Epidemiology of sickle cell disease in Saudi Arabia.

Abstract:

:Sickle cell disease (SCD) is an autosomal recessive disorder characterized by production of abnormal hemoglobin S and is associated with high morbidity and mortality. Information about the prevalence of SCD in Saudi Arabia is patchy and probably underestimated, but studies have reported that SCD is a relatively common genetic disorder in this part of the world. The prevalence of SCD in Saudi Arabia varies significantly in different parts of the country, with the highest prevalence is in the Eastern province, followed by the southwestern provinces. The reported prevalence for sickle-cell trait ranges from 2% to 27%, and up to 2.6% will have SCD in some areas. Clinical and hematological variability exists in SCD in Saudi Arabia with two major phenotypes: a mild phenotype and a severe phenotype. Further studies on the prevalence, molecular and clinical epidemiology of SCD may help predict disease severity and risk stratification of patients to determine whether to receive early intensive care or continued symptomatic care.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Jastaniah W

doi

10.4103/0256-4947.81540

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

289-93

issue

3

eissn

0256-4947

issn

0975-4466

pii

AnnSaudiMed_2011_31_3_289_81540

journal_volume

31

pub_type

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