Abstract:
AIMS:Type 2 diabetes mellitus (T2DM) is characterized by both decreased insulin sensitivity and impaired insulin secretion. The 2 phases of insulin secretion are the first-phase insulin secretion (1st ISEC) and the second-phase insulin secretion. In this study, we tried to build clinical-metabolic models to predict the 1st ISEC deficiency (ISEC-D) in non-diabetic subjects so that early intervention could be started. DESIGN AND SETTINGS:A cross-sectional study was conducted in the clinical research department of a hospital in Taiwan from 2010 to 2011. METHODS:A total of 89 subjects without diabetes were enrolled in the study, including 49 with normal glucose tolerance and 40 pre-diabetes. A frequently sampled intravenous glucose tolerance test was done to determine insulin sensitivity and acute insulin response after the glucose load, which is regarded as the 1st ISEC. Subjects with the lowest tertile of the 1st ISEC were defined as ISEC-D. From the simplest to the most complex, 3 models were build: Model 0: fasting plasma glucose (FPG); Model 1: FPG + body mass index (BMI) + High-density lipoprotein cholesterol (HDL-C); Model 2: Model 1+ fasting plasma insulin (FPI). The area under the receiver-operating characteristic curve (aROC curve) was used to determine the predictive power among these models. An optimal cut-off value was also determined. RESULTS:Among metabolic syndrome (MetS) components (FPG, BMI, and HDL-C), FPG had the greatest aROC curve (70.9%). Moreover, the aROC curves of Models 1 and 2 were all significantly greater than that of FPG (80.4% and 82.3%, respectively). Their aROC curves were also greater than that of the homeostasis model assessment b-cell (HOMA-b) function, which is the most commonly used method to evaluate b-cell function. CONCLUSION:By using only MetS components, ISEC-D could be predicted with an acceptable sensitivity of 84.0% and a specificity of 74.0%. However, after adding FPI into the Model, the predictive power of Model 2 did not increase. These model-derived MetS components could be widely used in clinical settings and early detection of non-diabetic subjects with high risk for T2DM.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Lin JDdoi
10.5144/0256-4947.2015.138subject
Has Abstractpub_date
2015-03-01 00:00:00pages
138-45issue
2eissn
0256-4947issn
0975-4466journal_volume
35pub_type
杂志文章abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder which causes neonatal jaundice in most cases, and under certain conditions, can cause a spectrum of hemolytic manifestations. OBJECTIVE:To determine the local prevalence of G6PD deficiency in newborns. DESIGN:Cross-sectional. SETT...
journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.2017.362
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.151
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abstract::Thiamine-responsive megaloblastic anemia syndrome is a rare autosomal recessive disorder defined by the occurrence of megaloblastic anemia, diabetes mellitus, and bilateral sensorineural deafness, responding in varying degrees to thiamine treatment. We report a precedence case for the treatment of deafness associated ...
journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.45
更新日期:2013-01-01 00:00:00
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.1993.246
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journal_title:Annals of Saudi medicine
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更新日期:1992-03-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章,随机对照试验
doi:10.5144/0256-4947.2014.18
更新日期:2014-01-01 00:00:00
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.2017.1
更新日期:2017-01-01 00:00:00
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更新日期:2009-07-01 00:00:00
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journal_title:Annals of Saudi medicine
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更新日期:2017-11-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.214
更新日期:2018-05-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2007.25
更新日期:2007-01-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章,评审
doi:10.5144/0256-4947.2006.288
更新日期:2006-07-01 00:00:00
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.1995.563
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.2015.456
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journal_title:Annals of Saudi medicine
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更新日期:2004-03-01 00:00:00
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.2002.177
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doi:10.5144/0256-4947.2002.312
更新日期:2002-09-01 00:00:00
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journal_title:Annals of Saudi medicine
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更新日期:2019-11-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.334
更新日期:2013-07-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.162
更新日期:2012-03-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2019.42
更新日期:2019-01-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.352
更新日期:2018-09-01 00:00:00