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Likelihood and clinical trials.

Abstract：

:The history of the application of statistical theory to the analysis of clinical trials is reviewed. The current orthodoxy is a somewhat illogical hybrid of the original theory of significance tests of Edgeworth, Karl Pearson, and Fisher, and the subsequent decision theory approach of Neyman, Egon Pearson, and Wald. This hegemony is under threat from Bayesian statisticians. A third approach is that of likelihood, stemming from the work of Fisher and Barnard. This approach is illustrated using hypothetical data from the Lancet articles by Bradford Hill, which introduced clinicians to statistical theory.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Hill G,Forbes W,Kozak J,MacNeill I

doi

10.1016/s0895-4356(99)00156-0

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

223-7

issue

3

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(99)00156-0

journal_volume

53

pub_type

历史文章,杂志文章

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