Abstract:
BACKGROUND:Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a sensitive marker both for the severity of coronary artery disease and vulnerable plaques. Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques. METHODS AND RESULTS:We measured PTX3 concentrations in the peripheral and coronary sinus plasma of 40 patients with angina pectoris (AP) and 20 control subjects. Next, in 28 patients with AP, we determined the correlation between levels of inflammatory molecules and the computed tomography (CT) density of plaques as a quantitative index of plaque vulnerability. There was no significant difference in peripheral plasma PTX3 concentrations between patients with AP and control subjects, while coronary sinus plasma PTX3 concentrations were significantly higher in AP patients than control subjects. The concentrations of PTX3 in coronary sinus and peripheral plasma correlated with Gensini scores as an index of severity of coronary atherosclerosis. Interestingly, there was a significantly negative correlation between plasma PTX3 concentrations and CT density (r=-0.67, p<0.01). On the other hand, CT density did not correlate with the peripheral plasma concentrations of monocyte chemoattractant protein-1 (MCP-1) or high-sensitivity CRP (hsCRP). Furthermore, telmisartan treatment for 6 months decreased plasma concentrations of PTX3 but not those of MCP-1 or hsCRP in 12 patients with essential hypertension. Multivariate regression analysis revealed that changes in PTX3 levels were independent of blood pressure changes. CONCLUSIONS:PTX3 is likely more specific than hsCRP as an indicator of coronary plaque vulnerability that could lead to plaque rupture.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Soeki T,Niki T,Kusunose K,Bando S,Hirata Y,Tomita N,Yamaguchi K,Koshiba K,Yagi S,Taketani Y,Iwase T,Yamada H,Wakatsuki T,Akaike M,Sata Mdoi
10.1016/j.jjcc.2011.04.005subject
Has Abstractpub_date
2011-09-01 00:00:00pages
151-7issue
2eissn
0914-5087issn
1876-4738pii
S0914-5087(11)00088-8journal_volume
58pub_type
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更新日期:1988-09-01 00:00:00
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journal_title:Journal of cardiology
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更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:The effectiveness of percutaneous transluminal coronary intervention (PCI) was evaluated for chronic total occlusion (CTO) assessed as non-viable by myocardial scintigraphy. METHODS:In the period from January 2003 to October 2006, 17 patients who had successful reopening of the artery through revascularizat...
journal_title:Journal of cardiology
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更新日期:2007-12-01 00:00:00
abstract::The precipitating factors of repetitive exacerbation were investigated in 110 consecutive patients with chronic left heart failure admitted due to acute exacerbation more than twice to the medical emergency ward of National Cardiovascular Center from January, 1992 to December, 1996. The controls were 189 consecutive p...
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更新日期:1998-04-01 00:00:00
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abstract::The clinical benefit of cholesterol-lowering treatment is unknown in the Japanese elderly in whom the prevalence of morbidity and mortality related to coronary artery disease are known to be low. To evaluate the efficacy of cholesterol-lowering treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase i...
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pub_type: 临床试验,杂志文章
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更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Puerarin is the most abundant isoflavonoid in kudzu root. It has been used to treat angina pectoris and myocardial infarction clinically. However, little is known about the effect of puerarin on cardiac hypertrophy. METHODS:Aortic banding (AB) was performed to induce cardiac hypertrophy in mice. Puerarin pr...
journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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更新日期:2000-07-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2011.05.002
更新日期:2011-09-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.09.001
更新日期:2009-06-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Pentraxin 3 (PTX3) is increased in circulating blood during the acute stage of acute coronary syndrome (ACS). Therefore, we compared diagnostic values of PTX3 for ACS with those of biomarkers for myocardial damage, such as troponin T (TnT) and heart-type fatty acid binding protein (H-FABP). METHODS AND RESU...
journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2017.10.008
更新日期:2018-03-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2012.08.009
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Patients receiving chronic hemodialysis develop complicated coronary lesions with tortuosity and calcification, which make stent delivery or expansion difficult. Restenosis rates are also higher than in patients without hemodialysis. Furthermore, there is a risk of polymer rubbing from the surface of a sirol...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::Diabetes mellitus may be an independent risk factor for disturbance of cardiac function, but the detailed mechanism remains unclear. In the present study, histological examinations were carried out on 25 hearts from diabetes model rats as well as myocardial biopsy materials from patients with diabetes (n = 25). The me...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:The short-term and long-term predictors of outcome after coronary angioplasty in the unprotected left main coronary artery were investigated. METHODS:The procedure was performed in 122 consecutive patients for de novo lesions without myocardial infarction in our hospital between April 1986 and October 1998,...
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pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2010.10.007
更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:This study investigated the safety and efficacy of sirolimus-eluting stents (SESs) on early and late outcomes in patients with acute myocardial infarction. METHODS:A series of 100 consecutive patients (September 2004 to November 2005)with acute myocardial infarction undergoing primary stenting using SES pte...
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pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2016.04.012
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The outcome of percutaneous coronary intervention (PCI) has been reported to be poor in hemodialysis (HD) patients even in the drug-eluting stent era. We have reported relatively poor outcomes after sirolimus-eluting stent implantation in the OUCH study. METHODS:The OUCH-TL study is a prospective, non-rando...
journal_title:Journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.08.012
更新日期:2009-02-01 00:00:00