Abstract:
BACKGROUND:Surprisingly, it is estimated that about half of type 2 diabetics remain undetected. The possible causes may be partly attributable to people with normal fasting plasma glucose (FPG) but abnormal postprandial hyperglycemia. We attempted to develop an effective predictive model by using the metabolic syndrome (MeS) components as parameters to identify such persons. SUBJECTS AND METHODS:All participants received a standard 75-g oral glucose tolerance test, which showed that 106 had normal glucose tolerance, 61 had impaired glucose tolerance, and 6 had diabetes-on-isolated postchallenge hyperglycemia. We tested five models, which included various MeS components. Model 0: FPG; Model 1 (clinical history model): family history (FH), FPG, age and sex; Model 2 (MeS model): Model 1 plus triglycerides, high-density lipoprotein cholesterol, body mass index, systolic blood pressure and diastolic blood pressure; Model 3: Model 2 plus fasting plasma insulin (FPI); Model 4: Model 3 plus homeostasis model assessment of insulin resistance. A receiver-operating characteristic (ROC) curve was used to determine the predictive discrimination of these models. RESULTS:The area under the ROC curve of the Model 0 was significantly larger than the area under the diagonal reference line. All the other 4 models had a larger area under the ROC curve than Model 0. Considering the simplicity and lower cost of Model 2, it would be the best model to use. Nevertheless, Model 3 had the largest area under the ROC curve. CONCLUSION:We demonstrated that Model 2 and 3 have a significantly better predictive discrimination to identify persons with normal FPG at high risk for glucose intolerance.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Pei D,Lin JD,Wu DA,Hsieh CH,Hung YJ,Kuo SW,Kuo KL,Wu CZ,Li JCdoi
10.5144/0256-4947.2007.339subject
Has Abstractpub_date
2007-09-01 00:00:00pages
339-46issue
5eissn
0256-4947issn
0975-4466pii
07-069journal_volume
27pub_type
杂志文章abstract:BACKGROUND:Tocilizumab (TCZ) is a humanized anti-human IL-6R antibody, a novel therapy for rheumatoid arthritis (RA) patients who fail treatment with disease modifying anti-rheumatic drugs (DMARDs) or anti-tumor necrosis factor (anti-TNFs). OBJECTIVE:To assess the safety and efficacy of TCZ monotherapy or in combinati...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,多中心研究
doi:10.5144/0256-4947.2016.190
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Esophageal atresia (EA), with or without tracheoesophageal fistula (TOF) is one of the most correctable fetal anomalies if diagnosed antenatally by serial ultrasound. We retrospectively evaluated antenatal diagnoses by ultrasound of EA with or without TOF at our institution in Saudi Arabia. PATIENTS AND MET...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2003.132
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There are few reports of cutaneous tuberculosis with immunosuppressed states such as HIV, use of immunosuppressants or malignancy. Diagnosis is thus difficult and despite scientific advances such as polymerase chain reaction, it is frequently missed. Although rare, given its worldwide prevalen...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.77495
更新日期:2011-03-01 00:00:00
abstract::Acroangiodermatitis (AAD) (synonym, pseudo-Kaposi sarcoma) is a term that encompasses 2 different conditions: (1) AAD of Mali, which refers to skin lesions that mainly develop bilaterally on the lower extremities of patients with chronic venous insufficiency and is an extreme form of stasis dermatitis and (2) Stewart-...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2014.179
更新日期:2014-03-01 00:00:00
abstract::Since late 1975, the King Faisal Specialist Hospital and Research Centre (KFSH&RC), a tertiary-care hospital in Saudi Arabia, has continuously collected data on its experience in oncology. With 22,836 cancer cases as a base, covering the years between 1976 and 1993, it is intended to present the hospital data obtained...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Congenital heart defects (CHD), which are caused by abnormalities early in fetal life, encompass over 50 diagnoses. Since the detailed etiology is unknown, the geographical distribution of defects might suggest likely risk factors. METHODS:The geographical distribution of 5 865 Saudi Arabian nationals with ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2005.63
更新日期:2005-01-01 00:00:00
abstract::Although cataract surgery is increasingly being performed under local anesthesia in many centers, general anesthesia is preferred for cataract surgery at the King Fahd Hospital of the University (KFHU), Al-Khobar. Ninety two patients who had cataract extraction under general anesthesia at KFHU between October 1988 and...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.13
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Febrile urinary tract infections and pyelonephritis are common in children and frequently lead to hospitalization for management, especially in the child who appears toxic. The American Academy of Pediatrics (AAP) practice parameter on the diagnosis, treatment and evaluation of the initial uri...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,实务指引,评审
doi:10.4103/0256-4947.68549
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Hepatitis B is a disease that is preventable with vaccination. Antibody levels after vaccination may be affected by suppression of the immune system due to cancer therapy. Children with cancer have a high risk of hepatitis B virus (HBV) infection. We aimed to assess the pretreatment immunizati...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.87091
更新日期:2011-11-01 00:00:00
abstract::Adverse cutaneous reactions are rarely seen with antipsychotics. Exanthematous eruptions, skin pigmentation changes, photosensitivity, urticaria, and pruritus have been previously reported. We report a bruise-like rash in a 4-year-old boy with risperidone use. The rash disappeared on discontinuation and then reappeare...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2020.436
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Indeterminate pulmonary nodules (IPNs) are common during initial evaluation of bladder cancer patients. Their significance is still unknown. OBJECTIVE:Determine the significance of indeterminate pulmonary nodules, including their size and number, in muscle-invasive bladder cancer patients before definitive ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2019.42
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Dentists suffer a high prevalence of musculoskeletal disorders (MSDs) but studies are quite limited. The present study was carried out to investigate the prevalence of MSDs among dentists in the Ha'il Region, Saudi Arabia. DESIGN AND SETTINGS:A cross-sectional, questionnaire study was conduct...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2015.456
更新日期:2015-11-01 00:00:00
abstract::Submucosal diathermy of the inferior turbinate (SMDIT) is a generally safe procedure to control inferior turbinate hypertrophy. We present a case of a cerebrospinal fluid (CSF) leak at the craniocervical junction after SMDIT done in another institution. A 27-year-old man presented 3 weeks after undergoing SMDIT with s...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.143
更新日期:2018-03-01 00:00:00
abstract::A series of fine-needle aspiration biopsies performed in 635 children were reviewed. The diagnosis rendered in these patients included malignant lymphoma in 139 (21.9%), Hodgkin's disease, 25 (3.9%); neuroblastoma, 58 (9.1%); Wilms' tumor, 37 (5.8%); Ewing's sarcoma, 32 (5.0%); rhabdomyosarcoma, 25 (3.9%); retinoblast...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.366
更新日期:1991-07-01 00:00:00
abstract::Although the medical literature contains adequate accounts of the pathophysiology of various benign prostatic disorders, it is often necessary to revisit these lesions, to reexamine the relationships between known benign lesions and more sinister, malignant disorders, in the light of new advances in our understanding ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1998.22
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The clinical features of acute myeloblastic leukemia (AML) and its response to therapy in adult patients in Saudi Arabia are not well defined, as only scanty data has been available. This situation will likely continue unless experience with AML is reported from different institutions in the Kingdom. PATIEN...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1998.221
更新日期:1998-05-01 00:00:00
abstract::Neonatal diabetes mellitus is considered a rare disease that is diagnosed in the first six months of life, and can be either transient or permanent. Recent advances in molecular genetics have shown that activating mutations in KCNJ11 (the gene that encodes for the Kir6.2 subunit of the K ATP potassium channel of the p...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.60526
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Fever contributes to a significant number of visits by children to the emergency department (ED), where it is often treated with acetaminophen. The objective of this study was to determine if caregivers give children with fever an accurate dose of acetaminophen and determine factors associated...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.84630
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Cutaneous T-cell lymphoma (CTCL) is an uncommon disease with various clinical presentations. The hypopigmented type is more common in individuals with a dark skin complexion. Moreover, childhood CTCL is more common in Mediterranean populations in comparison to the West. OBJECTIVE:To describe CTCL in the Sau...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.212
更新日期:2017-05-01 00:00:00
abstract::Thyroglossal duct cyst carcinoma is a rare malignancy, with an incidence of 0.7% to 1.6%. Most cases of thyroglossal duct cyst carcinoma are papillary carcinoma, with follicular carcinoma having been rarely reported. In this study, a 33-year-old man presented with a typical thyroglossal duct cyst and underwent surgica...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.305
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Fetal growth is the result of interactions between various factors and can be estimated by ultrasonic measurements. Fetal femur length is a scale for estimating the fetal weight in individual races because fetal growth patterns differ among different races. SUBJECTS AND METHODS:This was a prospective study ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2007.179
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Because breast cancer in men is rare, few patients are available for prospective studies. To learn more about its epidemiology, risk factors, clinical features, genetics and pathology in our country, we conducted a retrospective study of all cases seen in recent decades at our institution. PA...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.55314
更新日期:2009-07-01 00:00:00
abstract::The utilization of therapeutic drug monitoring (TDM) for serum digoxin and theophylline was assessed with respect to the indication, time of sample collection and contribution to patient care. A total of 585 serum drug level determinations of digoxin (275) and theophylline (328) were done in a four month period. Reaso...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.178
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.425
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Total laboratory automation (TLA) is a relatively new way of improving the management of high volume clinical laboratories. TLA may reduce staff, reduce operating costs, decrease testing time and provide enhanced process control. OBJECTIVES:Establish a cost efficient TLA that is less labor intensive, improv...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.352
更新日期:2018-09-01 00:00:00
abstract::This study looks at the incidence of head and neck cancer in the Southwest Region of the Kingdom of Saudi Arabia (Asir Region). There were a total of 204 newly diagnosed patients seen at Asir Central Hospital between 1987 and 1992; 113 males and 91 females. All were Saudi patients. Frequency at various sites with refe...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.383
更新日期:1994-09-01 00:00:00
abstract::Pena-Shokeir phenotype is a unique pattern of lethal multiple congenital anomalies with variable expression. The history of a family in which two sibs conform to Pena-Shokeir phenotype is detailed and substantiates the criteria for definition of the phenotype. The addition of a peculiar ultrasound presentation in the ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.264
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Coronary artery calcification (CAC) is indicated by calcium deposits in the coronary artery wall. Calcification is a component of atherosclerosis and coronary artery disease. Currently, there are no data on calcification in Saudi women at high risk of coronary artery disease. The aim of this st...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2015.298
更新日期:2015-07-01 00:00:00
abstract::A total of 84 cases of primary gastric cancer were diagnosed in the histopathology laboratory of Asir Central Hospital over a five year period (1987 to 1991). Seventy-two patients (86%) were Saudis and 12 cases (14%) were non-Saudis. The mean age of the patients included in this study was 60 years with a range of 22 t...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.195
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Nasal polyposis is a common problem in the eastern province of Saudi Arabia. Since allergic fungal sinusitis (AFS) can present with unilateral or bilateral nasal polyps, it is important to be aware of the prevalence of AFS in patients with nasal polyps. PATIENTS AND METHODS:The medical records of 91 patient...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2009.212
更新日期:2009-05-01 00:00:00