Abstract:
BACKGROUND:The clinical features of acute myeloblastic leukemia (AML) and its response to therapy in adult patients in Saudi Arabia are not well defined, as only scanty data has been available. This situation will likely continue unless experience with AML is reported from different institutions in the Kingdom. PATIENTS AND METHODS:In this retrospective study, the records of 52 adult patients with previously untreated de novo acute myeloblastic leukemia (AML) who were treated at King Khalid University Hospital over a five-year period from January 1989 to December 1993 according to the conventional â3+7â regimen were reviewed. The clinical features of the disease, response to therapy and treatment-related complications were identified. RESULTS:There were 33 males and 19 females with a mean age of 30+/-13 years (mean+/-SD). M 4 and M 5 AML were the predominant French-American-British (FAB) subtypes encountered. Sixty-five percent of patients achieved complete remission (CR). The median duration of the first CR of all analyzable patients was 32 weeks. The median CR duration and survival of patients achieving complete remission who survived through their consolidation treatment was 36 and 49 weeks, respectively. CONCLUSION:Both median duration of the first complete remission and survival compare unfavorably with those reported in the literature despite a comparable remission rate. Infectious complications were frequent and accounted for a significant number of mortalities.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Harakati MS,Al-Momen AM,Ajarim DS,Al-Moharib FI,Al-Theyab A,Fawzy EM,Al-Gwaiz L,Al-Khairy KSdoi
10.5144/0256-4947.1998.221subject
Has Abstractpub_date
1998-05-01 00:00:00pages
221-5issue
3eissn
0256-4947issn
0975-4466pii
18-221journal_volume
18pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:There is rising interest in quality of life (QOL) research in Arabian countries. The aim of this study was to assess in a nationwide sample of Kuwaiti subjects the reliability and validity of the World Health Organization Quality of Life (WHOQOL-BREF), a shorter version of the widely used QOL ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.51790
更新日期:2009-03-01 00:00:00
abstract::The utilization of therapeutic drug monitoring (TDM) for serum digoxin and theophylline was assessed with respect to the indication, time of sample collection and contribution to patient care. A total of 585 serum drug level determinations of digoxin (275) and theophylline (328) were done in a four month period. Reaso...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.178
更新日期:1992-03-01 00:00:00
abstract::Pena-Shokeir phenotype is a unique pattern of lethal multiple congenital anomalies with variable expression. The history of a family in which two sibs conform to Pena-Shokeir phenotype is detailed and substantiates the criteria for definition of the phenotype. The addition of a peculiar ultrasound presentation in the ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.264
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Amaranthus pollen grains are known to be highly allergenic and a potential cause of respiratory allergic diseases. Nevertheless, data on the prevalence of Amaranthus pollen in the environment is limited and almost non-existent for Saudi Arabia. METHODS:We conducted an investigation to record the airborne in...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2007.259
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder which causes neonatal jaundice in most cases, and under certain conditions, can cause a spectrum of hemolytic manifestations. OBJECTIVE:To determine the local prevalence of G6PD deficiency in newborns. DESIGN:Cross-sectional. SETT...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.362
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Surprisingly, it is estimated that about half of type 2 diabetics remain undetected. The possible causes may be partly attributable to people with normal fasting plasma glucose (FPG) but abnormal postprandial hyperglycemia. We attempted to develop an effective predictive model by using the metabolic syndrome...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2007.339
更新日期:2007-09-01 00:00:00
abstract::A review of 100 referral letters and reports randomly selected from two health centers in Riyadh identified that the main reason for referral was general therapeutic advice (43.2%), general diagnostic evaluation (24.8%), and routine specialist examination (11.7%). Of the total referrals, 82.1% were seen within a week ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.658
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Hepatitis B is a disease that is preventable with vaccination. Antibody levels after vaccination may be affected by suppression of the immune system due to cancer therapy. Children with cancer have a high risk of hepatitis B virus (HBV) infection. We aimed to assess the pretreatment immunizati...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.87091
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Each of the metabolic syndrome (MetS) components (central obesity, hypertriglyceridemia, hypertension, low high-density lipoprotein cholesterol, and insulin resistance) may arise from an underlying disease or factors such as hormonal or pharmacological factors. These components arising seconda...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.566
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Seating position in motor vehicle collisions (MVC) plays a major role in determining the injury pattern in mainly restrained children. However, compliance with child seating and restraint laws is still suboptimal. The role of seating position in predicting injury patterns among unrestrained ch...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.502
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To compare the complications and outcome after ileal pouch-anal anastomosis (IPAA) for mucosal ulcerative colitis (MUC) and familial adenomatous polyposis (FAP). DESIGN AND SETTINGS:This is a retrospective study. The study was conducted at a single tertiary referral center. METHODS:All patie...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.268
更新日期:2013-05-01 00:00:00
abstract::This retrospective study was performed to compare the pregnancy rates (PR) in patients treated with either in vitro fertilization (IVF) or controlled ovarian superstimulation (COS) and intrauterine insemination (IUI) in patients with unexplained infertility. In Group A, 77 females underwent 125 treatment cycles of IVF...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1995.462
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Benign prostatic hyperplasia (BPH) develops in elderly males when serum androgens are relatively lower than in healthy younger males, but it is not well understood whether and how sex steroids are altered in prostatic hyperplasia. It is also uncertain whether there is any change in sex steroid levels in male...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2008.174
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Road traffic injuries (RTIs) are the third leading cause of death in Saudi Arabia. Because speed is a major risk factor for severe crash-related injuries, a camera ticketing system was implemented countrywide in mid-2010 by the traffic police in an effort to improve traffic safety. There are no published stu...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.1
更新日期:2017-01-01 00:00:00
abstract::A retrospective study of 22 adult patients with dermatomyositis (DM) or polymyositis (PM) was performed. Male to female ratio was 1:2.7. Mean age of onset was 37.3 +/- (16.3) and symptoms were present for a mean of 11.2 +/- 14.6 months before diagnosis. Primary polymyositis was diagnosed in 11 (50%), primary dermatomy...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.525
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Predictive equations for estimating glomerular filtration rate (GFR) in different clinical conditions should be validated by comparing with the measurement of GFR using inulin clearance, a highly accurate measure of GFR. OBJECTIVES:Our aim was to validate the Chronic Kidney Disease-Epidemiology Collaboratio...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2016.28.3.1715
更新日期:2016-03-01 00:00:00
abstract::Over a seven-year period, 1093 cases of tumors of soft-tissue origin were recorded by the Pathology Department of King Fahd Hospital of the University, Al-Khobar. Of these, detailed histopathological analysis was performed on 685 tumors of adipose-tissue origin removed from 640 patients. Of the 45 multiple tumors, 31 ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.28
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Celiac disease (CD) is an immune-mediated enteropathy, induced by gluten in genetically susceptible individuals. The objective of this study was to describe the clinical pattern of CD in children from the western region of Saudi Arabia. DESIGN AND SETTING:Retrospective, hospital-based. PATIE...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.75779
更新日期:2011-01-01 00:00:00
abstract::The authors reviewed six cases of multiple brain abscesses that were treated at King Khalid University Hospital (KKUH) over an eight year period. This represented 22% of the total brain abscesses treated during the same period. The series is unusual in that the infective pathogens were fungi (Fonsecaea pedrosoi) in tw...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.30
更新日期:1994-01-01 00:00:00
abstract::Recent reports indicate that nalidixic acid susceptibility correlates well with the clinical outcome of patients with Salmonella Typhi infection treated with quinolones. We report a case of enteric fever caused by S Typhi in which the isolate was resistant to nalidixic acid, but showed in vitro susceptibility to cipro...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.65267
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Despite its relatively low incidence in Saudi Arabia, breast cancer has been the most common cancer among Saudi females for the past 12 consecutive years. The objective of this study was to report the results of the first national public breast cancer screening program in Saudi Arabia. METHOD...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.67078
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Brain natriuretic peptide (BNP) has a role in the regulation of body fluid volume and blood pressure (BP). BNP remains within a normal range during spinal anaesthesia (SA) in patients undergoing cesarean delivery. However, the effect of BNP on changes in BP during the perioperative period has ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2015.248
更新日期:2015-05-01 00:00:00
abstract::The objective of this case control study was no identify the possible associated risk factors of mild mental retardation in children. Sixty-nine parents of mildly mentally retarded (MR group) male children and a similar number of matched parents of normal male children (control) were interviewed using a questionnaire....
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.355
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Improving the reproductive health of females has be.come the focus of the developmental efforts of many nations. OBJECTIVES:To identify the reproductive health style of married females, and to determine the prevalence and predictors of circumcision among girls aged less than or equal 18 years in Hali semi-u...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.81
更新日期:2018-03-01 00:00:00
abstract::Ependymomas outside the confines of the cranium and spinal cord are rare. The occurrence of these tumors in an extradural, sacrococcygeal, or subcutaneous location may prove challenging, particularly in the absence of any obvious central nervous system connection. The origin of these tumors from sub.cutaneous sacrococ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2014.262
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The results of the National Nutrition Survey of the people of the Kingdom of Saudi Arabia showed that the prevalence of arterial hypertension (BP >/= 160/95 mmHg) among the adult population is 5.3% and 7.3% for systolic and diastolic hypertension, respectively. The objective of this study, which is part of t...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1998.401
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Toxoplasmosis, caused by Toxoplasma gondii, is diagnosed mainly by serological methods that are hindered by insufficient sensitivity. When it fails, it becomes necessary to rely on either direct detection of the parasite or DNA detection by polymerase chain reaction (PCR). We aimed to establis...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.14.7.1200
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:This report describes our experience with 15 consecutive emergency cervical cerclages performed at Al Yamamah Hospital. PATIENTS AND METHODS:Between February 1994 and February 1997, 15 women with singleton pregnancies between 18 and 26 weeksâ gestation, with a cervical dilatation between 3 and 10 cm and wit...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1999.23
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In Saudi Arabia (SA), injuries are the second leading cause of death; however, little is known about their frequencies and outcomes. Trauma registries play a major role in measuring the burden on population health. This study aims to describe the population of the only hospital-based trauma re...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2014.291
更新日期:2014-07-01 00:00:00
abstract::A prospective study of 109 patients with non-classical symptoms of appendicitis using the standard ultrasound (US) machine and plain abdominal x-rays demonstrated that US was superior to plain x-ray with a sensitivitiy, specificity and overall accuracy of 89%, 96% and 91%, respectively as compared with plain x-ray wit...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.41
更新日期:1993-01-01 00:00:00