, data on rehabilitation for hypertrophic cardiomyopathy (HCM) patients are limited. METHODS:Forty-five HCM patients participated in an exercise rehabilitation program. Exercise capacity was measu...

journal_title：Journal of cardiology

authors： Wasserstrum Y,Barbarova I,Lotan D,Kuperstein R,Shechter M,Freimark D,Segal G,Klempfner R,Arad M

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Left atrial (LA) enlargement has been documented to occur in hypertension (HT), and has been an index for evaluating the diastolic function of the left ventricle. Enlargement of the LA is one of the vital factors that induce heart failure and atrial fibrillation (AF) in patients with HT. METHODS AND SUBJECT...

journal_title：Journal of cardiology

authors： Chen Y,Sato H,Watanabe N,Adachi T,Kodani N,Sato M,Takahashi N,Kitamura J,Sato H,Yamaguchi K,Yoshitomi H,Tanabe K

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:Nifekalant is a class III antiarrhythmic drug, which prolongs the refractory period of the atrial and ventricular myocardium, without negative inotropic action. Intravenous nifekalant was administered in four patients with atrial tachyarrhythmia and severe heart failure to terminate or prevent atrial tachyar...

journal_title：Journal of cardiology

authors： Shiga T,Matsuda N,Fuda Y,Haruta S,Hagiwara N,Kasanuki H

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Cholinergic nerve plays an important role in the induction and maintenance of atrial fibrillation (AF). Cholinergic innervation at supraventricular tissues is considered to be the histological basis and intervention-associated target site for the arrhythmia; however, the distribution of cholinergic nerve in sup...

journal_title：Journal of cardiology

authors： Li Z,Zhao QY,Huang H,Yang B,Jiang H,Huang CX

更新日期：2013-03-01 00:00:00

abstract：:Elevated levels of lipoprotein(a) [Lp(a)] have been associated with an increased risk of ischemic heart disease (IHD), and higher levels of Lp(a) are associated with lesions of significantly greater severity. We have examined Lp(a), total cholesterol (TC) and high density lipoprotein-cholesterol (HDL-C) levels in pati...

journal_title：Journal of cardiology

authors： Nakamura Y,Yokoi Y,Hamaguchi H,Toyonaga T,Kondo T,Takami S,Kubo M,Matsuzawa Y

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Left ventricular diastolic dysfunction (LVDD) plays an important role in heart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot with possible paracrine or mechanical effects on the coronary cir...

journal_title：Journal of cardiology

authors： Konishi M,Sugiyama S,Sugamura K,Nozaki T,Matsubara J,Akiyama E,Utsunomiya D,Matsuzawa Y,Yamashita Y,Kimura K,Umemura S,Ogawa H

更新日期：2012-05-01 00:00:00

abstract：:Coronary plaque has a distinct spatial distribution with the peak incidence on the outer wall around the bifurcation of the left main coronary artery. Intravascular ultrasound scanning was used to evaluate the distribution of the plaque in the proximal site of the left anterior descending coronary artery in 16 patient...

journal_title：Journal of cardiology

authors： Watanabe H,Yoshikawa J,Yoshida K,Akasaka T,Hozumi T,Takagi T,Honda Y,Okura H,Yamamuro A

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Anticoagulant therapy is used for preventing cerebral infarction in patients with non-valvular atrial fibrillation (NVAF). However, in clinical practice, many patients with NVAF are not prescribed oral anticoagulants (OACs). In this study, we retrospectively investigated the prescription status of OACs at th...

journal_title：Journal of cardiology

authors： Deguchi I,Osada T,Takao M

更新日期：2020-05-01 00:00:00

abstract：:A 66-year-old man was admitted with distal edema of his right leg. He had undergone radical prostatectomy and pelvic lymphadenectomy for prostatic cancer 23 days previously. Abdominal computed tomography (CT) showed a lymphocyst (4.5 x 3.0 cm) along the right pelvic wall compressing the right external iliac vein. CT w...

journal_title：Journal of cardiology

authors： Hirabayashi N,Sakurai S,Komiyama I,Yokoyama J,Kontani K,Yoneyama T,Hirase Y,Koshihara H,Itoh A,Ikeda U

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Aortic valve calcification (AVC) reflects the state of aortic valve sclerosis (AVS), which is a precursor to aortic valve stenosis (AS). Therefore, we investigated the presence of AVC in patients who underwent coronary computed tomography angiography (CTA), which is an effective tool for evaluating early-stag...

journal_title：Journal of cardiology

authors： Norimatsu K,Miura S,Suematsu Y,Shiga Y,Miyase Y,Nakamura A,Zhang B,Saku K

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:The effectiveness of percutaneous transluminal coronary intervention (PCI) was evaluated for chronic total occlusion (CTO) assessed as non-viable by myocardial scintigraphy. METHODS:In the period from January 2003 to October 2006, 17 patients who had successful reopening of the artery through revascularizat...

journal_title：Journal of cardiology

authors： Nii H,Wagatsuma K,Kabuki T,Uchida Y,Amano H,Toda M,Yamashina S,Yamazaki J

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:Nonvalvular atrial fibrillation is a known risk factor for thromboembolism. This study investigated the use of coagulation markers to predict thromboembolism in nonvalvular atrial fibrillation patients. METHODS:One hundred thirty nonvalvular atrial fibrillation patients (104 males, 26 females, mean age 63.7...

journal_title：Journal of cardiology

authors： Enta K,Iwade K,Aosaki M,Uchida T,Kasanuki H

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Although the Klotho gene is recognized as an aging-suppressor gene, the clinical significance of its soluble product, soluble Klotho, in coronary artery disease (CAD) has not been completely determined. The relationship between soluble Klotho and coronary artery calcification (CAC) was investigated in patien...

journal_title：Journal of cardiology

authors： Koga S,Ikeda S,Akashi R,Yonekura T,Kawano H,Maemura K

更新日期：2020-12-07 00:00:00

abstract：:No heart transplants have been performed in Japan due to various obstacles since the only operation performed in 1968. Since 1981, a number of patients requiring heart transplants have been accepted by foreign transplantation centers in England, the U.S.A., and Germany. This report describes an investigation of the po...

journal_title：Journal of cardiology

authors： Hachida M,Koyanagi H,Matsuda H,Sono J,Akasaka T,Tanaka K,Nunoda S,Satomi G,Koike K,Miyamoto N,Omoto R

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is an evolving paradigm for the risk assessment of cardiovascular diseases. We hypothesized that an advanced stage of CKD may predict the presence of peripheral arterial disease (PAD). METHODS:Screening for PAD by an ankle-brachial pressure index (ABI) ≤0.9 was conducted in a co...

journal_title：Journal of cardiology

authors： Yamasaki S,Izawa A,Koshikawa M,Saigusa T,Ebisawa S,Miura T,Shiba Y,Tomita T,Miyashita Y,Koyama J,Ikeda U

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Myocyte injury might be involved in the progression of essential hypertension (EHT) toward heart failure (HF). However, in the absence of high-sensitivity (hs) assay, cardiac troponin T (TnT) in EHT has not been measurable. METHODS AND RESULTS:We studied 236 consecutive ambulatory patients (mean age=65.5 ye...

journal_title：Journal of cardiology

authors： Sato Y,Yamamoto E,Sawa T,Toda K,Hara T,Iwasaki T,Fujiwara H,Takatsu Y

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:The standard deviation of the washout rate in dipyridamole stress thallium-201 myocardial single photon emission computed tomography (SPECT) was correlated with the severity of coronary artery lesions and the viability of ischemic myocardium to provide a new quantitative parameter for judging indications for...

journal_title：Journal of cardiology

authors： Arao M,Setsuta K,Seino Y,Takano T

更新日期：2000-11-01 00:00:00

abstract：:A one-hour protocol for stress myocardial scintigraphy using technetium-99m-tetrofosmin (Tc-tetrofosmin) was compared with coronary arteriography for the detection of coronary artery stenosis in 90 consecutive patients without prior myocardial infarction, revascularization procedure or vasospastic angina. Tc-tetrofosm...

journal_title：Journal of cardiology

authors： Matsuda J,Miyamoto N,Onitsuka H,Ikushima I,Unoki T,Takenaga M,Koiwaya Y,Eto T

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVES:This study was designed to determine the prognostic importance of left ventricular (LV) myocardial stiffness, a hemodynamic index which is closely related to B-type natriuretic peptide (BNP) concentration in patients with congestive heart failure (CHF). BACKGROUND:While elevated BNP, an abnormality of cardi...

journal_title：Journal of cardiology

authors： Watanabe S,Shite J,Takaoka H,Shinke T,Tanino Y,Otake H,Matsumoto D,Ogasawara D,Sawada T,Hirata K,Yokoyama M

更新日期：2011-11-01 00:00:00

abstract：:A 67-year-old man with exertional angina presented with a large pseudoaneurysm of the right coronary artery at eight months after balloon angioplasty. Intravascular ultrasound revealed a large saccular pseudoaneurysm of 10.9 x 5.7 mm diameter at the proximal segment of the right coronary artery. Complete closure of th...

journal_title：Journal of cardiology

authors： Yasukawa T,Ozaki Y,Kakihana M,Shinjo H,Waseda K,Kuroda Y,Asai K,Wakita Y,Kono T,Takashima H,Ito T

更新日期：2003-12-01 00:00:00

abstract：:The patient was a 37-year-old female who had undergone a repair for tetralogy of Fallot (TOF) at the age of 4 years. Postoperative pulmonary stenosis remained, but she continued to be managed medically. Approximately 3 years ago, at the age of 34, she exhibited a worsening of fatigue and dyspnea during exertion (New Y...

journal_title：Journal of cardiology

authors： Fujii A,Funada J,Morioka N,Hashida H,Iwata T,Higaki T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Catheter ablation has become a standard treatment strategy for drug-resistant symptomatic non-valvular atrial fibrillation (NVAF). Periprocedural administration of uninterrupted warfarin could reduce the risk of thromboembolic complications. However, only a few retrospective studies have reported on the effi...

journal_title：Journal of cardiology

authors： Goya M,Nogami A,Hirao K,Aonuma K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Although eastern Asian countries are exposed to high levels of air pollution, the impact of long-term exposures to fine particulate matter (PM2.5) air pollution on all-cause and cardiovascular mortality is not well identified. We assessed the relationship between long-term PM2.5 exposure and all-cause/cardio...

journal_title：Journal of cardiology

authors： Kim IS,Yang PS,Lee J,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Joung B

更新日期：2020-05-01 00:00:00

abstract：:The cardiovascular system may be involved as a target organ of multifocal fibrosclerosis, which may manifest as idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, inflammatory periarteritis, and inflammatory pericarditis. These pathological conditions can sometimes occur concomitantly. Idiopathic retro...

journal_title：Journal of cardiology

authors： Ishizaka N,Sakamoto A,Imai Y,Terasaki F,Nagai R

更新日期：2012-03-01 00:00:00