Omalizumab therapy in three patients with chronic autoimmune urticaria.

Abstract:

:Chronic urticaria is a common skin disease. In about 45% of patients the cause is an autoantibody directed at the α-subunit of the high-affinity IgE receptor (chronic autoimmune urticaria; CAU). Omalizumab is a monoclonal anti-IgE antibody that has a proven role in the treatment of various allergic diseases. We gave omalizumab once every month for 16 weeks to three patients that were refractory to standard treatment, including high doses of antihistamines, leukotriene receptor antagonist, and corticosteroid. There was dramatic improvement in the primary efficacy variable--the change in mean urticaria activity score (UAS) from baseline (i.e., the average over the first 4-week period before omalizumab) to the final 4-week period of omalizumab treatment. There was improvement in the secondary efficacy variables, which included change from baseline in interference with sleep, interference with daily activities, daily diary record of urticaria signs and symptoms based on a scoring system, and rescue medication use. These improvements persisted for 12 weeks after discontinuation of the drug. Omalizumab may have a role in treating refractory cases of CAU.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Al-Ahmad M

doi

10.4103/0256-4947.70567

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

478-81

issue

6

eissn

0256-4947

issn

0975-4466

pii

70567

journal_volume

30

pub_type

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