Abstract:
BACKGROUND AND PURPOSE:CYP2C19*2 loss-of-function allele in Caucasians may be associated with wide interindividual variability in platelet response to clopidogrel, and the incidence of gene mutation varies with racial differences, especially between Asians and Caucasians. The aim was to examine the impact of CYP2C19 genotype on the residual platelet reactivity in Japanese patients with coronary heart disease (CHD) during antiplatelet therapy. METHODS AND RESULTS:We measured the CYP2C19 genotype and platelet aggregation in 201 patients with stable CHD. Moreover, we examined the relation of CYP2C19 polymorphism to cardiovascular events in 98 patients treated with stent implantation. The distribution of CYP2C19 genotype was 37%, 33%, 11%, 11%, 7%, and 1% in CYP2C19*1/*1, *1/*2, *1/*3, *2/*2, *2/*3, and *3/*3, respectively. Residual platelet reactivity was lower in patients during dual antiplatelet therapy (DAT) than in those with aspirin (3975 ± 1569 aggregation units minute (AU min) vs 5850 ± 938 AU min, p<0.05). In the DAT group, the platelet reactivity decreased significantly in the wild-type homozygotes (CYP2C19*1/*1), subsequently in the *2, or *3 heterozygotes (*1/*2, *1/*3), and was not well inhibited in the *2, and/or *3 homozygotes (*2/*2, *2/*3, *3/*3; 3194 ± 1570 AU min, 4148 ± 1400 AU min, and 5088 ± 1080 AU min, respectively). However, when the duration of DAT was used to divide subjects into 2 groups, <7 days, and >7 days, patients carrying the variant allele showed significantly decreased platelet reactivities at >7 days compared with those at <7 days. Moreover, the incidence of cardiovascular events was higher in patients carrying at least one variant allele than in wild-type homozygotes. CONCLUSIONS:CYP2C19 polymorphism may be associated with high residual platelet reactivity and the occurrence of cardiovascular events.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Yamamoto K,Hokimoto S,Chitose T,Morita K,Ono T,Kaikita K,Tsujita K,Abe T,Deguchi M,Miyagawa H,Saruwatari J,Sumida H,Sugiyama S,Nakagawa K,Ogawa Hdoi
10.1016/j.jjcc.2010.10.007subject
Has Abstractpub_date
2011-03-01 00:00:00pages
194-201issue
2eissn
0914-5087issn
1876-4738pii
S0914-5087(10)00219-4journal_volume
57pub_type
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journal_title:Journal of cardiology
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
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doi:
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
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