Clinicopathological study of male breast carcinoma: 24 years of experience.

Abstract:

BACKGROUND AND OBJECTIVES:Because breast cancer in men is rare, few patients are available for prospective studies. To learn more about its epidemiology, risk factors, clinical features, genetics and pathology in our country, we conducted a retrospective study of all cases seen in recent decades at our institution. PATIENTS AND METHODS:We identified each case of male breast cancer in the database at the Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India, between the years 1983 to 2007. RESULTS:We identified only 32 cases of male breast cancer over the 24-year period. Male breast cancer accounted for 32 (2.8%) of 1141 resected breast specimens, which included all breast lesions and 32 (4.1%) of 780 breast cancer cases. Of the 32 cases, 20 (62.5%) had various associated risk factors. Invasive ductal carcinoma was seen in 30 cases (93.7%). Of 20 cases that underwent molecular studies, 16 (80%) patients had estrogen receptor positivity whereas 14 (70%) had progesterone receptor positivity. Six cases (30%) overexpressed HER2 and p53. The BRCA2 mutation was observed in 4 cases (40%) while no patient presented with the BRCA1 mutation. CONCLUSION:An incidence of 4.1% for male breast cancer indicates that this disease is not as uncommon as presumed in this part of the world. Breast cancer in men seems more frequently to be hormone receptor positive and the BRCA2 mutation confers a significant risk to men.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Shah P,Robbani I,Shah O

doi

10.4103/0256-4947.55314

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

288-93

issue

4

eissn

0256-4947

issn

0975-4466

pii

09-004

journal_volume

29

pub_type

杂志文章
  • Primary breast lymphoma: a pooled analysis of prognostic factors and survival in 93 cases.

    abstract:BACKGROUND:Primary breast lymphoma is a rare disease. The small number of patients and the paucity of data make large-series studies difficult. We conducted a pooled analysis to evaluate the treatment outcome and prognostic factors in patients with primary breast lymphoma. METHODS:In a search of PUBMED and MEDLINE we ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2005.288

    authors: Liu MT,Hsieh CY,Wang AY,Pi CP,Chang TH,Huang CC,Huang CY

    更新日期:2005-07-01 00:00:00

  • Evaluation of anti-ds DNA antibody measurement by using commercial kits for use in a clinical laboratory.

    abstract::Three hundred and seventy-six consecutive antinuclear antibody-positive sera were tested for anti-ds DNA antibody by using three commercial kits which use 125 I recombinant DNA (radioimmunoassay), highly purified calf thymus DNA (enzyme linked immunosorbent assay) and Crithidia lucilliae (immunofluorescence assay) as ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1995.327

    authors: Sheth KV,Alkaff MA,Bahabri SA,El Ramahi KM,Al-Sedairy S,Al-Dalaan AA

    更新日期:1995-07-01 00:00:00

  • Serum sex steroids, gonadotrophins and sex hormone-binding globulin in prostatic hyperplasia.

    abstract:BACKGROUND:Benign prostatic hyperplasia (BPH) develops in elderly males when serum androgens are relatively lower than in healthy younger males, but it is not well understood whether and how sex steroids are altered in prostatic hyperplasia. It is also uncertain whether there is any change in sex steroid levels in male...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2008.174

    authors: Ansari MA,Begum D,Islam F

    更新日期:2008-05-01 00:00:00

  • Sexually transmitted diseases in domestic expatriate workers in Jeddah, Saudi Arabia.

    abstract::This study was conducted to determine the sexually transmitted diseases in domestic expatriate workers (DEWs) screened for pre-employment in the general clinics of a teaching hospital. The study included 1648 domestic expatriate workers who were reviewed by a general practitioner, and who underwent serological tests f...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1997.29

    authors: Hamdi SA,Ibrahim MA

    更新日期:1997-01-01 00:00:00

  • Laparoscopic vs. open adrenalectomy: experience at King Faisal Specialist Hospital and Research Centre, Riyadh.

    abstract:BACKGROUND:The laparoscopic approach for adrenalectomy is now widely accepted and preferred over the conventional open approach. We describe our experience of adreanalectomy and compare the results of open and laparoscopic approach. PATIENTS AND METHODS:From March 1999 to March 2002, we performed 23 adrenalectomies. A...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2003.36

    authors: Yousef HB,Al Zahrani A,Ahmed M,Al Arifi A,Mahfouz A,Hussain R,Al-Sobhi S

    更新日期:2003-01-01 00:00:00

  • Epidemiology of sickle cell disease in Saudi Arabia.

    abstract::Sickle cell disease (SCD) is an autosomal recessive disorder characterized by production of abnormal hemoglobin S and is associated with high morbidity and mortality. Information about the prevalence of SCD in Saudi Arabia is patchy and probably underestimated, but studies have reported that SCD is a relatively common...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章,评审

    doi:10.4103/0256-4947.81540

    authors: Jastaniah W

    更新日期:2011-05-01 00:00:00

  • Appendiceal ascariasis in children.

    abstract:BACKGROUND:The propensity of Ascaris lumbricoides to wander leads to varied surgical complications in the abdomen. Wandering A lumbricoides may sometimes reach the vermiform appendix and its presence there may remain silent or incite pathology. Our aim was to study ascariadial appendicitis. METHODS:Over a period of 3 ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.4103/0256-4947.59380

    authors: Wani I,Maqbool M,Amin A,Shah F,Keema A,Singh J,Kitagawa M,Nazir M

    更新日期:2010-01-01 00:00:00

  • Myocardial perfusion scintigraphy: techniques, interpretation, indications and reporting.

    abstract::Myocardial perfusion single photon emission-computed tomography (MPS) has been one of the most important and common non-invasive diagnostic cardiac test. Gated MPS provides simultaneous assessment of myocardial perfusion and function with only one study. With appropriate attention to the MPS techniques, appropriate cl...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章,评审

    doi:10.4103/0256-4947.87101

    authors: Fathala A

    更新日期:2011-11-01 00:00:00

  • Prevalence of bicuspid aortic valve and mitral valve prolapse in a healthy Saudi population and the clinical implications of their association.

    abstract::In this study, 103 Saudi males and 172 Saudi females were referred for medical check-up for employment purposes and/or as undergraduate students. Clinical evaluation of all participants included full cardiovascular examination, with the following investigations being performed: ECG, chest x-ray, and cross-sectional ec...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1996.417

    authors: Nouh MS,Al-Nozha MM,Taha A,Al-Shamiri M,Arafah MR,Akhter JM,Allam AR,Yamany HA

    更新日期:1996-07-01 00:00:00

  • A comparative ultrasound and plain abdominal x-ray: Evaluation of non-classical clinical cases of appendicitis.

    abstract::A prospective study of 109 patients with non-classical symptoms of appendicitis using the standard ultrasound (US) machine and plain abdominal x-rays demonstrated that US was superior to plain x-ray with a sensitivitiy, specificity and overall accuracy of 89%, 96% and 91%, respectively as compared with plain x-ray wit...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1993.41

    authors: Makanjuola D,Al-Qasabi Q,Malabarey T

    更新日期:1993-01-01 00:00:00

  • Outcome after ileal pouch-anal anastomosis for familial adenomatous polyposis compared to mucosal ulcerative colitis in a Middle Eastern population.

    abstract:BACKGROUND AND OBJECTIVES:To compare the complications and outcome after ileal pouch-anal anastomosis (IPAA) for mucosal ulcerative colitis (MUC) and familial adenomatous polyposis (FAP). DESIGN AND SETTINGS:This is a retrospective study. The study was conducted at a single tertiary referral center. METHODS:All patie...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.268

    authors: Al-Sanea N,Alfaifi J,Homoud SA,Abduljabbar A,Hibbert D,Ashari L

    更新日期:2013-05-01 00:00:00

  • Body mass index in Saudi Arabian children and adolescents: a national reference and comparison with international standards.

    abstract:BACKGROUND AND OBJECTIVES:Because there are no reference standards for body mass index (BMI) in Saudi children, we established BMI reference percentiles for normal Saudi Arabian children and adolescents and compared them with international standards. SUBJECTS AND METHODS:Data from a stratified multistage probability s...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.4103/0256-4947.55162

    authors: Al Herbish AS,El Mouzan MI,Al Salloum AA,Al Qureshi MM,Al Omar AA,Foster PJ,Kecojevic T

    更新日期:2009-09-01 00:00:00

  • Low baseline proBNP associated with increased risk of intraoperative hypotension during spinal anaesthesia for cesarean delivery.

    abstract:BACKGROUND AND OBJECTIVES:Brain natriuretic peptide (BNP) has a role in the regulation of body fluid volume and blood pressure (BP). BNP remains within a normal range during spinal anaesthesia (SA) in patients undergoing cesarean delivery. However, the effect of BNP on changes in BP during the perioperative period has ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2015.248

    authors: Birtay T,Genctoy G,Saba T

    更新日期:2015-05-01 00:00:00

  • Fiberoptic, conventional and combination phototherapy for treatment of nonhemolytic hyperbilirubinemia in neonates.

    abstract::The objective of this prospective, randomized study was to compare the effectiveness of fiberoptic, conventional and a combination phototherapy in decreasing bilirubin concentrations in neonatal nonhemolytic hyperbilirubinemia. Forty-six infants who were 36 weeks' gestation and more were randomly assigned to fiberopti...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1996.633

    authors: Al-Alaiyan S

    更新日期:1996-11-01 00:00:00

  • Characteristics of Saudi patients with congestive heart failure and adherence to management guidelines in a tertiary hospital in Riyadh.

    abstract:BACKGROUND AND OBJECTIVES:There is limited data available on the characteristics of local Saudi patients diagnosed with congestive heart failure (CHF) and on their adherence to guidelines for managing the disease. This study aimed to fill this gap. DESIGN AND SETTING:Retrospective study of patients treated at King Abd...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2012.583

    authors: Alqahtani M,Alanazi T,Binsalih S,Aljohani N,Alshammari M,Ashagag A,Abdullah M,Buabbas S,Abdulbaqi M

    更新日期:2012-11-01 00:00:00

  • The pattern of diabetic nephropathy among Saudi patients with noninsulin-dependent diabetes mellitus.

    abstract::There were no studies on the different stages of diabetic nephropathy in Saudi Arabia, particularly the earliest stages. We have therefore investigated the frequency of occurrence of varying degrees of proteinuria including microalbuminuria in noninsulin-dependent diabetes mellitus (NIDDM) Saudi patients as well as th...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1995.120

    authors: Huraib S,Abu-Aisha H,Sulimani RA,Famuyiwa FO,Al-Wakeel J,Askar A,Sulimani F

    更新日期:1995-03-01 00:00:00

  • The monitoring of potential long-term comlications in treated adult cancer patients.

    abstract::A wide variety of long-term complications may be noted following conventional cancer treatment. These include overwhelming postsplenectomy sepsis syndrome, central and peripheral nervous system toxicity, cardiovascular complications, chronic liver damage, and secondary malignancy. Follow-up monitoring usually incorpor...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1997.622

    authors: Brigden ML

    更新日期:1997-11-01 00:00:00

  • Head and neck cancer in a referral center in Asir region.

    abstract::This study looks at the incidence of head and neck cancer in the Southwest Region of the Kingdom of Saudi Arabia (Asir Region). There were a total of 204 newly diagnosed patients seen at Asir Central Hospital between 1987 and 1992; 113 males and 91 females. All were Saudi patients. Frequency at various sites with refe...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1994.383

    authors: Al-Ghamdi SA,Malatani T,Kameswaran M,Khurana P

    更新日期:1994-09-01 00:00:00

  • Thyroglossal duct remnants.

    abstract::Case records of 33 patients treated for thyroglossal duct lesions at the King Fahd Hospital of the University, Al-Khobar between 1982G and 1992G were reviewed. There were 22 males and 11 females, their ages ranging between one and 35 years. Sixteen patients presented as cysts and 17 as sinuses. All cases were diagnose...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1994.136

    authors: Al-Arfaj A

    更新日期:1994-03-01 00:00:00

  • Secondary metabolic syndrome: the frequency of factors which may underlie the parameters of metabolic syndrome.

    abstract:BACKGROUND AND OBJECTIVES:Each of the metabolic syndrome (MetS) components (central obesity, hypertriglyceridemia, hypertension, low high-density lipoprotein cholesterol, and insulin resistance) may arise from an underlying disease or factors such as hormonal or pharmacological factors. These components arising seconda...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.566

    authors: Oguz A,Mesci B,Sagun G,Kilic DC,Yetkin DO,Akalin A

    更新日期:2013-11-01 00:00:00

  • Cutaneous T-cell lymphoma in Saudi Arabia: retrospective single-center review.

    abstract:BACKGROUND:Cutaneous T-cell lymphoma (CTCL) is an uncommon disease with various clinical presentations. The hypopigmented type is more common in individuals with a dark skin complexion. Moreover, childhood CTCL is more common in Mediterranean populations in comparison to the West. OBJECTIVE:To describe CTCL in the Sau...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2017.212

    authors: Binamer Y

    更新日期:2017-05-01 00:00:00

  • Human orf (ecthyma contagious) a report of two cases from Saudi Arabia.

    abstract::Two cases of orf occuring in one family are reported. The patients developed characteristic skin lesions one week after sustaining cuts while slaughtering a sheep. The diagnosis of orf was confirmed by electron microscopy which revealed numerous large oval virus particle characteristics of parapox virus. This we belie...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1986.49

    authors: Roy-Boulos AM,Akhtar M,Bendl B

    更新日期:1986-01-01 00:00:00

  • Prevalence of antibodies to hepatitis C virus in Saudi patients with chronic liver disease.

    abstract::The prevalence of antibodies to hepatitis C virus (anti-HCV) has been measured in 113 Saudi patients with chronic liver diseases. Twenty-five percent of 20 patients with hepatocellular carcinoma (HCC) were positive for anti-HCV and 29.7% of 38 patients with cirrhosis and 27.3% of 33 patients with liver fibrosis, respe...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1991.497

    authors: Fakunle YM,Al-Mofarreh M,El-Drees AZ,El-Karamany WM,Ezzat HO,Ballesteros MN,Khawaji MZ

    更新日期:1991-09-01 00:00:00

  • Predicting glucose intolerance with normal fasting plasma glucose by the components of the metabolic syndrome.

    abstract:BACKGROUND:Surprisingly, it is estimated that about half of type 2 diabetics remain undetected. The possible causes may be partly attributable to people with normal fasting plasma glucose (FPG) but abnormal postprandial hyperglycemia. We attempted to develop an effective predictive model by using the metabolic syndrome...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2007.339

    authors: Pei D,Lin JD,Wu DA,Hsieh CH,Hung YJ,Kuo SW,Kuo KL,Wu CZ,Li JC

    更新日期:2007-09-01 00:00:00

  • Coexistence of chronic lymphocytic leukemia and polycythemia vera: a case report and review of the literature.

    abstract::Polycythemia vera is a Philadelphia chromosome-negative myeloproliferative neoplasm. Chronic lymphocytic leukemia is a monoclonal expansion of a CD5+ CD19+ B lymphocytes. Chronic myeloproliferative neoplasms may coexist with indolent B-cell malignant lymphomas of various types. The association of chronic lymphocytic l...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章,评审

    doi:10.5144/0256-4947.2016.364

    authors: Korkmaz S,Kulakoglu S,Gorkem H,Aygun B,Cetinkaya A

    更新日期:2016-09-01 00:00:00

  • Clinical and radiological characteristics of Chinese patients with hepatic epithelioid hemangioendothelioma.

    abstract:BACKGROUND AND OBJECTIVES:To study clinical features, imaging findings, and prognosis of hepatic epithelioid hemangioendothelioma (HEHE) in Eastern Hepatobiliary Surgical Hospital and to improve the level of recognition and preoperative diagnosis of HEHE. DESIGN AND SETTINGS:This is a retrospective study. The study wa...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.334

    authors: Fan F,Yang X,Zhu B,Zhang Y

    更新日期:2013-07-01 00:00:00

  • Endobronchial valve vs coil for lung volume reduction in emphysema: results from a tertiary care centre in Turkey.

    abstract:BACKGROUND:Bronchoscopic lung volume reduction (BLVR) by either the endobronchial valve (EBV) or coil (EBC) procedure is recommended for severe emphysematous patients. BLVR applications generally help healthy lung areas ventilate more comfortably by reducing the hyperinflation and improving the contraction capacity of ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2020.469

    authors: Dumanli A,Metin B,Gunay E

    更新日期:2020-11-01 00:00:00

  • Q192R polymorphism in the PON1 gene and familial hypercholesterolemia in a Saudi population.

    abstract:BACKGROUND:Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2017.425

    authors: Alharbi KK,Alnbaheen MS,Alharbi FK,Hasanato RM,Khan IA

    更新日期:2017-11-01 00:00:00

  • Stress and coping among consultant physicians working in Saudi Arabia.

    abstract:BACKGROUND:Exposure to stressful working conditions without adequate stress-coping strategies may lead to stress and even psychiatric morbidity. There are a dearth of studies on stress-coping strategies among consultant physicians in the Arabian Gulf. OBJECTIVES:Determine stress-coping strategies among consultants in ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2018.214

    authors: Alosaimi FD,Alawad HS,Alamri AK,Saeed AI,Aljuaydi KA,Alotaibi AS,Alotaibi KM,Alfaris EA

    更新日期:2018-05-01 00:00:00

  • Extracorporeal shock wave lithotripsy in the treatment of ureteric stones: experience from Tawam Hospital, United Arab Emirates.

    abstract:BACKGROUND:The optimal treatment of ureteric stones, especially the lower ureteric stone, remains controversial. The purpose of this study was to evaluate the role of extracorporeal shock wave lithotripsy (ESWL) in the management of ureteric stones. MATERIALS AND METHODS:A total of 99 patients with ureteric stones at ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2002.18

    authors: Ghafoor M,Halim A

    更新日期:2002-01-01 00:00:00