Abstract:
:Neonatal diabetes mellitus is considered a rare disease that is diagnosed in the first six months of life, and can be either transient or permanent. Recent advances in molecular genetics have shown that activating mutations in KCNJ11 (the gene that encodes for the Kir6.2 subunit of the K ATP potassium channel of the pancreatic beta-cell) is a common cause of permanent neonatal diabetes mellitus. Patients with mutations in this gene may respond to oral sulfonylureas. We describe a 3-year-old girl with permanent neonatal diabetes mellitus with a mutation in the KCNJ11 gene (R201H), who was successfully transferred from subcutaneous insulin to oral glibenclamide, with a marked improvement in glycemic control. This is the first successful switch from insulin to oral sulfonylurea in a patient with R201H mutation, in the Arabian Gulf.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Al-Mahdi M,Al Mutair A,Al Balwi M,Hussain Kdoi
10.4103/0256-4947.60526subject
Has Abstractpub_date
2010-03-01 00:00:00pages
162-4issue
2eissn
0256-4947issn
0975-4466pii
AnnSaudiMed_2010_30_2_162_60526journal_volume
30pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:Vaccination during periods of lymphopenia may facilitate immune responses to weak self-antigens and enhance antitumor immunity. The objective of this study was to determine the effectiveness of tumor vaccine immunotherapy combined with immune reconstruction using tumor-bearing host immune cells...
journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.2014.122
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.425
更新日期:2017-11-01 00:00:00
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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更新日期:2020-11-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2000.214
更新日期:2000-05-01 00:00:00
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2014.427
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Studies about stroke in Saudi Arabia are limited. This retrospective study aims to determine the clinical characteristics of Saudi patients with heart failure (HF) with and without subsequent stroke, and also to find out whether gender differences exist in the presentation of HF patients who h...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Annals of Saudi medicine
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更新日期:2011-05-01 00:00:00
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.467
更新日期:1994-11-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2003.367
更新日期:2003-11-01 00:00:00
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.246
更新日期:1993-05-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2005.124
更新日期:2005-03-01 00:00:00