Abstract：
PURPOSE:The aim of this study was to assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers potentially influencing prognosis. METHODS:A total of 18 eyes of 18 patients with neovascular AMD were examined subsequent to completion of the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean period of 84 months (range 69-93 months). After receiving a loading dose of 3 intravitreal anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated as needed (pro re nata, PRN). Functional and morphological changes were assessed, the latter using spectral domain optical coherence tomography (SD-OCT). RESULTS:Retinal/RPE atrophy generally increased significantly during follow-up compared to baseline (fibrosis 28% vs. 89%, p = 0.0001, geographic atrophy, GA 0% vs. 67%, p = 0.0002, RPE porosity 61% vs. 100%, p = 0.009) whereas regenerative alterations tendentially increased until 3 months and then subsequently declined until the last visit (RPE thickening 28% vs. 11%, p = 0.22 and intraretinal hyperreflective foci 89% vs. 78%, p = 0.39). CONCLUSION:Atrophic alterations of the retina and RPE are progressive and may partly be induced by anti-VEGF. Morphological findings may aid in the identification of prognostic markers in the progression of neovascular AMD. This could lead to a more targeted education of affected patients.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Ebner C,Wernigg C,Schütze C,Weingessel B,Vécsei-Marlovits PVdoi
10.1007/s00508-020-01718-6subject
Has Abstractpub_date
2020-08-06 00:00:00eissn
0043-5325issn
1613-7671pii
10.1007/s00508-020-01718-6pub_type
杂志文章abstract：:In the course of routine gastroduodenoscopic examination of 218 patients bioptic mucosal specimens were examined bacteriologically for the presence of Campylobacter (C.) pylori. The organism was isolated from 52 out of 53 patients (98%) with duodenal ulcer, 7 out of 9 with gastric ulcer (78%), 24 out of 31 with mucosa...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1987-07-17 00:00:00
abstract：:Diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state (HHS) represent potentially life-threatening situations in adults. Therefore, rapid comprehensive diagnostic and therapeutic measures with close monitoring of vital and laboratory parameters are required. The treatment of DKA and HHS is essentially t...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/s00508-018-1423-z
更新日期：2019-05-01 00:00:00
abstract：:Peripheral M-mode contrast echocardiograms at rest and during the Valsalva manoeuvre were performed in 9 patients with haemodynamically insignificant interatrial communications. Contrast echoes appeared in the left heart in all 4 patients with elevated right ventricular pressure, but also in 3 out of the 5 patients wi...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1980-04-11 00:00:00
abstract：:Cervical re-exploration in persistent medullary thyroid cancer usually fails to normalize serum calcitonin levels, which is the most sensitive criterion of tumour-free status (2 out of 21 patients in our re-exploration series). Positive lymph nodes - even at an early tumour stage - seem much more important (postoperat...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1988-05-27 00:00:00
abstract：:Evidence demonstrates that medical diabetes treatment has to be accompanied by lifestyle modifications. Structured nutrition interventions and increased physical activity will help patients to normalise, respectively maintain their body weight. The main target of a diabetes therapy is aimed at achieving normal or near...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/s00508-015-0926-0
更新日期：2016-04-01 00:00:00
abstract：:The aims are presented and the technical equipment and application of different contrast media (barium sulphate and gas) are discussed. The steps of examination are divided into 5 phases. Thus, each part of the stomach is shown both by extreme filling and relief technique and by double contrast. The advantages and dis...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1979-05-25 00:00:00
abstract：:We present a case of spontaneous recanalization of the internal carotid artery (ICA) that occurred in a 51-year-old male patient. The occlusion of the right ICA was asymptomatic and was detected incidentally during imaging of the opposite carotid artery. The patient underwent neuroradiologic analysis and a tapered, fl...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-010-1490-2
更新日期：2010-11-01 00:00:00
abstract：:Because pulmonary embolism (PE) and its treatment carry substantial risk of morbidity and mortality, accurate diagnosis is essential. We report two cases with allergic reactions, in which PE was suggested by routine ECG and D-dimer elevation and strengthened by spiral CT. Therapy with low-molecular-weight heparin was ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/BF03040891
更新日期：2003-10-31 00:00:00
abstract：AIM:Sleep disordered breathing (SDB) is an inevitable complication of progressive neuromuscular disorders (NMD). Aim of the study was to prospectively investigate the impact of three months of non-invasive ventilation (NIV) on sleep and SDB-associated symptoms in children and adolescents with advanced NMD. METHODS:Twe...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/BF03040405
更新日期：2003-12-30 00:00:00
abstract：:Clinical and genetic investigations were performed on seven members of a family suffering from multiple hereditary fibromatosis. These studies indicate that the responsible gene appears to be coupled and transmitted with that of the rhesus system, located at chromosome one. The diagnosis, differential diagnosis and th...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1976-02-06 00:00:00
abstract：:A case of recurrent peroneal tendon subluxation is reported. Dynamic ultrasonography is the best imaging modality in the diagnosis of peroneal tendon subluxation. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-013-0435-y
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Prolonged pregnancy is the most frequent reason for induction of labor. This study aims to determine the effects of labor induction on delivery outcome and to quantify the risks of cesarean delivery associated with labor induction in post-date pregnancies. PATIENTS AND METHODS:This retrospective case-contro...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-005-0330-2
更新日期：2005-04-01 00:00:00
abstract：:Thirty four children, aged 2 to 15 years, were treated by haemodialysis between 1967 and 1978. Eleven children suffered from acute renal failure. Twenty three children with end-stage chronic renal disease were treated over periods ranging from 1 week to 19 months. All children were dialysed in a renal unit for adult p...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1980-01-18 00:00:00
abstract：:Antibodies to HHV-6 were detected by immunofluorescence in 8.04% of 460 healthy blood donors in West Austria. Testing sera from patients with acute or reactivated infections with other herpesviruses, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV) and varicella zoster virus (VZV) we...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1989-06-23 00:00:00
abstract：:Cryptosporidium is an important cause of community gastroenteritis, usually associated with drinking contaminated water, visits to swimming pools or animal exposure. In immunocompetent patients, cryptosporidiosis is usually a self-limiting disease but it can be devastating illness in immunocompromised persons. This re...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-006-0637-7
更新日期：2006-08-01 00:00:00
abstract：:An 84-year-old female patient was admitted to our internal medicine outpatient clinic complaining of stomach ache, nausea, and vomiting. She had hepatitis C infection for 10 years that was managed with antiviral treatment. On the second day of admission, she developed anxiety and complained about dysuria. Medazepam an...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-014-0523-7
更新日期：2014-05-01 00:00:00
abstract：:In a double-blind randomized trial 91 patients with endoscopically confirmed duodenal and/or prepyloric ulcers received either 1000 mg cimetidine daily (44 patients) or placebo (47 patients) for 4 weeks. At 2 weeks complete ulcer healing was significantly increased in patients receiving cimetidine (45%) in comparison ...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1979-01-19 00:00:00
abstract：:The serum hydroxyproline level enables a clinical assessment to be made of bone metabolism. A clinical-chemical method, which is described in detail, was applied in 50 control persons as well as in 76 patients with diseases of bones and/or joints. This method, which is a modification of the standard ion-exchange metho...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1981-03-06 00:00:00
abstract：BACKGROUND:The face is affected in more than 50% of patients with extensive burn trauma. Effective treatment is of importance to avoid hypertrophic scarring, functional impairment and social stigmatization. MATERIAL AND METHODS:All patients treated with Acticoat7™ due to superficial and deep partial thickness burns of...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-020-01757-z
更新日期：2020-10-30 00:00:00
abstract：:During routine anatomical dissection we found an unusual case of origin of the right bronchial artery from a common stem with the inferior thyroid artery, which arose from the internal thoracic artery. Anatomical variations of the origin of bronchial arteries are very frequent and numerous, and their recognition may b...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:In order to investigate the association of urinary excretion of sodium and potassium with blood pressure, 72 prepubertal healthy children between 8 and 9 years were investigated in a cross sectional study. We determined anthropometric data, diastolic (DBP), and systolic blood pressure (SBP) and urinary excretion of so...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Antibiotic concentrations in postoperative wound secretions and in serum give some indication of the local and general effects of an antibiotic additive to bone cement. Ten patients received hip endoprostheses using a prepacked mixture of the bone cement Sulfix 6 with neomycin + bacitracin (Sulfix 6 A). After operatio...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:This study analyses the efficacy of a consistent, strict follow-up programme in the management of patients with gastric cancer. Between 1978 and 1986 671 patients were treated, of whom 361 (54%) had a radical operation. The data were fed into an electronic data base and patients were invited to attend the follow-up in...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1987-06-12 00:00:00
abstract：UNLABELLED:Discussion of selection criteria for liver transplantation in alcoholics has been controversial. The concern that there might be a return to alcohol misuse after transplantation which would cause non-compliance with post-transplantation management is not supported by recent reports. Six months of abstinence ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:12 patients with chronic bronchitis were treated with two different doses (0.02 and 0.08 mg) of Sch 1000 (Atrovent) administered by metered dose inhalation and the results compared with those following administration of a placebo in a cross-over double-blind study. The airway resistance and thoracic gas volume fell si...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章
doi：
更新日期：1975-02-21 00:00:00
abstract：PURPOSE:Patients with localized prostate cancer are treated with 3D radiotherapy using a rectal balloon catheter for internal immobilization of the prostate, thereby reducing the radiation dose to the dorsal rectal wall. The purpose of the study was to investigate clinical feasibility and the influence of acute rectal ...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00508-006-0588-z
更新日期：2006-05-01 00:00:00
abstract：:The effect of oral administration of iodine brine as used in the Austrian health resort Bad Hall on 131I uptake in thyroid, skin and serum, and on the renal radioiodine excretion was studied in 22 rats. Intake of iodine brine resulted in a marked decrease of 131I uptake by the thyroid, both in the long-term experiment...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1989-11-24 00:00:00
abstract：:The case is reported of a patient in whom a granulosa cell tumour of the right ovary was removed at the age of 47 years. 14 years later the same type of tumour was found in the left ovary, together with an adenocarcinoma of the body of the uterus. 5 years after removal of these neoplasms splenectomy was carried out on...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1977-04-29 00:00:00
abstract：:Alcohol consumption is one of the most common causes of secondary hyperlipidaemia in man, but not all alcohol addicts display hyperlipidaemia. 10 healthy male controls were compared with three groups of patients. The first group consisted of 9 heavy drinkers exhibiting type V hyperlipidaemia under the influence of alc...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1985-03-29 00:00:00
abstract：:A critical review of the relevant literature revealed that the incidence of subarachnoid haemorrhage is increased in women taking oral contraceptives and the mortality rate is higher. The data concerning correlation between the use of oral contraceptives and other cerebrovascular disorders are less conclusive. Taking ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1986-05-16 00:00:00
