Abstract:
OBJECTIVES:The relationship between the duration of arrhythmia and the subsequent long-term efficacy of disopyramide in preventing atrial fibrillation was investigated in patients with symptomatic paroxysmal and persistent atrial fibrillation. METHODS:A total of 60 patients (39 men, 21 women, mean age 65 +/- 11 years) were given disopyramide (300 mg/day) after electrical and pharmacological cardioversion based on American Heart Association Task Force on Practice Guidelines. The patients were divided into two types based on the duration of atrial fibrillation: conversion within 48 hr (group A, n = 35) and more than 48 hr (group B, n = 25) after the episode. Mean follow-up period was 47.1 +/- 28.7 months. RESULTS:Patient characteristics showed no statistically significant difference between groups A and B. The actuarial rates of maintenance of sinus rhythm at 1, 3, 6, 12, 18 and 24 months were 88.6%, 77.1%, 57.1%, 48.6%, 42.9% and 37.1%, respectively, in group A, and 72.0%, 44.0%, 28.0%, 16.0%, 12.0% and 8.0%, respectively, in group B. There was a significant difference in the rate at 24 months between groups A and B (p < 0.05). The periods for maintenance of sinus rhythm in groups A and B were 20.9 +/- 3.9 and 6.7 +/- 2.1 months, respectively, with a significant difference between groups A and B (p < 0.01). CONCLUSIONS:The efficacy of disopyramide in preventing the recurrence of atrial fibrillation varies with the duration of the previous episode. These results demonstrate that it is important to convert to normal sinus rhythm earlier to prevent the recurrence of atrial fibrillation in the long term.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Komatsu T,Yomogida K,Nakamura S,Suzuki O,Horiuchi D,Kameda K,Tomita H,Abe N,Owada S,Oikawa K,Okumura Ksubject
Has Abstractpub_date
2003-09-01 00:00:00pages
111-7issue
3eissn
0914-5087issn
1876-4738journal_volume
42pub_type
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journal_title:Journal of cardiology
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
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journal_title:Journal of cardiology
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更新日期:2001-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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doi:
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::Percutaneous transvenous mitral valvuloplasty (PTMV) using the Inoue balloon was performed in 18 patients with symptomatic mitral stenosis. They were seven men and 11 women, ranging in age from 38 to 77 years (mean 59 +/- 10 years). Among them, 13 were categorized as NYHA class II; four as class III; and one as class ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of cardiology
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