Emerging global epidemic of obesity: the renal perspective.

Abstract:

:Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease--a widely prevalent but often silent condition. Obesity carries elevated risks of cardiovascular morbidity and mortality besides having an array of metabolic complications. Maladaptive glomerular hemodynamics with increased intraglomerular pressure in association with vasoactive, fibrogenic substances released from adipocytes, in addition to cytokines and hormones, are the key factors in the causation of renal injury and the progression of nephron loss among obese subjects.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Saxena AK

doi

10.5144/0256-4947.2006.288

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

288-95

issue

4

eissn

0256-4947

issn

0975-4466

pii

04-283

journal_volume

26

pub_type

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