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A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells.

Abstract：

:Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells.

journal_name

Mol Cell Probes

journal_title

Molecular and cellular probes

authors

Cho JH,Lee SC,Ha NR,Lee SJ,Yoon MY

doi

10.1016/j.mcp.2015.05.014

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

492-499

issue

6

eissn

0890-8508

issn

1096-1194

pii

S0890-8508(15)30010-4

journal_volume

29

pub_type

杂志文章

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