当前位置： SCI文献检索 > JOURNAL OF CLINICAL EPIDEMIOLOGY期刊下所有文献 > Measuring drug exposure: concordance between defined daily dose and days' supply depended on drug class.

Measuring drug exposure: concordance between defined daily dose and days' supply depended on drug class.

Abstract：

OBJECTIVES:To determine the concordance between two methods to measure drug exposure duration from pharmacy claim data. STUDY DESIGN AND SETTING:We conducted a cohort study using 2002-2007 US Medicaid data. Initiators of eight drug groups were identified: statins, metformin, atypical antipsychotics, warfarin, proton pump inhibitors (PPIs), angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs (ns-NSAIDs), and coxibs. For each patient, we calculated two measures of exposure duration using (1) observed days' supply available in US pharmacy claims and (2) the World Health Organisation's Defined Daily Dose (DDD) methodology. We used Wilcoxon signed rank tests to compare medians and Spearman correlations to assess correlation between the two measures. RESULTS:Cohort sizes ranged from 143,885 warfarin users to >3,000,000 ns-NSAID users. Similar median exposure durations were observed for ACE inhibitors (70 days vs.75 days), PPIs (44 days vs. 45 days), and coxibs (44 days vs. 45 days). The DDD method overestimated exposure duration for ns-NSAIDs and underestimated for the remaining drug groups, relative to days' supply. Spearman correlation coefficients ranged from 0.2 to 0.8. CONCLUSION:Using DDDs to estimate drug exposure duration can result in misclassification. The magnitude of this misclassification might depend on doses used which can vary according to factors such as local prescribing practices, renal function, and age.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Sinnott SJ,Polinski JM,Byrne S,Gagne JJ

doi

10.1016/j.jclinepi.2015.05.026

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

107-13

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(15)00273-5

journal_volume

69

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL EPIDEMIOLOGY文献大全
  • Likelihood and clinical trials.

    abstract：:The history of the application of statistical theory to the analysis of clinical trials is reviewed. The current orthodoxy is a somewhat illogical hybrid of the original theory of significance tests of Edgeworth, Karl Pearson, and Fisher, and the subsequent decision theory approach of Neyman, Egon Pearson, and Wald. T...

    journal_title：Journal of clinical epidemiology

    pub_type： 历史文章,杂志文章

    doi：10.1016/s0895-4356(99)00156-0

    authors： Hill G,Forbes W,Kozak J,MacNeill I

    更新日期：2000-03-01 00:00:00

  • Validation of the Danish Birth Registration.

    abstract：:We assessed validity and reliability of data on four serious pregnancy complications and gestational age in two national registers, the Medical Birth Register (MBR) and the National Register of Hospital Discharges (NRHD). From a cohort of all women in Denmark who gave birth to their first and second singleton infant i...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(96)00018-2

    authors： Kristensen J,Langhoff-Roos J,Skovgaard LT,Kristensen FB

    更新日期：1996-08-01 00:00:00

  • Diagnostic certainty and potential for misclassification in exocrine pancreatic cancer. PANKRAS I Project Investigations.

    abstract：:Whereas over the last decade epidemiologic studies on exocrine pancreatic cancer (EPC) continued to show a remarkable heterogeneity in diagnostic criteria applied to define caseness, the actual magnitude and consequences of misclassification remain largely unexplored. The objectives were: (1) to estimate the degree of...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(94)90123-6

    authors： Porta M,Malats N,Piñol JL,Rifà J,Andreu M,Real FX

    更新日期：1994-09-01 00:00:00

  • Variation in the duration of protection given by screening using the Pap test for cervical cancer.

    abstract：:The duration of protection offered by Pap screening for cervical cancer was examined using data on 101 cases of invasive cervical cancer and 396 controls from a Maryland case-control study. Receipt of a Pap test up to 4 years ago afforded significant protection, compared to women screened 11 or more years ago, or neve...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(89)90166-2

    authors： Klassen AC,Celentano DD,Brookmeyer R

    更新日期：1989-01-01 00:00:00

  • Reproducibility and relative validity of a self-administered semiquantitative food frequency questionnaire applied to younger women.

    abstract：:We have evaluated the reproducibility and relative validity of a semiquantitative food frequency questionnaire (FFQ) used in a prospective study of risk factors for cervical neoplasia. The questionnaire is a modified version of one developed and evaluated in a middle-aged Danish population. In the present study, 122 w...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(96)00379-4

    authors： Friis S,Kruger Kjaer S,Stripp C,Overvad K

    更新日期：1997-03-01 00:00:00

  • Neck trouble in machine operating, dynamic physical work and sedentary work: a prospective study on occupational and individual risk factors.

    abstract：:A prospective study on the effects of occupational and individual factors on neck trouble was carried out among 1832 men representing static work with whole-body vibration (machine operators), dynamic physical work (construction carpenters) and sedentary work (office workers). Neck trouble and occupational and individ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(94)90085-x

    authors： Viikari-Juntura E,Riihimäki H,Tola S,Videman T,Mutanen P

    更新日期：1994-12-01 00:00:00

  • A case-control evaluation of treatment efficacy: the example of magnesium sulfate prophylaxis against eclampsia in patients with preeclampsia.

    abstract：:Randomized trials are the optimal approach for evaluations of treatment efficacy but may not always be feasible. We study the adequacy of the case-control design in evaluating efficacy in a situation where the investigated therapy, namely the administration of magnesium sulfate for the prevention of eclampsia in patie...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(96)00421-0

    authors： Abi-Said D,Annegers JF,Combs-Cantrell D,Suki R,Frankowski RF,Willmore LJ

    更新日期：1997-04-01 00:00:00

  • Alcoholic beverages and breast cancer: some observations on published case-control studies.

    abstract：:We identified 38 case-control studies investigating possible associations between alcoholic beverage consumption and cancer of the female breast. Each study was characterized according to design features such as: control type (hospital or community based), risk factors controlled for, matching strategy, and statistica...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,评审

    doi：10.1016/0895-4356(94)90026-4

    authors： Roth HD,Levy PS,Shi L,Post E

    更新日期：1994-02-01 00:00:00

  • Comorbidity independently predicted death in older prostate cancer patients, more of whom died with than from their disease.

    abstract：OBJECTIVE:The purpose of this study was to examine the proportion of men who died from prostate cancer (PrCa) vs. with PrCa and assess the comorbid conditions associated with other-cause deaths. STUDY DESIGN AND SETTING:We identified all male decedents aged >/=65 years in Jefferson County, AL, in 1993-1995. By crossli...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2003.11.009

    authors： Fouad MN,Mayo CP,Funkhouser EM,Irene Hall H,Urban DA,Kiefe CI

    更新日期：2004-07-01 00:00:00

  • Comparison of methods for calculation and depiction of incidence infection rates in long-term care facilities.

    abstract：:Assessment of changes in endemic infections in health care facilities are often based on comparison of infection rates over time. This study compared two methods for calculating and depicting infection data at a hospital-based nursing home care unit. Prospective incidence surveillance of nursing home acquired infectio...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(88)90162-x

    authors： Schicker JM,Franson TR,Duthie EH Jr,LeClair SM

    更新日期：1988-01-01 00:00:00

  • Time trends in the treatment of acute myocardial infarction in Switzerland from 1986 to 1993: do they reflect the advances in scientific evidence from clinical trials?

    abstract：:Three acute coronary care surveys (1986, 1990, and 1993) were conducted in the Swiss region of Vaud-Fribourg on all men aged 25 to 64 years hospitalized for a definite myocardial infarction (218, 224, and 167 cases). Nearly all patients received anticoagulants and nitrates. The proportion of patients treated increased...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(98)00049-3

    authors： Bourquin MG,Wietlisbach V,Rickenbach M,Perret F,Paccaud F

    更新日期：1998-09-01 00:00:00

  • Asymptomatic peripheral arterial occlusive disease predicted cardiovascular morbidity and mortality in a 7-year follow-up study.

    abstract：OBJECTIVE:Asymptomatic peripheral arterial occlusive disease (PAOD) is a common atherosclerotic disorder among the elderly population. Scarce data are available on the risk of nonfatal and fatal cardiovascular diseases in these subjects. We investigated cardiovascular morbidity and mortality of asymptomatic PAOD subjec...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jclinepi.2003.09.003

    authors： Hooi JD,Kester AD,Stoffers HE,Rinkens PE,Knottnerus JA,van Ree JW

    更新日期：2004-03-01 00:00:00

  • Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.

    abstract：:Administrative databases are increasingly used for studying outcomes of medical care. Valid inferences from such data require the ability to account for disease severity and comorbid conditions. We adapted a clinical comorbidity index, designed for use with medical records, for research relying on International Classi...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(92)90133-8

    authors： Deyo RA,Cherkin DC,Ciol MA

    更新日期：1992-06-01 00:00:00

  • Inferential reproduction analysis demonstrated that "paracetamol for acute low back pain" trial conclusions were reproducible.

    abstract：OBJECTIVES:The aim of this study was to reanalyze and reinterpret data obtained in Paracetamol in Acute Low Back Pain (PACE), the first large randomized controlled trial evaluating the efficacy of paracetamol in acute low back pain, to assess the inferential reproducibility of the original conclusions. STUDY DESIGN AN...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jclinepi.2020.01.010

    authors： Schreijenberg M,Chiarotto A,Mauff KAL,Lin CC,Maher CG,Koes BW

    更新日期：2020-05-01 00:00:00

  • Potentially unnecessary and wasteful clinical trial research detected in cumulative meta-epidemiological and trial sequential analysis.

    abstract：OBJECTIVE:The objective was to estimate the presence and extent to which potentially unnecessary and therefore maybe wasteful clinical trials regarding relevant interventions and outcomes in major clinical areas had been conducted. STUDY DESIGN AND SETTING:From current Cochrane collaboration systematic reviews in majo...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2016.11.003

    authors： Storz-Pfennig P

    更新日期：2017-02-01 00:00:00

  • In network meta-analysis, most of the information comes from indirect evidence: empirical study.

    abstract：OBJECTIVES:Network meta-analysis (NMA) may produce more precise estimates of treatment effects than pairwise meta-analysis. We examined the relative contribution of network paths of different lengths to estimates of treatment effects. STUDY DESIGN AND SETTING:We analyzed 213 published NMAs. We categorized network shap...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2020.04.009

    authors： Papakonstantinou T,Nikolakopoulou A,Egger M,Salanti G

    更新日期：2020-08-01 00:00:00

  • Using the numerical method in 1836, James Jackson bridged French therapeutic epistemology and American medical pragmatism.

    abstract：OBJECTIVES:To review James Jackson's analysis of bloodletting among pneumonitis patients at the newly founded Massachusetts General Hospital, in which he implemented the numerical method advocated by Pierre-Charles-Alexandre Louis. STUDY DESIGN AND SETTING:The study sample included 34 cases of clinically diagnosed pne...

    journal_title：Journal of clinical epidemiology

    pub_type： 传,历史文章,杂志文章

    doi：10.1016/j.jclinepi.2014.10.013

    authors： Kahn LG,Morabia A

    更新日期：2015-04-01 00:00:00

  • Meaningful changes for the Oxford hip and knee scores after joint replacement surgery.

    abstract：OBJECTIVES:To present estimates of clinically meaningful or minimal important changes for the Oxford Hip Score (OHS) and the Oxford Knee Score (OKS) after joint replacement surgery. STUDY DESIGN AND SETTING:Secondary data analysis of the NHS patient-reported outcome measures data set that included 82,415 patients list...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2014.08.009

    authors： Beard DJ,Harris K,Dawson J,Doll H,Murray DW,Carr AJ,Price AJ

    更新日期：2015-01-01 00:00:00

  • Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors.

    abstract：OBJECTIVE:Mendelian randomization is a popular technique for assessing and estimating the causal effects of risk factors. If genetic variants which are instrumental variables for a risk factor are shown to be additionally associated with a disease outcome, then the risk factor is a cause of the disease. However, in man...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2015.08.001

    authors： Burgess S,Butterworth AS,Thompson JR

    更新日期：2016-01-01 00:00:00

  • Standardized physical examination protocol for low back disorders: feasibility of use and validity of symptoms and signs.

    abstract：:A standardized examination protocol was developed for the assessment of low back disorders in primary care. The protocol was found feasible in the occupational health service setting. The interexaminer repeatability between an occupational physician and an occupational physiotherapist was good for most items. The pred...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(97)00266-7

    authors： Viikari-Juntura E,Takala EP,Riihimäki H,Malmivaara A,Martikainen R,Jäppinen P

    更新日期：1998-03-01 00:00:00

  • Minimally important change was estimated for the Manchester-Oxford Foot Questionnaire after foot/ankle surgery.

    abstract：OBJECTIVES:To ascertain the smallest amounts of change for the three Manchester-Oxford Foot Questionnaire (MOXFQ) domains that are likely to be clinically meaningful and beyond measurement error for conditions affecting the foot/ankle. Estimates were compared with those from the Short-Form 36 (SF-36). STUDY DESIGN AND...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2014.01.003

    authors： Dawson J,Boller I,Doll H,Lavis G,Sharp R,Cooke P,Jenkinson C

    更新日期：2014-06-01 00:00:00

  • Time-dependent variability in repeated measurements of cholesterol levels: clinical implications for risk misclassification and intervention monitoring.

    abstract：:Intraindividual variability (IIV) in total cholesterol levels based on measurements taken 1 week apart is compared with an estimate based on measurements taken 2 years apart. Single-subject 95% confidence intervals around the mean of two repeated measurements were Xi +/- 21 and +/- 28 mg/dl, respectively, and Xi +/- 3...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(93)90115-h

    authors： Roeback JR,Cook JR,Guess HA,Heyse JF

    更新日期：1993-10-01 00:00:00

  • Use of goal attainment scaling in measuring clinically important change in cognitive rehabilitation patients.

    abstract：:Measuring the effectiveness of cognitive rehabilitation programs poses both conceptual and practical challenges. We compared several standardized outcome measures with goal attainment scaling (GAS) to assess their sensitivity to changes in health status in patients undergoing cognitive rehabilitation. GAS is a measure...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(97)00014-0

    authors： Rockwood K,Joyce B,Stolee P

    更新日期：1997-05-01 00:00:00

  • Systematic reviews reveal unrepresentative evidence for the development of drug formularies for poor and nonwhite populations.

    abstract：OBJECTIVE:To explore implications of using systematic drug class reviews to develop U.S. Medicaid drug formularies. We assess racial/ethnic, gender, and socioeconomic status (SES) concordance between Medicaid populations and studies synthesized in Drug Effectiveness Review Project (DERP) systematic reviews. STUDY DESI...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jclinepi.2009.01.009

    authors： Odierna DH,Bero LA

    更新日期：2009-12-01 00:00:00

  • Plasma fibrinogen and coronary risk factors: the Scottish Heart Health Study.

    abstract：:Plasma fibrinogen was measured in a sample of 8824 men and women aged 40-59 years participating in the Scottish Heart Health Study, and related to cardiovascular risk factors. Women had higher fibrinogen levels than men. In both sexes, multivariate analysis showed that fibrinogen was positively associated with age, sm...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(90)90075-z

    authors： Lee AJ,Smith WC,Lowe GD,Tunstall-Pedoe H

    更新日期：1990-01-01 00:00:00

  • Diagnostic interpretation of electrocardiograms in population-based research: computer program research physicians, or cardiologists?

    abstract：:We assessed the performance of diagnostic electrocardiogram (ECG) interpretation by the computer program MEANS and by research physicians, compared to cardiologists, in a physician-based study. To establish a strategy for ECG interpretation in health surveys, we also studied the diagnostic capacity of three scenarios:...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(97)00100-5

    authors： de Bruyne MC,Kors JA,Hoes AW,Kruijssen DA,Deckers JW,Grosfeld M,van Herpen G,Grobbee DE,van Bemmel JH

    更新日期：1997-08-01 00:00:00

  • Rasch analysis of the PedsQL: an increased understanding of the properties of a rating scale.

    abstract：OBJECTIVE:Traditionally, measures have been developed using classical test theory (CTT). This study examines the psychometrics of the PedsQL 4.0 Generic Core Scales (parent report) using a modern psychometric approach (i.e., Rasch analysis) to determine if further insight regarding the behavior of the measure can be ga...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jclinepi.2012.04.014

    authors： Amin L,Rosenbaum P,Barr R,Sung L,Klaassen RJ,Dix DB,Klassen A

    更新日期：2012-10-01 00:00:00

  • The quest for "power": contradictory hypotheses and inflated sample sizes.

    abstract：:To have the "power" of avoiding undersized clinical trials, the customary statistical strategy used in the past few decades is aimed at rejecting both a null stochastic hypothesis and a contradictory alternative hypothesis. This approach gives a trial the "power" to confirm the "insignificance" of differences much sma...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(98)00029-8

    authors： Feinstein AR,Concato J

    更新日期：1998-07-01 00:00:00

  • AHRQ series on complex intervention systematic reviews-paper 3: adapting frameworks to develop protocols.

    abstract：BACKGROUND:Once a proposed topic has been identified for a systematic review and has undergone a question formulation stage, a protocol must be developed that specifies the scope and research questions in detail and outlines the methodology for conducting the systematic review. RATIONALE:Framework modifications are of...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2017.06.013

    authors： Butler M,Epstein RA,Totten A,Whitlock EP,Ansari MT,Damschroder LJ,Balk E,Bass EB,Berkman ND,Hempel S,Iyer S,Schoelles K,Guise JM

    更新日期：2017-10-01 00:00:00

  • Differential recall as a source of bias in epidemiologic research.

    abstract：:Differential recall between compared groups is discussed most often in the context of case-control studies. Cases, compared to controls, are suspected of providing a more complete report of their true exposure to an hypothesized risk factor, thereby biasing upwards the estimate of its effect. The present paper describ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(90)90100-4

    authors： Neugebauer R,Ng S

    更新日期：1990-01-01 00:00:00