Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells.


:The present study has examined the effects of adenosine A1 receptors on second messenger processes in GH3 cells. A1 receptors are present which are shown to inhibit adenylate cyclase in a GTP-requiring manner. Hormone (VIP) stimulation is also absolutely required for the observation of inhibition. Adenosine A1 receptor analogues also inhibit TRH-stimulated [Ca2+]i-mobilization in GH3 cells. Both effects of the adenosine receptor agonists are apparently mediated by pertussis toxin substrates, of which there are two--41,000 and 40,000 daltons respectively--in these cells. Somatostatin exerts analogous effects to the adenosine agonists in GH3 cells. Thus it may turn out that a general property of 'cyclase inhibitory receptors' is also to inhibit [Ca2+]i-mobilization in the same cells, when such mechanisms are present.


Cell Signal


Cellular signalling


Cooper DM,Caldwell KK,Boyajian CL,Petcoff DW,Schlegel W




Has Abstract


1989-01-01 00:00:00














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    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Kikuchi A

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    authors: Rojas-Morales P,Tapia E,Pedraza-Chaverri J

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    journal_title:Cellular signalling

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    authors: Warner DR,Okuya S,Rebois RV

    更新日期:1996-01-01 00:00:00

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    authors: Funakoshi-Tago M,Tago K,Kasahara T,Parganas E,Ihle JN

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    authors: Yan D,Quan H,Wang L,Liu F,Liu H,Chen J,Cao X,Ge B

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    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Wang X,Liu Y

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    authors: Nieto Gutierrez A,McDonald PH

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    authors: Wu J,Liang Y,Tan Y,Tang Y,Song H,Wang Z,Li Y,Lu M

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    authors: Hanke S,Valkova C,Stirnweiss J,Drube S,Liebmann C

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    journal_title:Cellular signalling

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    journal_title:Cellular signalling

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    authors: Mintzer KA,Field J

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    journal_title:Cellular signalling

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    journal_title:Cellular signalling

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    journal_title:Cellular signalling

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    authors: Kang MS,Ahn KH,Kim SK,Jeon HJ,Ji JE,Choi JM,Jung KM,Jung SY,Kim DK

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  • Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549.

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    journal_title:Cellular signalling

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    authors: Fang L,Min L,Lin Y,Ping G,Rui W,Ying Z,Xi W,Ting H,Li L,Ke D,Jihong R,Huizhong Z

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    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Ilsley JL,Sudol M,Winder SJ

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  • Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.

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    journal_title:Cellular signalling

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    authors: Han S,Zhu T,Ding S,Wen J,Lin Z,Lu G,Zhang Y,Xiao W,Ding Y,Jia X,Chen H,Gong W

    更新日期:2020-12-01 00:00:00

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    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Yu M,Zhan J,Zhang H

    更新日期:2020-02-01 00:00:00

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    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Rabiee A,Krüger M,Ardenkjær-Larsen J,Kahn CR,Emanuelli B

    更新日期:2018-07-01 00:00:00

  • Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.

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    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Matsuhashi S,Hamajima H,Xia J,Zhang H,Mizuta T,Anzai K,Ozaki I

    更新日期:2014-03-01 00:00:00

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    abstract::The HMG-box protein 1 (HBP1) is a transcriptional regulator and a potential tumor suppressor that controls cell proliferation, differentiation and oncogene-mediated senescence. In a previous study, we showed that AKT activation through the PI3K/AKT/FOXO pathway represses HBP1 expression at the transcriptional level in...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Bollaert E,Johanns M,Herinckx G,de Rocca Serra A,Vandewalle VA,Havelange V,Rider MH,Vertommen D,Demoulin JB

    更新日期:2018-04-01 00:00:00