Abstract：
:Since the innovation of epoprostenol, a prostacyclin analog, providing treatment for pulmonary arterial hypertension (PAH) in the 1990s, two types of oral drugs, endothelin receptor antagonists (ERAs) and phosphodiesterase V inhibitors, have further improved therapy for PAH. In contrast, it has become clear that the efficacy of monotherapy with these drugs is limited, and the establishment of combination therapies should be considered for PAH. Given that the newest PAH drugs include a receptor tyrosine kinase antagonist (imatinib), a soluble guanylate cyclase stimulator (riociguat), an oral analog of prostacyclin (selexipag), and a tissue targeting ERA (macitentan) determination of appropriate combinations for various etiologies and clinical stages is urgently required. In the next decade, it can be expected that the discovery of efficacious combination therapies, involving old and new drugs, will lead to significant advances in the treatment of PAH.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Yao Adoi
10.1016/j.jjcc.2012.08.009subject
Has Abstractpub_date
2012-11-01 00:00:00pages
344-9issue
5eissn
0914-5087issn
1876-4738pii
S0914-5087(12)00198-0journal_volume
60pub_type
杂志文章,评审abstract：:The effect of verapamil on myocardial ischemia in patients with hypertrophic cardiomyopathy (HCM) was evaluated by exercise myocardial 201Tl SPECT (EX-Tl). EX-Tl was performed before and after 8.1 +/- 6.1 weeks of oral administration of verapamil (240 mg/day) on 20 patients with HCM who showed transient 201Tl perfusio...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVES:To investigate the quality of life (QOL) of Japanese patients with ischemic heart disease. METHODS:The QOL data of 753 patients with chronic and stable ischemic heart disease was assessed using SF-36 Japanese version 1.2 and compared with Japanese national norms. Physical (PCS) and Mental Component Summary ...
journal_title：Journal of cardiology
pub_type： 杂志文章,多中心研究
doi：
更新日期：2005-12-01 00:00:00
abstract：:Inherited primary arrhythmia syndromes (IPAS) may result in ventricular tachycardia or ventricular fibrillation by some genetic disorders, leading to sudden cardiac death. IPAS are also called "channelopathies" since many of these are caused by an abnormality in myocardial ion channels. Congenital long-QT syndrome (LQ...
journal_title：Journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jjcc.2019.01.009
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:A better understanding of the epidemiology of pediatric out-of-hospital cardiac arrest (OHCA) occurring in nursery schools and kindergartens is indispensable to establish an evidence-based strategy for prevention and improved outcomes. This study aimed to describe the incidence, characteristics, and outcomes...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2020.06.003
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. METHODS:Pooled analysis of data from three Korean observational stu...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2015.08.005
更新日期：2016-05-01 00:00:00
abstract：:A one-hour protocol for stress myocardial scintigraphy using technetium-99m-tetrofosmin (Tc-tetrofosmin) was compared with coronary arteriography for the detection of coronary artery stenosis in 90 consecutive patients without prior myocardial infarction, revascularization procedure or vasospastic angina. Tc-tetrofosm...
journal_title：Journal of cardiology
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:The treadmill exercise test (TET) is evaluated by exercise-induced ST-segment depression (delta ST). However, the depression sometimes only appears during the post-exercise period. Depression appearing only during the post-exercise period may be as useful as depression during exercise to predict coronary artery diseas...
journal_title：Journal of cardiology
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:The clinical usefulness of intracardiac echocardiography (ICE) for the guidance of transseptal puncture procedure during percutaneous left heart bypass support (PLHBS) and percutaneous transvenous mitral commissurotomy (PTMC) was investigated to replace intraoperative transesophageal echocardiography monitoring which ...
journal_title：Journal of cardiology
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:This study qualified the severity and localization of reverse redistribution of technetium-99 m (Tc)-tetrofosmin rest imaging. Both Tc-tetrofosmin and thallium-201 (Tl) rest imaging with early images and delayed images were obtained in the subacute phase of myocardial infarction in 21 patients with first anterior myoc...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:To elucidate the circumstances involving sudden death, deaths among 20,685 male employees of "K" company during a six-year period from April 1981 to March 1987 were reviewed. The subject age ranged from 19 through 59 years, and averaged 38.6 years. Information concerning each death was obtained from the death reports ...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A 61-year-old man was treated medically under a diagnosis of hypertrophic obstructive cardiomyopathy 7 years previously. He was transferred to our hospital because of sudden onset of dyspnea. Chest radiography showed marked pulmonary congestion. Echocardiography revealed hypertrophic obstructive cardiomyopathy, with a...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Coagulation factor Xa (FXa) promotes thrombus formation and exacerbates inflammation via activation of protease-activated receptor (PAR)-2. We tested the hypothesis of whether administration of direct oral anticoagulant, rivaroxaban, would attenuate transverse aortic constriction (TAC)-induced atrial inflamm...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2017.08.007
更新日期：2018-03-01 00:00:00
abstract：:Improvement in left ventricular function following intra-aortic balloon pumping (IABP) in 15 patients (aged 51 to 86 years) after coronary artery bypass grafting was evaluated. Using transesophageal atrial echocardiography, the mitral flow velocity integrals in the rapid filling phase (IntR) and in the contraction pha...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The findings of our recent study entitled, "Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS)" showed that myocardial perfusion single photon emission computed tomography (MPS) can detect coronary artery disease (CAD) and help to predict future cardiac events in ...
journal_title：Journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jjcc.2013.07.006
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Based on the importance of left ventricular (LV) diastolic function in stratification of the cardiac prognosis in patients with systolic heart failure (SHF), we attempted to identify the prognostic impact of Doppler echocardiographic examinations and plasma B-type natriuretic peptide (BNP) concentration. ME...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2008.07.008
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Syndecan-4 is a transmembrane heparan sulfate-carrying glycoprotein that mediates signal transduction pathways activated by growth factors and cell surface receptors, thereby modulating tissue regeneration, angiogenesis, and focal adhesion. The aim of the present study was to determine the clinical use of se...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2011.01.012
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:Aortic valve calcification (AVC) reflects the state of aortic valve sclerosis (AVS), which is a precursor to aortic valve stenosis (AS). Therefore, we investigated the presence of AVC in patients who underwent coronary computed tomography angiography (CTA), which is an effective tool for evaluating early-stag...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2015.08.010
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:On March 11, 2011, the Tohoku district was struck by the most powerful known earthquake to hit Japan. Although stress-induced heart diseases rise after strong psychosocial stress, little is known about the characteristics of heart failure (HF) caused by psychosocial stress related to earthquakes. METHODS:We...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2013.02.015
更新日期：2013-07-01 00:00:00
abstract：:To ascertain the optimal time for surgery in chronic aortic regurgitation (AR), 66 patients with and without surgical correction were reviewed from the standpoint of left ventricular (LV) function based on their serial echocardiographic studies. Aggravation of the clinical status was usually associated with enlarged L...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:From April 1987 to October 1989, 32 patients with mitral stenosis (MS) were treated, of whom percutaneous transvenous mitral commissurotomy (PTMC) was performed in 14. PTMC was indicated by the surgeons in 5 patients including 1) 2 patients who refused reoperation, 2) one with early gastric cancer, 3) one with severe ...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:To assess the relative importance of the anatomical characteristics of the coronary artery distribution and the sites of the arterial stenoses in relation to infarct size, 21 patients with old myocardial infarction and angiographically-proven 90% or greater stenoses (AHA classification) of one of the major coronary ar...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND:Two-dimensional (2D) echocardiography is routinely used in evaluating patients with mitral valve prolapse but requires a systematic examination for accurate assessment of the involved lesion of mitral valve prolapse, because the sonographer is required to mentally reconstruct two-dimensional images into thre...
journal_title：Journal of cardiology
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Apixaban, one of the non-vitamin K antagonist oral anticoagulants, was reported to be effective and safe in stroke prevention in patients with atrial fibrillation (AF) based on the global randomized clinical trial, but data are limited on the efficacy and safety of apixaban in Japanese elderly patients. MET...
journal_title：Journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jjcc.2015.12.006
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Paroxysmal nocturnal dyspnea (PND) is a common symptom for patients with acute decompensated heart failure (ADHF). Some symptoms of PND are similar to those of sleep apnea (SA) which might be associated with overnight worsening hemodynamics in failing hearts. However, the association between PND, SA, and ove...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.jjcc.2012.12.010
更新日期：2013-05-01 00:00:00
abstract：:Whether beneficial hemodynamic effects of cardiovascular drugs are due to changes in the inotropic or loading conditions has been difficult to determine in clinical settings. In this study, the end-systolic pressure-volume relationship, known as a load-independent measurement of cardiac contractility, was obtained by ...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Heart failure (HF) occurs across the entire range of left ventricular (LV) ejection fractions (EF), not just reduced EF. Nearly half or more patients presenting with HF have a preserved EF>0.50 (HFpEF). Diastolic dysfunction is apparent in all patients with HF, regardless of EF. A preserved EF indicates that the end-d...
journal_title：Journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jjcc.2013.02.017
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:The relationship between plasma low-density lipoprotein (LDL) cholesterol and the risk of coronary artery disease (CAD) is known, but the other characteristics of LDL, particularly particle size and density, are unclear. The relationship between small dense LDL phenotype and non-diabetic, normocholesterolemi...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:To determine whether patients with syndrome X suffer from myocardial ischemia, coronary sinus oxygen saturation was continuously measured during pacing loading in 31 patients. Subjects were categorized by groups as syndrome X (11 patients), effort angina (14), and old myocardial infarction and valvular heart disease (...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:To determine the risk factors for restenosis, 170 patients with 245 stenotic lesions who underwent follow-up coronary angiography after successful coronary angioplasty (PTCA) were evaluated. The mean angiographic follow-up period was 116 +/- 39 days (+/- SD). Restenosis was defined according to 3 criteria: 1) greater ...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:A 42-year-old male was hospitalized in the surgical ward for abdominal pain due to stenosis of the splenic flexure of the colon and abscess around the stenosis. After segmental colectomy, the patient received intravenous continuous infusion of trimetaphan (Arfonad) to control his blood pressure. Twenty hours later, he...
journal_title：Journal of cardiology
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
