Clinical experience with alteplase in the management of intracardiac and major cardiac vessels thrombosis in pediatrics: a case series.

Abstract:

BACKGROUND AND OBJECTIVES:Experience with alteplase in pediatric patients is limited and recommendations are extrapolated from adult data. Comprehensive guidelines on the management of thromboembolic events in this group are lacking. We assessed the efficacy and safety of alteplase (recombinant tissue plasminogen activator) in the management of intracardiac and major cardiac vessel thrombosis in pediatric patients. METHODS:All pediatric patients, 14 years of age and younger, with intracardiac or major cardiac vessel thrombus who were treated with alteplase from 1997 to 2004 at our tertiary care institute were identified through the pharmacy database. Patient data were retrospectively evaluated for the efficacy and safety of altepase. RESULTS:Five cases were eligible out of nineteen who received alteplase. Patient ages ranged from 40 days to 13 years. The initial dose of alteplase ranged from 0.3 to 0.6 mg/kg followed by a continuous infusion in three patients with a dosage range between 0.05 and 0.5 mg/kg/hr, while intermittent infusion was used in the other two patients. The duration of therapy ranged from 2 to 4 days. By the end of the treatment, two patients had complete resolution of thrombus and one had partial resolution. Two patients failed to respond and had "old" thrombus. Major bleeding events were reported in three patients. The rest had minor bleeding events. CONCLUSION:Alteplase may effectively dissolve intracardiac thrombi, particularly when freshly formed. Continuous infusion for a long duration appears to be associated with an increased risk of major bleeding. Optimal dose and duration of infusion are still unknown.

journal_name

Ann Saudi Med

journal_title

Annals of Saudi medicine

authors

Al-Jazairi AS,Al-Gain RA,Bulbul ZR,Cherfan AJ

doi

10.4103/0256-4947.62840

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

227-32

issue

3

eissn

0256-4947

issn

0975-4466

pii

AnnSaudiMed_2010_30_3_227_62840

journal_volume

30

pub_type

杂志文章
  • Mature teratoma presenting as orbital cellulitis in a 5-month-old baby.

    abstract::We have presented an interesting case of an unexpected orbital tumor in a 5-month-old female healthy baby who presented initially with a 1-week history of acute left proptosis, swollen eyelid, conjunctival chemosis and exposure keratopathy. She was treated with intravenous antibiotics without any improvement and was r...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.623

    authors: Alkatan HM,Chaudhry I,Alayoubi A

    更新日期:2013-11-01 00:00:00

  • Postpartum hepatotoxicity due to herbal medicine Teucrium polium.

    abstract::The hepatotoxicity cases due to herbal medical products have been increased in recent years. Teucrium polium (TP) (mountain germander) is one of the most popular species of the Lamiaceae family and is commonly used for increasing breast milk formation and for relieving gastrointestinal complaints in the last months of...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2014.541

    authors: Dag M,Özturk Z,Aydnl M,Koruk I,Kadayfç A

    更新日期:2014-11-01 00:00:00

  • Emerging global epidemic of obesity: the renal perspective.

    abstract::Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease--a widely prevalent but often silent condition. Obesity carries elevated risks of...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章,评审

    doi:10.5144/0256-4947.2006.288

    authors: Saxena AK

    更新日期:2006-07-01 00:00:00

  • Assessment of hepatitis B immunization status after antineoplastic therapy in children with cancer.

    abstract:BACKGROUND AND OBJECTIVES:Hepatitis B is a disease that is preventable with vaccination. Antibody levels after vaccination may be affected by suppression of the immune system due to cancer therapy. Children with cancer have a high risk of hepatitis B virus (HBV) infection. We aimed to assess the pretreatment immunizati...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.4103/0256-4947.87091

    authors: Karaman S,Vural S,Yildirmak Y,Urganci N,Usta M

    更新日期:2011-11-01 00:00:00

  • The monitoring of potential long-term comlications in treated adult cancer patients.

    abstract::A wide variety of long-term complications may be noted following conventional cancer treatment. These include overwhelming postsplenectomy sepsis syndrome, central and peripheral nervous system toxicity, cardiovascular complications, chronic liver damage, and secondary malignancy. Follow-up monitoring usually incorpor...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1997.622

    authors: Brigden ML

    更新日期:1997-11-01 00:00:00

  • Patients admitted to emergency units with injuries related to the four Hajj-associated annual animal sacrifice feasts from 2010 to 2013.

    abstract:BACKGROUND:During the Eid al-Adha ("Sacrifice Feast") religious holiday in Muslim communities animal sacrifices are made over a period of 3 days every year. OBJECTIVES:The aim of this study was to determine the type of sacrifice-related injuries, the characteristics of patients, treatments for injuries, and relationsh...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2016.139

    authors: Basturk M,Katirci Y,Ocak T,Yurdakul MS,Duran A,Baspinar I

    更新日期:2016-03-01 00:00:00

  • Gender differences in the clinical characteristics of Saudi heart failure patients with subsequent stroke.

    abstract:BACKGROUND AND OBJECTIVES:Studies about stroke in Saudi Arabia are limited. This retrospective study aims to determine the clinical characteristics of Saudi patients with heart failure (HF) with and without subsequent stroke, and also to find out whether gender differences exist in the presentation of HF patients who h...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.387

    authors: Alqahtani M,AlKhtaami A,AlGobain M,Aljohani N,Bin SA,AlShalati F,Alanazi T

    更新日期:2013-07-01 00:00:00

  • Coexistence of chronic lymphocytic leukemia and polycythemia vera: a case report and review of the literature.

    abstract::Polycythemia vera is a Philadelphia chromosome-negative myeloproliferative neoplasm. Chronic lymphocytic leukemia is a monoclonal expansion of a CD5+ CD19+ B lymphocytes. Chronic myeloproliferative neoplasms may coexist with indolent B-cell malignant lymphomas of various types. The association of chronic lymphocytic l...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章,评审

    doi:10.5144/0256-4947.2016.364

    authors: Korkmaz S,Kulakoglu S,Gorkem H,Aygun B,Cetinkaya A

    更新日期:2016-09-01 00:00:00

  • Prevalence of harassment and discrimination among residents in three training hospitals in Saudi Arabia.

    abstract:BACKGROUND AND OBJECTIVES:Multiple surveys of medical residents have shown a high incidence of harassment and discrimination in academic health centers. Harassment has a negative effects on residents' health and on their ability to function. No previous study has documented the prevalence of harassment and discriminati...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章,多中心研究

    doi:10.5144/0256-4947.2013.134

    authors: Fnais N,al-Nasser M,Zamakhshary M,Abuznadah W,Dhukair SA,Saadeh M,Al-Qarni A,Bokhari B,Alshaeri T,Aboalsamh N,Binahmed A

    更新日期:2013-03-01 00:00:00

  • Prevalence of antibodies to hepatitis C virus in Saudi patients with chronic liver disease.

    abstract::The prevalence of antibodies to hepatitis C virus (anti-HCV) has been measured in 113 Saudi patients with chronic liver diseases. Twenty-five percent of 20 patients with hepatocellular carcinoma (HCC) were positive for anti-HCV and 29.7% of 38 patients with cirrhosis and 27.3% of 33 patients with liver fibrosis, respe...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1991.497

    authors: Fakunle YM,Al-Mofarreh M,El-Drees AZ,El-Karamany WM,Ezzat HO,Ballesteros MN,Khawaji MZ

    更新日期:1991-09-01 00:00:00

  • Utilization of digoxin and theophylline assays in the eastern province.

    abstract::The utilization of therapeutic drug monitoring (TDM) for serum digoxin and theophylline was assessed with respect to the indication, time of sample collection and contribution to patient care. A total of 585 serum drug level determinations of digoxin (275) and theophylline (328) were done in a four month period. Reaso...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1992.178

    authors: Al-Ghamdi MS,Eferakeya A,Al-Sowayan S

    更新日期:1992-03-01 00:00:00

  • Steroid therapy for post-tonsillectomy symptoms in adults: a randomized, placebo-controlled study.

    abstract:BACKGROUND:Post-operative morbidity following tonsillectomy remains an important clinical problem despite advances in anesthetic and surgical techniques. This study investigated the effect of a one-day course of intravenous dexamethasone on recovery from tonsillectomy. PATIENTS AND METHODS:In a double-blind, randomize...

    journal_title:Annals of Saudi medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.5144/0256-4947.2004.365

    authors: Al-Shehri AM

    更新日期:2004-09-01 00:00:00

  • A comparative ultrasound and plain abdominal x-ray: Evaluation of non-classical clinical cases of appendicitis.

    abstract::A prospective study of 109 patients with non-classical symptoms of appendicitis using the standard ultrasound (US) machine and plain abdominal x-rays demonstrated that US was superior to plain x-ray with a sensitivitiy, specificity and overall accuracy of 89%, 96% and 91%, respectively as compared with plain x-ray wit...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1993.41

    authors: Makanjuola D,Al-Qasabi Q,Malabarey T

    更新日期:1993-01-01 00:00:00

  • Aberrant internal carotid artery in the middle ear.

    abstract::An aberrant internal carotid artery (ICA) in the middle ear space can present in 1% of the population. The clinical diagnosis can be difficult as most patients with this anomaly are either asymptomatic or have nonspecific clinical symptoms and signs. Moreover the diagnosis can easily be missed and only discov.ered whe...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.194

    authors: Alharethy S

    更新日期:2013-03-01 00:00:00

  • The patterns of oropharyngeal microflora in patients with homozygous sickle cell disease.

    abstract::A controlled prospective study was carried out between 16 July 1991 and 31 January 1992 to evaluate the oropharyngeal flora in homozygous sickle cell disease (SS). Throat swabs for cultures were taken from 163 asymptomatic SS patients attending sickle cell clinics (90 children and 73 adults). Throat swabs were also ta...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1995.215

    authors: Al-Dabbous IA,Al-Jam'a AH,El-Bashier AM

    更新日期:1995-05-01 00:00:00

  • Hepatitis C virus genotyping by polymerase chain reaction and DNA enzyme immunoassay among Saudi patients in the Western Province, Saudi Arabia.

    abstract:BACKGROUND:The distribution of hepatitis C virus (HCV) genotypes in the Western Province of Saudi Arabia is unknown. The purpose of our study was to determine the prevalent HCV genotypes among HCV seropositive Saudi patients in the Western Province, and to study the relationship between types/subtypes, clinical status ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2000.394

    authors: Osoba AO,Ibrahim M,Abdelaal MA,Al-Mowallad A,Al Shareef B,Hussein BA

    更新日期:2000-09-01 00:00:00

  • The relationship between markedly elevated glucose challenge test results and the rate of gestational diabetes mellitus and gestational impaired glucose tolerance.

    abstract:BACKGROUND AND OBJECTIVES:Even though the 50 g oral glucose challenge test (GCT) is the most commonly used screening modality for gestational diabetes mellitus (GDM), no consensus for the diagnostic approach is available to patients with a markedly elevated GCT result. We aimed to evaluate the diagnostic utility of mar...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2012.391

    authors: Karcaaltincaba D,Altinbas S,Akyol M,Ensari T,Yalvac S

    更新日期:2012-07-01 00:00:00

  • Familial clustering of type II diabetes mellitus (DM) diagnosed under the age of 40 years in Yemen: Is it early-onset type II DM or maturity-onset diabetes of the young?

    abstract:BACKGROUND:Clinical presentation of type II diabetes mellitus (DM) has frequently been observed at an early age in developing countries, probably as a result of genetic, epidemiological and demographic factors. This study aimed to investigate the pattern of familial clustering of type II DM in patients who developed cl...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1999.308

    authors: Gunaid AA

    更新日期:1999-07-01 00:00:00

  • Follicular thyroid carcinoma within a thyroglossal duct cyst in adult.

    abstract::Thyroglossal duct cyst carcinoma is a rare malignancy, with an incidence of 0.7% to 1.6%. Most cases of thyroglossal duct cyst carcinoma are papillary carcinoma, with follicular carcinoma having been rarely reported. In this study, a 33-year-old man presented with a typical thyroglossal duct cyst and underwent surgica...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2018.305

    authors: Bifari IN,Alherabi A,Alkaff H,Al-Arqen H,Jastania RA

    更新日期:2018-07-01 00:00:00

  • Prediction of low birth weight infants from ultrasound measurement of placental diameter and placental thickness.

    abstract:BACKGROUND:The aim of the study was to help to predict low birth weight infants by measuring placental diameter and thickness. SUBJECTS AND METHODS:A prospective study was conducted of 70 consecutive singleton pregnancies to evaluate placental diameter and thickness by ultrasonographic measurement at 36 weeks gestatio...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2002.312

    authors: Habib FA

    更新日期:2002-09-01 00:00:00

  • Appendiceal ascariasis in children.

    abstract:BACKGROUND:The propensity of Ascaris lumbricoides to wander leads to varied surgical complications in the abdomen. Wandering A lumbricoides may sometimes reach the vermiform appendix and its presence there may remain silent or incite pathology. Our aim was to study ascariadial appendicitis. METHODS:Over a period of 3 ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.4103/0256-4947.59380

    authors: Wani I,Maqbool M,Amin A,Shah F,Keema A,Singh J,Kitagawa M,Nazir M

    更新日期:2010-01-01 00:00:00

  • Q fever: a neglected zoonosis in Saudi Arabia.

    abstract:BACKGROUND AND OBJECTIVES:Infection due to Coxiella burnetii (C burnetii), the causative agent of Q fever is rarely sought for in clinical practice. This study was performed to detect C burnetii infection in patients with pyrexia of undetermined cause (PUC). DESIGN AND SETTINGS:This is a prospective study conducted at...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2013.464

    authors: Almogren A,Shakoor Z,Hasanato R,Adam MH

    更新日期:2013-09-01 00:00:00

  • A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly.

    abstract:BACKGROUND:Autosomal recessive primary microcephaly (MCPH) is a clinically and genetically heterogeneous disorder. Patients with MCPH exhibit reduced occipito-frontal head circumference and non-progressive intellectual disability. To date, 17 genes have been known as an underlying cause of MCPH in humans. ASPM (abnorma...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2016.391

    authors: Hashmi JA,Al-Harbi KM,Ramzan K,Albalawi AM,Mehmood A,Samman MI,Basit S

    更新日期:2016-11-01 00:00:00

  • Chronic spontaneous cervicothoracic epidural hematoma in an 8-month-old infant.

    abstract::Spontaneous spinal epidural hematoma is an uncommon cause of cord compression in children, especially in infants. An 8-month-old infant was admitted to our hospital for a 40-day history of paraparesis in the lower extremities. This rapidly progressed to paraparesis with an inability to move the lower extremities. MRI ...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.4103/0256-4947.75586

    authors: Min S,Duan Y,Jin A,Zhang L

    更新日期:2011-05-01 00:00:00

  • Risk factors of mental retardation in children attending an educationally subnormal/mental school in Dammam, Saudi Arabia.

    abstract::The objective of this case control study was no identify the possible associated risk factors of mild mental retardation in children. Sixty-nine parents of mildly mentally retarded (MR group) male children and a similar number of matched parents of normal male children (control) were interviewed using a questionnaire....

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.1993.355

    authors: Al-Dawood K,Albar A

    更新日期:1993-07-01 00:00:00

  • The value of CD34, myeloperoxidase and chloroacetate esterase (Leder) stain in the diagnosis of granulocytic sarcoma.

    abstract:BACKGROUND:The differentiation of extramedullary myelogenous leukemia/granulocytic sarcoma (GS) from malignant lymphoma can sometimes be difficult. In the current study, we explored the value of CD34, myeloperoxidase and nonspecific esterase (Leder) stains in differentiating GS from lymphomas. MATERIALS AND METHODS:Fi...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2001.287

    authors: Mourad W,Kfoury H,Al Husseini H

    更新日期:2001-09-01 00:00:00

  • Changing pattern of hepatitis viral infection in Saudi Arabia in the last two decades.

    abstract:BACKGROUND:Information on the epidemiology of viral hepatitis B, C and A in the Kingdom of Saudi Arabia (KSA) has accumulated over the last two decades. We review the changing epidemiology of these infections and suggest possible strategies for eradication. METHODS:We screened Saudi medical journals and Medline for re...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2003.367

    authors: Al-Faleh FZ

    更新日期:2003-11-01 00:00:00

  • Successful transfer from insulin to oral sulfonylurea in a 3-year-old girl with a mutation in the KCNJ11 gene.

    abstract::Neonatal diabetes mellitus is considered a rare disease that is diagnosed in the first six months of life, and can be either transient or permanent. Recent advances in molecular genetics have shown that activating mutations in KCNJ11 (the gene that encodes for the Kir6.2 subunit of the K ATP potassium channel of the p...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.4103/0256-4947.60526

    authors: Al-Mahdi M,Al Mutair A,Al Balwi M,Hussain K

    更新日期:2010-03-01 00:00:00

  • Thyroid surgery in 103 children in a single institution from 2000-2014.

    abstract:BACKGROUND:Data on thyroid surgery in children are scarce. OBJECTIVE:Analyze outcome data on thyroid surgery in a pediatric population. DESIGN:Medical record review. SETTING:Tertiary health care institution. PATIENTS AND METHODS:We collected demographic and clinical data on patients 18 years or younger who had thyr...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2020.316

    authors: Almosallam OI,Aseeri A,Alhumaid A,AlZahrani AS,Alsobhi S,AlShanafey S

    更新日期:2020-07-01 00:00:00

  • Peripheral neuropathy in thalassaemia.

    abstract:BACKGROUND:Patients with thalassemia may complain of numbness and weakness of the lower extremities. The aim of the study was to document whether these patients suffer from a polyneuropathy and to determine any contributing factors for the development of neuropathy. PATIENTS AND METHODS:We examined 30 patients with th...

    journal_title:Annals of Saudi medicine

    pub_type: 杂志文章

    doi:10.5144/0256-4947.2006.358

    authors: Sawaya RA,Zahed L,Taher A

    更新日期:2006-09-01 00:00:00