Abstract：
BACKGROUND:Segmental vitiligo (SV) is characterized by a unilateral and localized distribution, early onset, and stable disease after rapid progression. And SV is often associated with poor response to various treatment modalities. OBJECTIVE:We sought to evaluate the effectiveness of combination therapy with 308-nm excimer laser, topical tacrolimus, and short-term systemic corticosteroids for SV, and to search for factors associated with the treatment response. METHODS:A retrospective interventional case-series study was performed on 159 patients with SV who were treated with the combination therapy for more than 3 months. RESULTS:The rate of 75% or more repigmentation was 50.3% after a median treatment duration of 12.1 months; 36.5% and 13.8% of the patients showed nearly complete (75%-99%) and complete (100%) repigmentation, respectively. Multivariable analysis showed the following to be independent factors with poor response: disease duration longer than 12 months (odds ratio 0.372, 95% confidence interval 0.157-0.882, P = .025), poliosis (odds ratio 0.494, 95% confidence interval 0.247-0.988, P = .046), and plurisegmental subtype (odds ratio 0.175, 95% confidence interval 0.065-0.474, P = .001). LIMITATIONS:This was a retrospective study. CONCLUSION:The combination therapy is effective for SV. Prolonged disease duration, poliosis, and plurisegmental subtype were shown to be independent prognostic factors of poor response in patients with SV.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Bae JM,Yoo HJ,Kim H,Lee JH,Kim GMdoi
10.1016/j.jaad.2015.04.008subject
Has Abstractpub_date
2015-07-01 00:00:00pages
76-82issue
1eissn
0190-9622issn
1097-6787pii
S0190-9622(15)01510-8journal_volume
73pub_type
杂志文章abstract：BACKGROUND:The current standard tool for diagnosing allergic contact dermatitis (ACD) in the United States is the T.R.U.E. test panels, which consist of 23 allergens. Previous studies have raised concern regarding the adequacy of these panels in fully assessing patients with possible ACD. OBJECTIVE:We sought to examin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2003.489
更新日期：2003-07-01 00:00:00
abstract：:We report a case of fatal pancreatitis heralded by the presence of cutaneous panniculitis without abdominal pain or other stigmata of the disease. Although cutaneous fat necrosis has been associated with pancreatitis, it is unusual as the presenting complaint of this relatively common disease. In vitro evidence sugges...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(87)70213-8
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abstract：BACKGROUND:While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss. OBJECTIVES:We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous...
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abstract：:Striking results were obtained with oral itraconazole therapy in two opportunistic mycoses. Of 28 patients with cryptococcal meningitis, 18 achieved complete responses, including 16 of 24 patients with acquired immunodeficiency syndrome. Other manifestations of cryptococcosis were similarly responsive. In aspergillosi...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/0190-9622(90)70262-g
更新日期：1990-09-01 00:00:00
abstract：:Juvenile xanthogranuloma is a histiocytic tumor that usually appears at birth or during the first year of life. Although most patients have solitary lesions, some have multiple cutaneous lesions, associated visceral lesions, or both. Although juvenile xanthogranulomas are usually confined to the skin; visceral involve...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2007.09.012
更新日期：2008-02-01 00:00:00
abstract：:Vulvar melanosis is a condition in which intensely pigmented irregular macules, clinically mimicking malignant melanoma, appear on the vulva. A biopsy specimen shows only marked lower epidermal pigmentation without any melanocytic atypia or nesting. The process is benign, and reassurance is the only treatment. ...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/0190-9622(90)70319-d
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:Few data exist on the relationship between psoriasis and melanocytic lesions. OBJECTIVES:We sought to investigate number of melanocytic nevi in psoriatic patients compared with control subjects and its relationship with disease severity and treatment. METHODS:We performed a prospective study in 189 psoriat...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2013.08.017
更新日期：2013-12-01 00:00:00
abstract：:We present the case of an American adult patient with eosinophilic pustular folliculitis. The majority of previously reported patients have been Japanese. Eosinophilic pustular folliculitis is a rare condition characterized by recurrent, peripherally expanding, sterile papulopustules and plaques. Hair-bearing areas su...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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更新日期：1986-01-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(89)70248-6
更新日期：1989-10-01 00:00:00
abstract：BACKGROUND:Early studies using HIV protease inhibitors (PI) showed regression of Kaposi's sarcoma (KS) lesions in some patients. OBJECTIVE:Our purpose was to determine prospectively the influence of PI on HIV-related KS. METHODS:KS lesions of nine patients with progressive cutaneous disease were prospectively evaluat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70124-0
更新日期：1998-04-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1067/mjd.2001.116340
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(83)70146-5
更新日期：1983-09-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(03)02801-9
更新日期：2004-01-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1067/mjd.2003.219
更新日期：2003-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(98)70377-9
更新日期：1998-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.01.860
更新日期：2014-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(94)70096-6
更新日期：1994-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：2011-03-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(89)70094-3
更新日期：1989-05-01 00:00:00
abstract：:A recent familial case of hereditary epidermolytic palmoplantar keratoderma (Vörner type) that was treated with orally administered etretinate is reported herein. A review of the literature with regard to the clinical, genetic, and laboratory features of this rare genodermatosis is also presented. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(87)70222-9
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:Although an association between antihistaminic drugs and atypical cutaneous lymphoid infiltrates has not been reported previously, in vitro evidence suggests that these agents perturb certain lymphoid functions through binding to histamine receptors, including a novel growth-promoting intracellular histamine...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(95)90063-2
更新日期：1995-03-01 00:00:00
