Abstract：
:There is a high incidence of Campylobacter pylori in the gastric mucosa of patients with duodenal ulcer, gastric ulcer, and nonulcer dyspepsia. Factors that lead to development of this infection are unknown. We hypothesized that delayed solid-phase gastric emptying, a condition characterized by antral stasis, might predispose to Campylobacter pylori infection. We prospectively studied 51 patients with symptoms of gastroparesis using a solid-phase gastric emptying study and upper endoscopy. Patients were excluded if they had predominant symptoms of epigastric pain or an abnormal endoscopy. Three biopsies were obtained from the antrum and stained with H&E. When any inflammation was present, a Warthin-Starry stain was also performed. These were blindly examined for chronic inflammation, activity, and presence of Campylobacter pylori. Campylobacter pylori was not more common in patients with gastroparesis, documented by delayed gastric emptying, than in patients with a normal emptying study. On the contrary, there was a significantly lower incidence of Campylobacter pylori in those with delayed emptying compared to those with normal emptying (5% vs 31%, P less than 0.05). Gastritis activity correlated closely with Campylobacter presence. Inactive chronic gastritis with Campylobacter was equally common in those with delayed or normal gastric emptying. Diabetics were no more likely to harbor Campylobacter pylori than nondiabetics (16% vs 25%). The 5% incidence of Campylobacter in the gastroparesis group is less than, but approaches, that previously reported in asymptomatic controls. The 31% incidence of Campylobacter in the group with symptoms of gastroparesis but normal gastric emptying approaches that reported for nonulcer dyspepsia. Our data suggest that gastroparesis does not predispose to Campylobacter pylori infection or histologic chronic gastritis.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Barnett JL,Behler EM,Appelman HD,Elta GHdoi
10.1007/BF01540043subject
Has Abstractpub_date
1989-11-01 00:00:00pages
1677-80issue
11eissn
0163-2116issn
1573-2568journal_volume
34pub_type
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF02065410
更新日期：1995-02-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1994-09-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1981-03-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1987-01-01 00:00:00
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更新日期：1996-08-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1985-10-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1985-02-01 00:00:00
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更新日期：1996-07-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01318419
更新日期：1984-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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