Abstract:
BACKGROUNDS AND OBJECTIVES:B-thalassemia major is one of the most frequent hematological genetic disorders, worldwide. Chemokines are the main components of the immune system and play fundamental roles in pathogenesis of inflammatory disorders. Therefore, the present study aimed to examine whether serum CXC chemokines are altered in b-thalassemia major patients. DESIGN AND SETTINGS:We enrolled 63 b-thalassemia patients and 80 controls in this cross-sectional study, which was performed during 2012-2013 in Kerman, Iran. METHODS:We enrolled 63 b-thalassemia patients and 80 controls in the present study. Patients were selected from referrals to Samenolhojaj clinic for thalassemia, Kerman, Iran. The circulating levels of CXCL1, CXCL9, CXCL10, and CXCL12 were detected by enzyme-linked immunosorbent assay in thalassemia patients and healthy controls immediately after blood collection. Data were analyzed by c2, t-test, and analysis of variance statistical methods and using SPSS, version 13 (SPSS Inc., Chicago, IL). RESULTS:The results of the study demonstrated a significant elevation of CXCL1, CXCL9, CXCL10, and CXCL12 in thalassemia patients than in control. These results also demonstrated that serum chemokine levels are related to transfusion duration and post-transfusion viral infections. CONCLUSION:According to the results obtained, it can probably be concluded that chemokines are also involved in the pathogenesis of b-thalassemia major and its clinical complications in addition to several other parameters.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Najmaddini H,Hassanshahi G,Ostadebrahimi H,Barkhordari H,Mashayekhi H,Nazari M,Moogooei M,Arababadi YS,Peighambari F,Karimabad MNdoi
10.5144/0256-4947.2014.122subject
Has Abstractpub_date
2014-03-01 00:00:00pages
122-7issue
2eissn
0256-4947issn
0975-4466journal_volume
34pub_type
杂志文章abstract:BACKGROUND:Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.425
更新日期:2017-11-01 00:00:00
abstract::Evidence of cardiovascular complications associated with the COVID-19 global pandemic continues to evolve. These include direct and indirect myocardial injury with subsequent acute myocardial ischemia, and cardiac arrhythmia. Some results from a limited number of trials of antiviral medications, along with chloroquine...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,评审
doi:10.5144/0256-4947.2020.365
更新日期:2020-09-01 00:00:00
abstract::Two cases of Strongyloides stercoralis hyperinfection are described. Both patients were expatriates from the Indian subcontinent, and reported the use of corticosteroids. The first patient presented with severe pulmonary disease that necessitated respiratory support, followed by acute abdomen and intestinal obstructio...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.55172
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Infection due to Coxiella burnetii (C burnetii), the causative agent of Q fever is rarely sought for in clinical practice. This study was performed to detect C burnetii infection in patients with pyrexia of undetermined cause (PUC). DESIGN AND SETTINGS:This is a prospective study conducted at...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.464
更新日期:2013-09-01 00:00:00
abstract::A prospective study of 109 patients with non-classical symptoms of appendicitis using the standard ultrasound (US) machine and plain abdominal x-rays demonstrated that US was superior to plain x-ray with a sensitivitiy, specificity and overall accuracy of 89%, 96% and 91%, respectively as compared with plain x-ray wit...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.41
更新日期:1993-01-01 00:00:00
abstract::Moraxella (Branhamella) catarrhalis is now recognized as an important cause of respiratory tract infections. Over a two year period, Moraxella (Branhamella) catarrhalis was isolated in pure culture from 3.4% of the sputums collected from patients with symptoms of acute respiratory tract infections. It was the third mo...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.562
更新日期:1992-11-01 00:00:00
abstract::This is the first population-based data in Saudi Arabia on the incidence of leukemias in the Eastern Region, as conducted by its regional tumor registry. Data on cancer were captured from all health facilities in the region in 1987-1988. Population census was derived from a survey. Data on cancer deaths were obtained ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1996.521
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:In children, steroid-resistant nephritic syndrome due to focal segmental glomerulosclerosis (FSGS) is frequently a progressive condition resulting in end-stage renal disease (ESRD). We report the response of 15 patients with steroid resistant FSGS to treatment with intravenous pulse cyclophosphamide (IVCP) a...
journal_title:Annals of Saudi medicine
pub_type: 临床试验,杂志文章
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更新日期:2004-01-01 00:00:00
abstract::A treatable and preventable disorder, congenital hypothyroidism (CH) is still a common cause of mental retardation. A 17-year-old Saudi boy with CH due to an ectopic thyroid gland was diagnosed by the neonatal screening program.Thyroxine replacement therapy was started for one month when the family chose to discontinu...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.26.5.1137
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abstract::This study looks at the incidence of head and neck cancer in the Southwest Region of the Kingdom of Saudi Arabia (Asir Region). There were a total of 204 newly diagnosed patients seen at Asir Central Hospital between 1987 and 1992; 113 males and 91 females. All were Saudi patients. Frequency at various sites with refe...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.383
更新日期:1994-09-01 00:00:00
abstract::Recent reports indicate that nalidixic acid susceptibility correlates well with the clinical outcome of patients with Salmonella Typhi infection treated with quinolones. We report a case of enteric fever caused by S Typhi in which the isolate was resistant to nalidixic acid, but showed in vitro susceptibility to cipro...
journal_title:Annals of Saudi medicine
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doi:10.4103/0256-4947.65267
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abstract:BACKGROUND:During the Eid al-Adha ("Sacrifice Feast") religious holiday in Muslim communities animal sacrifices are made over a period of 3 days every year. OBJECTIVES:The aim of this study was to determine the type of sacrifice-related injuries, the characteristics of patients, treatments for injuries, and relationsh...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2016.139
更新日期:2016-03-01 00:00:00
abstract::The ever-increasing incidence of diabetes mellitus is a cause for growing public health concern in both developed and developing countries. In this study, we aim to explore the special demographic and clinical features of diabetes, as seen in a large sample of Yemeni patients, and to compare these features with those ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1997.402
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:The prevalence of overweight/obesity in children in Saudi Arabia is among the highest in the world. The prevalence of dental caries is also high in Saudi children. Studies on the relationship between caries and obesity in Saudi adolescents are lacking. OBJECTIVES:To study the prevalence of overweight/obesit...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.114
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Brain natriuretic peptide (BNP) has a role in the regulation of body fluid volume and blood pressure (BP). BNP remains within a normal range during spinal anaesthesia (SA) in patients undergoing cesarean delivery. However, the effect of BNP on changes in BP during the perioperative period has ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2015.248
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The differentiation of extramedullary myelogenous leukemia/granulocytic sarcoma (GS) from malignant lymphoma can sometimes be difficult. In the current study, we explored the value of CD34, myeloperoxidase and nonspecific esterase (Leder) stains in differentiating GS from lymphomas. MATERIALS AND METHODS:Fi...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2001.287
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Coronary artery calcification (CAC) is indicated by calcium deposits in the coronary artery wall. Calcification is a component of atherosclerosis and coronary artery disease. Currently, there are no data on calcification in Saudi women at high risk of coronary artery disease. The aim of this st...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2015.298
更新日期:2015-07-01 00:00:00
abstract::Forty cases of cerebral abscesses were studied prospectively to establish the microbial agents implicated in these cases. Chronic otitis media (14 patients, 35%), congenital heart disease (five patients, 12.5%),a and meningitis (five patients, 12.5%) were among the important predisposing factors. Streptococcus (14 pat...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.424
更新日期:1991-07-01 00:00:00
abstract::The authors reviewed six cases of multiple brain abscesses that were treated at King Khalid University Hospital (KKUH) over an eight year period. This represented 22% of the total brain abscesses treated during the same period. The series is unusual in that the infective pathogens were fungi (Fonsecaea pedrosoi) in tw...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.30
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abstract:BACKGROUND:Total laboratory automation (TLA) is a relatively new way of improving the management of high volume clinical laboratories. TLA may reduce staff, reduce operating costs, decrease testing time and provide enhanced process control. OBJECTIVES:Establish a cost efficient TLA that is less labor intensive, improv...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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abstract:BACKGROUND:Improving the reproductive health of females has be.come the focus of the developmental efforts of many nations. OBJECTIVES:To identify the reproductive health style of married females, and to determine the prevalence and predictors of circumcision among girls aged less than or equal 18 years in Hali semi-u...
journal_title:Annals of Saudi medicine
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abstract::Placental steroid sulphatase deficiency (SSD) is an X-linked inborn error of metabolism. Congenital X-linked ichthyosis (XLI) is a genetic disorder of keratinisation caused by steroid sulphatase (STS) deficiency, which results in a scaling skin condition in male infants shortly after birth. It may be associated with f...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.445
更新日期:2018-11-01 00:00:00
abstract::There were no studies on the different stages of diabetic nephropathy in Saudi Arabia, particularly the earliest stages. We have therefore investigated the frequency of occurrence of varying degrees of proteinuria including microalbuminuria in noninsulin-dependent diabetes mellitus (NIDDM) Saudi patients as well as th...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1995.120
更新日期:1995-03-01 00:00:00
abstract::Two cases of orf occuring in one family are reported. The patients developed characteristic skin lesions one week after sustaining cuts while slaughtering a sheep. The diagnosis of orf was confirmed by electron microscopy which revealed numerous large oval virus particle characteristics of parapox virus. This we belie...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1986.49
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The propensity of Ascaris lumbricoides to wander leads to varied surgical complications in the abdomen. Wandering A lumbricoides may sometimes reach the vermiform appendix and its presence there may remain silent or incite pathology. Our aim was to study ascariadial appendicitis. METHODS:Over a period of 3 ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.59380
更新日期:2010-01-01 00:00:00
abstract::Spontaneous spinal epidural hematoma is an uncommon cause of cord compression in children, especially in infants. An 8-month-old infant was admitted to our hospital for a 40-day history of paraparesis in the lower extremities. This rapidly progressed to paraparesis with an inability to move the lower extremities. MRI ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.75586
更新日期:2011-05-01 00:00:00
abstract::Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease--a widely prevalent but often silent condition. Obesity carries elevated risks of...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,评审
doi:10.5144/0256-4947.2006.288
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Different types of modified ultrafiltration (MUF) systems evaluated showed that none of the MUF techniques adhered to the normal venous to arterial blood flow dynamics. This study compared a conventional arteriovenous modified ultrafiltration (AVMUF) system to a custom- designed venoarterial m...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,随机对照试验
doi:10.5144/0256-4947.2014.18
更新日期:2014-01-01 00:00:00
abstract::The Cosman-Roberts-Wells (CRW-3) scanner independent stereotactic system is a recent arc-radius design developed from the Brown-Roberts-Wells system. The results of 74 supratentorial non-basal tumor suspect cases treated with this second generation computed tomography (CT) guided stereotactic apparatus are presented. ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.507
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Although the rate of multiple drug resistance is high, there is no published data on the transmission rate of drug-resistant strains of Mycobacterium tuberculosis in the Aegean region of western Turkey that are based on molecular methods. METHODS:IS6110 and pTBN12 restriction fragment length polymorphism (R...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2004.102
更新日期:2004-03-01 00:00:00