Abstract:
BACKGROUND AND OBJECTIVES:Genomic scan analyses have suggested that the chemokine receptor cluster (CCR2, CCR3, CCR5 <300 kb span) on the short arm of chromosome 3 may contribute to susceptibility to HIV-1 infection and to the expression of a number of inflammatory diseases. Two single-nucleotide polymorphisms (SNP) and a deletion in these chemokine receptors have also been found in case-control studies to be associated with susceptibility for asthma and related phenotypes. We extended these case-control studies by establishing whether these polymorphisms were in linkage and linkage disequilibrium with asthma and related phenotypes using linkage and haplotype analyses. METHODS:We genotyped 154 nuclear families identified through two child probands with physician-diagnosed asthma (453 unrelated individuals) including 303 unrelated parents and 150 unrelated children. Atopy was defined as a positive skin prick test (SPT 3 mm) to a panel of common inhaled allergens. RESULTS:From a panel of ten known SNPs, only three polymorphisms: -G190A in CCR2, -T51C in CCR3, and a 32 bp deletion in CCR5 were found to occur at clinically relevant frequencies. All 154 families were used for haplotype analysis but only 12 nuclear families were eligible for linkage analysis. Both analyses confirmed that the mutations were in linkage with asthma, but not with atopy. CONCLUSION:The chemokine receptor genes on 3p21.3 are significantly plausible candidate genes that can influence the expression of asthma. The previous association of the CCR532 deletion with protection from childhood asthma appears to be explained by linkage disequilibrium with the -G190A mutation in the CCR2 receptor gene.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Al-Abdulhadi SA,Al-Rabia MWdoi
10.4103/0256-4947.60516subject
Has Abstractpub_date
2010-03-01 00:00:00pages
115-22issue
2eissn
0256-4947issn
0975-4466pii
AnnSaudiMed_2010_30_2_115_60516journal_volume
30pub_type
杂志文章abstract::Enterococci with high level of aminoglycosides resistance are being reported from different parts of the world with increasing frequency. Treatment of infections caused by such isolates is associated with a high incidence of failure or relapse. This is attributed to the loss of the synergetic effect of aminoglycosides...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.290
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Experience with alteplase in pediatric patients is limited and recommendations are extrapolated from adult data. Comprehensive guidelines on the management of thromboembolic events in this group are lacking. We assessed the efficacy and safety of alteplase (recombinant tissue plasminogen activ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.62840
更新日期:2010-05-01 00:00:00
abstract::We have presented an interesting case of an unexpected orbital tumor in a 5-month-old female healthy baby who presented initially with a 1-week history of acute left proptosis, swollen eyelid, conjunctival chemosis and exposure keratopathy. She was treated with intravenous antibiotics without any improvement and was r...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.623
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Transesophageal echocardiography (TEE), being a displeasing intervention, usually entails sedation. We aimed to compare the effects of hypnosis and midazolam for sedation in TEE. DESIGN AND SETTINGS:A prospective single-blinded study conducted on patients scheduled for TEE between April 2011 and July 2011 a...
journal_title:Annals of Saudi medicine
pub_type: 临床试验,杂志文章
doi:10.5144/0256-4947.2015.58
更新日期:2015-01-01 00:00:00
abstract::The objective of this prospective, randomized study was to compare the effectiveness of fiberoptic, conventional and a combination phototherapy in decreasing bilirubin concentrations in neonatal nonhemolytic hyperbilirubinemia. Forty-six infants who were 36 weeks' gestation and more were randomly assigned to fiberopti...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1996.633
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Benign prostatic hyperplasia (BPH) develops in elderly males when serum androgens are relatively lower than in healthy younger males, but it is not well understood whether and how sex steroids are altered in prostatic hyperplasia. It is also uncertain whether there is any change in sex steroid levels in male...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2008.174
更新日期:2008-05-01 00:00:00
abstract::Submucosal diathermy of the inferior turbinate (SMDIT) is a generally safe procedure to control inferior turbinate hypertrophy. We present a case of a cerebrospinal fluid (CSF) leak at the craniocervical junction after SMDIT done in another institution. A 27-year-old man presented 3 weeks after undergoing SMDIT with s...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.143
更新日期:2018-03-01 00:00:00
abstract::The aim of this study was to evaluate the sequelae of menopause and how this can be managed in a primary health care setting. Between June 1992 and June 1994, 261 postmenopausal females who attended the menopause clinic at the Kuwait Maternity Hospital were evaluated clinically and with laboratory investigations; mamm...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::Forty cases of cerebral abscesses were studied prospectively to establish the microbial agents implicated in these cases. Chronic otitis media (14 patients, 35%), congenital heart disease (five patients, 12.5%),a and meningitis (five patients, 12.5%) were among the important predisposing factors. Streptococcus (14 pat...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.424
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Autosomal recessive primary microcephaly (MCPH) is a clinically and genetically heterogeneous disorder. Patients with MCPH exhibit reduced occipito-frontal head circumference and non-progressive intellectual disability. To date, 17 genes have been known as an underlying cause of MCPH in humans. ASPM (abnorma...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2016.391
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Each of the metabolic syndrome (MetS) components (central obesity, hypertriglyceridemia, hypertension, low high-density lipoprotein cholesterol, and insulin resistance) may arise from an underlying disease or factors such as hormonal or pharmacological factors. These components arising seconda...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.566
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Vaccination during periods of lymphopenia may facilitate immune responses to weak self-antigens and enhance antitumor immunity. The objective of this study was to determine the effectiveness of tumor vaccine immunotherapy combined with immune reconstruction using tumor-bearing host immune cells...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.162
更新日期:2012-03-01 00:00:00
abstract:AIMS:Type 2 diabetes mellitus (T2DM) is characterized by both decreased insulin sensitivity and impaired insulin secretion. The 2 phases of insulin secretion are the first-phase insulin secretion (1st ISEC) and the second-phase insulin secretion. In this study, we tried to build clinical-metabolic models to predict the...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2015.138
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The illegal use of melamine in powdered baby formula resulted in a widespread outbreak of melamine-associated pediatric urolithiasis and kidney damage in China in 2008. We conducted this study because more needs to be known about the long-term effects of melamine-associated urolithiasis and kidney damage. O...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2016.252
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Adult females have significantly more leptin than males. We investigated the effect of fetal sex on levels of leptin and other pregnancy hormones (progesterone, estradiol, FSH, LH and beta hCG) in pregnant females during different stages of pregnancy. PATIENTS AND METHODS:Serum leptin levels in pregnant fem...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2005.124
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:The association of type 2 diabetes mellitus and hypertension is so high that it cannot be explained on the basis of diabetic nephropathy. This phenomenon has been attributed to a condition known as metabolic syndrome. Depression may be another aspect of metabolic syndrome. PATIENTS AND METHODS:We conducted ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2003.254
更新日期:2003-09-01 00:00:00
abstract::Five cases of enteric fever due to multi-resistant Salmonella typhi are reported. Four of these patients most probably contracted the disease in India and the fifth in Egypt. All of them were successfully treated either with ceftriaxone or ciprofloxacin. ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.246
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:In children, steroid-resistant nephritic syndrome due to focal segmental glomerulosclerosis (FSGS) is frequently a progressive condition resulting in end-stage renal disease (ESRD). We report the response of 15 patients with steroid resistant FSGS to treatment with intravenous pulse cyclophosphamide (IVCP) a...
journal_title:Annals of Saudi medicine
pub_type: 临床试验,杂志文章
doi:10.5144/0256-4947.2004.27
更新日期:2004-01-01 00:00:00
abstract::Eighteen cases of traumatic fracture dislocation were managed surgically using a technique which involved an anterior cervical approach followed by discectomy, bone graft, and insertion of a metal plate. The patients were mobilized early to prevent the usual complications of bedsores, deep vein thrombosis, pulmonary e...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.189
更新日期:1991-03-01 00:00:00
abstract::This retrospective study was performed to compare the pregnancy rates (PR) in patients treated with either in vitro fertilization (IVF) or controlled ovarian superstimulation (COS) and intrauterine insemination (IUI) in patients with unexplained infertility. In Group A, 77 females underwent 125 treatment cycles of IVF...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1995.462
更新日期:1995-09-01 00:00:00
abstract::Myocardial perfusion single photon emission-computed tomography (MPS) has been one of the most important and common non-invasive diagnostic cardiac test. Gated MPS provides simultaneous assessment of myocardial perfusion and function with only one study. With appropriate attention to the MPS techniques, appropriate cl...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,评审
doi:10.4103/0256-4947.87101
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The clinical features of acute myeloblastic leukemia (AML) and its response to therapy in adult patients in Saudi Arabia are not well defined, as only scanty data has been available. This situation will likely continue unless experience with AML is reported from different institutions in the Kingdom. PATIEN...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1998.221
更新日期:1998-05-01 00:00:00
abstract::A wide variety of long-term complications may be noted following conventional cancer treatment. These include overwhelming postsplenectomy sepsis syndrome, central and peripheral nervous system toxicity, cardiovascular complications, chronic liver damage, and secondary malignancy. Follow-up monitoring usually incorpor...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1997.622
更新日期:1997-11-01 00:00:00
abstract::Although cataract surgery is increasingly being performed under local anesthesia in many centers, general anesthesia is preferred for cataract surgery at the King Fahd Hospital of the University (KFHU), Al-Khobar. Ninety two patients who had cataract extraction under general anesthesia at KFHU between October 1988 and...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.13
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Amaranthus pollen grains are known to be highly allergenic and a potential cause of respiratory allergic diseases. Nevertheless, data on the prevalence of Amaranthus pollen in the environment is limited and almost non-existent for Saudi Arabia. METHODS:We conducted an investigation to record the airborne in...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2007.259
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Esophageal atresia (EA), with or without tracheoesophageal fistula (TOF) is one of the most correctable fetal anomalies if diagnosed antenatally by serial ultrasound. We retrospectively evaluated antenatal diagnoses by ultrasound of EA with or without TOF at our institution in Saudi Arabia. PATIENTS AND MET...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2003.132
更新日期:2003-05-01 00:00:00
abstract::Three hundred and seventy-six consecutive antinuclear antibody-positive sera were tested for anti-ds DNA antibody by using three commercial kits which use 125 I recombinant DNA (radioimmunoassay), highly purified calf thymus DNA (enzyme linked immunosorbent assay) and Crithidia lucilliae (immunofluorescence assay) as ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1995.327
更新日期:1995-07-01 00:00:00
abstract::Neonatal diabetes mellitus is considered a rare disease that is diagnosed in the first six months of life, and can be either transient or permanent. Recent advances in molecular genetics have shown that activating mutations in KCNJ11 (the gene that encodes for the Kir6.2 subunit of the K ATP potassium channel of the p...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.60526
更新日期:2010-03-01 00:00:00
abstract::Two cases of Strongyloides stercoralis hyperinfection are described. Both patients were expatriates from the Indian subcontinent, and reported the use of corticosteroids. The first patient presented with severe pulmonary disease that necessitated respiratory support, followed by acute abdomen and intestinal obstructio...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.55172
更新日期:2009-09-01 00:00:00
abstract::The objective of this case control study was no identify the possible associated risk factors of mild mental retardation in children. Sixty-nine parents of mildly mentally retarded (MR group) male children and a similar number of matched parents of normal male children (control) were interviewed using a questionnaire....
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.355
更新日期:1993-07-01 00:00:00