Abstract：
:The prevalence of obesity in long-term survivors with complex congenital heart disease may be increasing, and little is known about the timing and onset of weight gain and growth patterns in these high-risk patients. Prevalence rates of overweight/obesity and longitudinal changes in body mass index (BMI) with age were determined in 606 patients with Fontan circulation seen at a tertiary care cardiology center from 1992 to 2012. The number of clinic encounters (n) was stratified by age group (n = 401, 2-5 years; n = 333, 6-11 years; n = 217, 12-19 years; and n = 129, >20 years). Among adults, 39% were overweight/obese at last clinic visit; 22% overweight, and 17% obese. Childhood anthropometric data were available for 82 adults, of which 15% (n = 12/82) were overweight/obese in childhood. The likelihood of being overweight/obese as an adult was three times higher if there was a BMI ≥ 85th percentile in childhood (CI 2.1-4.5, P < 0.01). Overweight/obesity in adulthood was associated with lower heart failure rates (4 vs. 19%, P = 0.03). Pediatric rates of overweight/obesity were comparable to national data (NHANES 2011-2012) in every age group: at 2-5 years, (25 vs. 23%), 6-11 years (26 vs. 34%), and 12-19 years (15 vs. 35%). Systolic blood pressure was higher in overweight/obese children as young as 2-5 years of age. Childhood and adult survivors with Fontan circulation have high rates of overweight/obesity. Childhood obesity is a strong predictor of future adiposity and is linked to changes in systolic blood pressure at a very young age.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Chung ST,Hong B,Patterson L,Petit CJ,Ham JNdoi
10.1007/s00246-015-1265-7subject
Has Abstractpub_date
2016-01-01 00:00:00pages
192-200issue
1eissn
0172-0643issn
1432-1971pii
10.1007/s00246-015-1265-7journal_volume
37pub_type
杂志文章abstract：:To reveal the association between DNMT1 polymorphisms and congenital heart disease (CHD) in child patients, a total of 224 CHD child patients as well as 199 healthy individuals were enrolled in the present study. The DNA was extracted from whole blood, and four SNPs including rs16999593, rs2228612, rs2288349 and rs104...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1093-9
更新日期：2015-06-01 00:00:00
abstract：:Rehospitalization following pediatric heart transplantation is common. However, existing data remain somewhat limited. Using a novel linkage between administrative and clinical databases, pediatric heart transplant (HT) recipients from 29 centers who survived to discharge were retrospectively reviewed to determine the...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02326-x
更新日期：2020-03-01 00:00:00
abstract：:We measured the coronary flow reserve in a 13-year-old girl with the rare anomaly of an absent left circumflex coronary artery. Although the coronary flow volume of the right coronary artery was at the same level as that of the left anterior descending coronary artery, the coronary flow reserve of the patient's right ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010188
更新日期：2001-03-01 00:00:00
abstract：:This study aimed to assess the impact of integrating a simulation-based education module into an extracorporeal membrane oxygenation (ECMO) curriculum on novice learners and to test the duration of time that skills obtained during this training exercise were retained. The authors hypothesized that multidisciplinary, s...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0490-6
更新日期：2013-03-01 00:00:00
abstract：:Color-coded two-dimensional (2D) echocardiography confirmed the presence of severe congenital mitral regurgitation in an 8-month-old infant. Intraoperative inspection revealed an isolated perforation in the anterior leaflet. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02239570
更新日期：1990-04-01 00:00:00
abstract：:We report a case of isolated ventricular inversion in a 42-year-old woman. This rare congenital cardiac anomaly was corrected by an intraatrial baffle procedure. She also underwent left-sided double-chamber endocardial pacemaker implantation for postoperative tachycardia bradycardia syndrome. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0583-3
更新日期：2004-09-01 00:00:00
abstract：:Children with congenital heart defects often demonstrate a reduced capacity for exercise, even after surgical intervention. Forty subjects, with various heart defects, completed a 5-year study to evaluate the impact of a postoperative training program on their physical exercise capacity. All of the patients were signi...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02238841
更新日期：1990-07-01 00:00:00
abstract：:Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical correction of an anomalous left coronary artery arising fro...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-015-1120-x
更新日期：2015-04-01 00:00:00
abstract：:Human pluripotent stem cells (hPSCs) offer a multifaceted platform to study cardiac developmental biology, understand disease mechanisms, and develop novel therapies. Remarkable progress over the last two decades has led to methods to obtain highly pure hPSC-derived cardiomyocytes (hPSC-CMs) with reasonable ease and s...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-019-02165-5
更新日期：2019-10-01 00:00:00
abstract：:Congenital diverticulum of the left ventricle, a rare malformation, is usually associated with midline thoracoabdominal defect. We describe a case with congenital left ventricular diverticulum presenting as an isolated lesion. The lesion was suspected on two-dimensional echocardiography and was confirmed by cardiac ca...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02524804
更新日期：1996-07-01 00:00:00
abstract：:The aim of the study is to identify reliable quantitative fetal echocardiographic predictors for postnatal development of coarctation (CoA). In this retrospective study, we included 65 fetuses with a prenatally suspected, isolated CoA, born 2010-2018. Dimensions of the cardiac structures, aortic, and ductal arches exp...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02509-6
更新日期：2020-12-23 00:00:00
abstract：:We describe two cases of left-side pulmonary vein obstruction observed after the arterial switch operation (Jatene) for D-transposition of the great arteries. This appears to be related to left-sided pulmonary vein obstruction occurring coincidently with D-transposition of the great arteries, rather than a consequence...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900180
更新日期：1997-07-01 00:00:00
abstract：:For adults with sickle cell disease (SCD), cardiac changes are well described and may account for up to one-fourth of disease-related mortality. Much less is known about heart disease in pediatric SCD patients. This retrospective study analyzed a contemporary cohort of children with SCD followed at a single tertiary c...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0587-y
更新日期：2013-04-01 00:00:00
abstract：:Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare condition. The majority of cases present with impaired left ventricular function. We report on a premature infant who was diagnosed at a gestational age near term with ALCAPA during routine cardiac examination. The patient showed...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0878-z
更新日期：2006-03-01 00:00:00
abstract：:Interventional occluder implantation has become the preferred mode of treatment in children with clinically significant atrial septal defect (ASD). The continuous increase in the number of patients treated calls for long-term data on device integrity and biocompatibility. We report a child who underwent successful int...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-010-9757-y
更新日期：2010-10-01 00:00:00
abstract：:With the advent of cardiac magnetic resonance imaging and high-resolution echocardiography, cardiac catheterization is unnecessary in clinical protocols in the "routine" single ventricle patient. Catheterization adds little to clinical care in these cases, and there are significant risks and costs associated with it. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-004-0960-6
更新日期：2005-03-01 00:00:00
abstract：:To examine factors associated with low high-density lipoprotein cholesterol (HDL-C) levels among middle school children. HDL-C levels were the primary outcome of interest. A total of 1,104 middle-school children (mean age 11.6 years, 51.2% female) were included in this analysis, of whom 177 (16%) had an HDL-C level ≤4...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-013-0814-1
更新日期：2014-03-01 00:00:00
abstract：:Mammalian cardiomyocytes withdraw from the cell cycle soon after birth. This process is called terminal differentiation. The c-kit, a receptor tyrosine kinase, is expressed on cardiomyocytes immediately after birth but for only a few days. In mice with genetic c-kit dysfunction, adult cardiomyocytes are phenotypically...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9366-1
更新日期：2009-07-01 00:00:00
abstract：:Congenital left ventricular diverticulum is a rare cardiac malformation. The incidence of left ventricular diverticulum is reported to be 0.05% of all congenital heart malformations. This case series comprised three infants with the diagnosis of congenital left ventricular diverticulum determined by echocardiography. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0153-7
更新日期：2012-04-01 00:00:00
abstract：:A 6-year-old girl with type 3 long QT syndrome was safely and successfully implanted with an implantable cardioverter-defibrillator (ICD) system. Prior to implantation, she had experienced uncontrollable life-threatening arrhythmia in spite of high-dose administration of mexiletine. An ICD coil lead for transvenous us...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0065-y
更新日期：2011-10-01 00:00:00
abstract：:The hypothesis that mild recurrent aortic obstruction produces subtle changes in ambulatory blood pressure was investigated by performing 24-hour monitoring on 11 postoperative coarctation patients. Patients (age 16.1 +/- 2.7 years) were compared with normal controls (age 15.7 +/- 2.5 years, n = 15). Surgery (end-to-e...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00794187
更新日期：1995-07-01 00:00:00
abstract：:This study aimed to clarify the characteristics of pulmonary arterial resistance (Rp)-compliance (Cp) coupling in individuals with Down syndrome (DS), who have increased risks of pulmonary arterial hypertension (PAH). We performed cardiac catheterization before and after corrective surgery in 85 DS infants and 85 cont...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02080-9
更新日期：2019-04-01 00:00:00
abstract：:Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-011-9889-8
更新日期：2011-03-01 00:00:00
abstract：:Inhaled nitric oxide (NO) has been used in the preoperative evaluation of patients with congenital heart disease and pulmonary hypertension. The purpose of this study was to characterize responses in pulmonary vascular resistance (PVR) to oxygen and increasing doses of NO during cardiac catheterization and to determin...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0767-5
更新日期：2005-09-01 00:00:00
abstract：:Myocardial contractility and relaxation are highly dependent on calcium homeostasis. Immature myocardium, as in pediatric patients, is thought to be more dependent on extracellular calcium for optimal function. For this reason, intravenous calcium chloride infusions may improve myocardial function in the pediatric pat...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1322-2
更新日期：2016-03-01 00:00:00
abstract：:Anomalous origin of left pulmonary artery (ALPA) from aorta with atrial septal defect (ASD) is a rare congenital cardiac malformation. We report a case of ALPA from the aorta with ASD in a 1.8-kg baby. Repair was needed at an early age due to progressive congestive heart failure. Surgical correction was performed with...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9234-z
更新日期：2008-07-01 00:00:00
abstract：:Different devices have been used for percutaneous closure of ventricular septal defects (VSDs). Over the past 6 months, we have used the Amplatzer duct occluder for VSDs associated with tunnel-shaped aneurysm in three patients here at our institution. Due to the anatomic resemblance between such VSDs and the duct occl...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-007-9092-0
更新日期：2008-03-01 00:00:00
abstract：:The objective of this study was to evaluate the incidence of pre-existing catheterization left pulmonary artery (LPA) gradients and correlation of these gradients with later LPA stenosis after successful patent ductus arteriosus (PDA) occlusion. We performed a single-center review of 130 patients with PDA closure from...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-009-9448-8
更新日期：2009-10-01 00:00:00
abstract：:As our ability to diagnosis cardiomyopathy matures and genetic testing becomes more widespread, there has been an increase in the number of children followed for cardiomyopathy. The purpose of this study was to compare health-related quality of life (HRQoL) between children with cardiomyopathy and healthy controls and...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-1042-z
更新日期：2015-03-01 00:00:00
abstract：:The genetic basis of congenital heart disease remains unknown in most of the cases. Recently, a novel mouse model shed new light on the role of CCN1/CYR61, a matricellular regulatory factor, in cardiac morphogenesis. In a candidate gene approach, we analyzed a cohort of 143 patients with atrial septal defects (ASD) by...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-1001-8
更新日期：2015-02-01 00:00:00
