Abstract：
:Toll-like receptor 2 (TLR2), a member of the Toll-like receptor family, plays an important role in the recognition of and subsequent immune response activation against leptospirosis in humans. The genetic polymorphism in TLR2 of an arginine to glutamine substitution at residue 753 (Arg753Gln) has been associated with a negative influence on TLR2 function, which may, in turn, determine the innate host response to Leptospira spp. This bacterium signals through TLR2/TLR1 heterodimers in human cells. The aim of the present study was to investigate the Arg753Gln single-nucleotide polymorphism (SNP) of the TLR2 gene, and the isoleucine to serine transversion at position 602 (Ile602Ser) of the TLR1 gene (previously associated with Lyme disease), in leptospirosis patients compared to healthy controls, carrying out a retrospective case/control study. The TLR2 polymorphism adenine (A) allele was observed in 7.3% of leptospirosis patients but was not found in the control group, whereas the guanine (G) allele of the TLR1 polymorphism was found in 63.6% of patients and 41.6% of controls. Susceptibility to leptospirosis disease was increased 10.57-fold for carriers of the TLR2 G/A genotype (P=0.0493) and 3.85-fold for carriers of the TLR1 G/G genotype (P=0.0428). Furthermore, the risk of developing hepatic insufficiency and jaundice was increased 18.86- and 27.60-fold for TLR2 G/A carriers, respectively. Similarly, the risk of developing jaundice was increased 12.67-fold for TLR1 G allele carriers (G/G and T/G genotypes). In conclusion, the present data suggest that the TLR2 Arg753Gln and TLR1 Ile602Ser SNPs influence the risk of developing leptospirosis and its severity.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Cédola M,Chiani Y,Pretre G,Alberdi L,Vanasco B,Gómez RMdoi
10.1016/j.actatropica.2015.03.007subject
Has Abstractpub_date
2015-06-01 00:00:00pages
73-80eissn
0001-706Xissn
1873-6254pii
S0001-706X(15)00055-8journal_volume
146pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：BACKGROUND:Dengue incidence has grown dramatically around the world in recent years. Vector control is the only method to reduce dengue incidence due to the lack of a vaccine available. By understanding the factors contributed to the vector densities such as environmental and sociological factors, dengue prevention and...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2021.105834
更新日期：2021-01-21 00:00:00
abstract：:The present study was undertaken to characterize more thoroughly aetiological agent of cystic echinococcosis that still represents a health problem in the Slovak Republic. Sequencing of the mitochondrial ND1 gene, Random Amplified Polymorphic DNA (RAPD) analysis and isoenzyme analyses were used to characterize genetic...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(02)00229-2
更新日期：2003-02-01 00:00:00
abstract：:Ultracytochemistry of polysaccharides and specific sugar residues reveals differences in the surface staining pattern between developmental forms of Trypanosoma brucei. The techniques used were the PA (periodic acid)-TCH (thiocarbohydrazide)-silver albumose reaction for the polysaccharides, and the Concanavalin A (Con...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:The presentation of the World Health Organization (WHO)'s roadmap for neglected tropical diseases (NTDs) in January 2012 raised optimism that many NTDs can indeed be eliminated. To make this happen, the endemic, often low-income countries with still heavy NTD burdens must substantially strengthen their health systems....
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.09.017
更新日期：2015-01-01 00:00:00
abstract：:In addition to genetic history, environmental conditions during larval stages are critical to the development, success and phenotypic fate of the Aedes aegypti mosquito. In particular, previous studies have shown a strong genotype-by-environment component to adult mosquito body size in response to optimal vs stressed ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.06.018
更新日期：2017-10-01 00:00:00
abstract：:The pathological events in human cerebral malaria are mimicked in the experimental cerebral malaria (ECM) in Plasmodium berghei ANKA (PBA)-infected C57BL/6 mice. Although previously implied in ECM, the kinetics of cytokines and chemokines expression-an essential functional feature for defining causality in ECM develop...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.04.025
更新日期：2017-08-01 00:00:00
abstract：:The present study performed an analysis of the ultrastructural changes induced by andiroba seed oil in the synganglion of Rhipicephalus sanguineus female ticks, aiming to provide scientific grounds to help in the creation of more specific and efficient methods of control. The synganglion consists of a mass of fused ne...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.06.018
更新日期：2015-01-01 00:00:00
abstract：:> Qualitative research methods were used in rural and urban areas of the Greater Accra Region to generate data to describe the folk diagnosis, etiology and management of malaria. Respondents defined as fever a set of symptoms loosely concordant with clinical malaria. Primary cause of fever as heat and particularly in ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(94)90025-6
更新日期：1994-12-01 00:00:00
abstract：:As strictly haematophagous insects, tsetse flies feed on a wide variety of wild and domestic animals. Although these are mainly mammals, some tsetse species also feed on reptiles. The present study investigated whether the odours of several potential natural tsetse hosts may be used as novel attractants to improve the...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00083-1
更新日期：1997-11-01 00:00:00
abstract：:The trypanocidal activity of two commercially available isometamidium-based products, Samorin (Merial, USA) and Veridium (Sanofi Santé Nutrition Animale, France), used at a dose rate of 0.5 mg kg(-1) bodyweight, was compared in a field trial involving groups of approximately 30 zebu cattle in a trypanosomosis endemic ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(00)00132-7
更新日期：2000-11-02 00:00:00
abstract：:Macrophage Migration Inhibitory Factor (MIF) is the first human cytokine reported and was thought to have a central role in the regulation of inflammatory responses. Homologs of this molecule have been reported in bacteria, invertebrates and plants. Apart from cytokine activity, it also has two catalytic activities vi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.09.017
更新日期：2016-01-01 00:00:00
abstract：:Exposure of 2 day old virgin females of Glossina fuscipes fuscipes, G. pallidipes, G. brevipalpis, and G. morsitans centralis to carbon dioxide anaesthesia for 15 sec has the effect of suppressing their subsequent insemination frequency. This insemination-inhibitory effect of the gas is more pronounced in G. f. fuscip...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Parenteral quinine is the most frequently used first line treatment for severe Plasmodium falciparum malaria in the developed world. Quinine is known to have a number of toxic side effects including cardiotoxicity, ototoxicity and ocular toxicity. Many therefore advocate routine monitoring of quinine levels for patien...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2005.11.006
更新日期：2006-02-01 00:00:00
abstract：:Greece has been recently affected by several mosquito borne diseases with the West Nile Virus (WNV) outbreak in 2010 being one of the largest reported in Europe. Currently at the epicenter of an economic and refugee crisis and visited by over 16 million tourists a year the integrated management of diseases transmitted...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.06.005
更新日期：2017-10-01 00:00:00
abstract：:Bait-trapping is a useful approach for monitoring fly population dynamics, and it is an effective tool for physical control of pest species. The aim of this study was to test a newly developed semi-automatic funnel fly trap with some modifications of the former prototype fly trap to study medically important fly popul...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.07.018
更新日期：2017-12-01 00:00:00
abstract：:Trypanosoma rangeli, a non-pathogenic hemoflagelate that in Central and South America infects humans, shares with Trypanosoma cruzi reservoirs and triatomine vectors, as well as geographical distribution. Recently, we have described in T. rangeli a truncated gene copy belonging to the group II of the trans-sialidase s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.05.003
更新日期：2009-09-01 00:00:00
abstract：:Malaria in pregnancy is associated with increased risks of maternal anemia, spontaneous abortion, low birth weight, premature delivery and other adverse effects on health. In Brazil, disease transmission is highly concentrated in the multi-state region that constitutes the Brazilian Amazon (more than 99% of all cases)...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.11.004
更新日期：2013-02-01 00:00:00
abstract：:Diagnosis of neurocysticercosis (NCC) is complicated because of the variability in clinical presentations and course of the disease where viability of parasite is a major determinant. The present study describes evaluation of ELISAs using Taenia solium metacestode somatic and excretory-secretory (ES) antigens for dete...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.01.002
更新日期：2009-04-01 00:00:00
abstract：:Sodium Antimony Gluconate (SAG) is currently used worldwide as the first-line drugs for the treatment of visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) since 1940s. Unfortunately, the resistance of Leishmania parasite to this drug is increasing in several parts of the world. The mechanism of drug resista...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.01.005
更新日期：2009-04-01 00:00:00
abstract：:The clinicoepidemiologic profile of 143 cases (93 males and 50 females) with cutaneous leishmaniasis from 18 villages of Hajjah governorate, Yemen was studied. Dry-type lesions were seen in 98.6% and wet-type lesions in 1.4% of patients. Lesions were localized in all cases with different morphological patterns. Micros...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.08.012
更新日期：2016-11-01 00:00:00
abstract：:Four strains of Trypanosoma cruzi (Y, BG, M and Peru) retain their ability to infect Rhodnius prolixus and to produce virulent infections in mice for from 12 to 39 years. About 60 or more metacyclic trypomastigotes were consistently lethal to mice. The mean number of metacyclics per bug ranged from 1.2 to 17.3 x 10(3)...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Since 1988, the Sultanate of Oman has experienced three outbreaks of paralytic poliomyelitis. The last outbreak occurred in December 1993 and involved two children aged 10 months and 4 1/2 years. The children had received five and four doses, respectively, of trivalent oral polio vaccine (OPV) and lived in the same vi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(01)00166-8
更新日期：2001-10-22 00:00:00
abstract：:House is the major site for malaria infection where most human-vector contact takes place. Hence, improving housing might reduce the risk of malaria infection by limiting house entry of vectors. This study aimed to explore the impact of screening doors and windows with wire meshes on density and entomological inoculat...
journal_title：Acta tropica
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.actatropica.2018.02.009
更新日期：2018-05-01 00:00:00
abstract：:Leishmaniasis is a major vector-borne disease and health problem in Iran. Studies on sand flies, as the vectors of the disease, began in the Northern and Western parts of the country in 1930 and have been continued up to now. Concerning many published information in the field of sand flies, providing a digital databas...
journal_title：Acta tropica
pub_type： 杂志文章,meta分析
doi：10.1016/j.actatropica.2014.01.004
更新日期：2014-04-01 00:00:00
abstract：:In Argentina, American Cutaneous Leishmaniasis (ACL) extends up to 29°S in the phytogeographic regions of the Yungas (west), Chaco (center) and Paranaense (east). Since the Phlebotominae vectors of this disease in the western Chaco (dry Chaco) are unknown, in the present work, we studied the natural infection in Phleb...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.04.008
更新日期：2012-08-01 00:00:00
abstract：:Bay 44-4400 was used as a spot on formulation and administered in single doses of 25 and 100 mg/kg to Acanthocheilonema viteae, Brugia malayi, and Litomosoides sigmodontis infected Mastomys coucha on various dates during prepatency, aiming to affect third stage larvae, fourth stage larvae or preadult worms. Microfilar...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(01)00144-9
更新日期：2001-09-01 00:00:00
abstract：:Anti-T. dionisii and anti-T. vespertilionis monoclonal antibodies secreted by 17 hybridoma clones were tested against various strains of T. dionisii, T. vespertilionis, T. cruzi and T. cruzi marinkellei. Strain and species specific antigens were detected for the homologous immunizing strains. The common antigenic dete...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:The prevalence of schistosomiasis due to S. japonicum is focally high in the lake regions of China, and reinfection after treatment with praziquantel is frequent. In this study, the total reinfection rate among 740 treated persons was 12.9%. Factors associated with reinfection were age and sex, water contact and the d...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(93)90053-e
更新日期：1993-08-01 00:00:00
abstract：:A quantitative framework is presented for the site-specific characterization of schistosomiasis transmission with the object of developing local control strategies. Central to the framework is a worm-burden model using ordinary differential equations of disease transmission in risk groups defined by residence and occu...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/s0001-706x(02)00018-9
更新日期：2002-05-01 00:00:00
abstract：:In vitro cultured Plasmodium falciparum gametocytes were fed to Anopheles gambiae (G3) mosquitoes to identify parasite population characteristics useful for predicting successful mosquito infections. Parameters were collected from an initial study of 90 infections over a two year period and a second study of 55 infect...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(94)90117-1
更新日期：1994-10-01 00:00:00
