Successful transfer from insulin to oral sulfonylurea in a 3-year-old girl with a mutation in the KCNJ11 gene.

Abstract:

:Neonatal diabetes mellitus is considered a rare disease that is diagnosed in the first six months of life, and can be either transient or permanent. Recent advances in molecular genetics have shown that activating mutations in KCNJ11 (the gene that encodes for the Kir6.2 subunit of the K ATP potassium channel of the pancreatic beta-cell) is a common cause of permanent neonatal diabetes mellitus. Patients with mutations in this gene may respond to oral sulfonylureas. We describe a 3-year-old girl with permanent neonatal diabetes mellitus with a mutation in the KCNJ11 gene (R201H), who was successfully transferred from subcutaneous insulin to oral glibenclamide, with a marked improvement in glycemic control. This is the first successful switch from insulin to oral sulfonylurea in a patient with R201H mutation, in the Arabian Gulf.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Al-Mahdi M,Al Mutair A,Al Balwi M,Hussain K

doi

10.4103/0256-4947.60526

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

162-4

issue

2

eissn

0256-4947

issn

0975-4466

pii

AnnSaudiMed_2010_30_2_162_60526

journal_volume

30

pub_type

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