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Genomic structure of the EPHA1 receptor tyrosine kinase gene.

Abstract：

:Some receptor tyrosine kinase genes are mutated in inherited and somatically acquired human cancers. To permit mutational analysis, the complete genomic structure of the human EPHA1 gene on chromosome 7q34 was determined and oligonucleotide pairs were designed to amplify coding regions. The gene contains 18 exons, two more than the related tyrosine kinase, EPHB2. Presumed sequencing errors in the published cDNA sequence of EPHA1 were identified in exons 10 and 11. Availability of this information will facilitate mutational analysis of EPHA1.

journal_name

Mol Cell Probes

journal_title

Molecular and cellular probes

authors

Owshalimpur D,Kelley MJ

doi

10.1006/mcpr.1999.0228

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

169-73

issue

3

eissn

0890-8508

issn

1096-1194

pii

S0890-8508(99)90228-1

journal_volume

13

pub_type

杂志文章

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