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Time-dependent variability in repeated measurements of cholesterol levels: clinical implications for risk misclassification and intervention monitoring.

Abstract：

:Intraindividual variability (IIV) in total cholesterol levels based on measurements taken 1 week apart is compared with an estimate based on measurements taken 2 years apart. Single-subject 95% confidence intervals around the mean of two repeated measurements were Xi +/- 21 and +/- 28 mg/dl, respectively, and Xi +/- 30 and +/- 40 mg/dl for a single measurement. Comparing these results with published estimates over varying time intervals shows a trend of decreasing IIV with shorter intervals, suggesting that confidence interval widths based on short-term repeated measurements and those based on longer-term repeated measurements may differ more than previously assumed. The practical consequences are that: (1) the level of misclassification inherent in the National Cholesterol Education Program (NCEP) guidelines may be less than had been estimated; and (2) reliable cholesterol reductions resulting from dietary or other interventions may be somewhat easier to detect. These findings have implications for the cost-effectiveness of cholesterol screening strategies and interventions to reduce cholesterol.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Roeback JR,Cook JR,Guess HA,Heyse JF

doi

10.1016/0895-4356(93)90115-h

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

1159-71

issue

10

eissn

0895-4356

issn

1878-5921

pii

0895-4356(93)90115-H

journal_volume

46

pub_type

杂志文章

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