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Muscarinic acetylcholine receptor binding affinities of pethidine analogs.

Abstract：

:A series of pethidine analogs were synthesized and their affinities for the [(3)H]N-methyl-scopolamine (NMS) binding site on muscarinic acetylcholine receptors (mAChRs) were determined using M1, M3 or M5 human mAChRs expressed by Chinese hamster ovary (CHO) cell membranes. Compound 6b showed the highest binding affinities at M1, M3 and M5 mAChRs (Ki=0.67, 0.37, and 0.38 μM, respectively).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee NR,Zhang X,Darna M,Dwoskin LP,Zheng G

doi

10.1016/j.bmcl.2015.10.029

subject

Has Abstract

pub_date

2015-11-15 00:00:00

pages

5032-5

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30138-4

journal_volume

25

pub_type

杂志文章

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