Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells.


:The present study has examined the effects of adenosine A1 receptors on second messenger processes in GH3 cells. A1 receptors are present which are shown to inhibit adenylate cyclase in a GTP-requiring manner. Hormone (VIP) stimulation is also absolutely required for the observation of inhibition. Adenosine A1 receptor analogues also inhibit TRH-stimulated [Ca2+]i-mobilization in GH3 cells. Both effects of the adenosine receptor agonists are apparently mediated by pertussis toxin substrates, of which there are two--41,000 and 40,000 daltons respectively--in these cells. Somatostatin exerts analogous effects to the adenosine agonists in GH3 cells. Thus it may turn out that a general property of 'cyclase inhibitory receptors' is also to inhibit [Ca2+]i-mobilization in the same cells, when such mechanisms are present.


Cell Signal


Cellular signalling


Cooper DM,Caldwell KK,Boyajian CL,Petcoff DW,Schlegel W




Has Abstract


1989-01-01 00:00:00














  • Lysophospholipids and chemokines activate distinct signal transduction pathways in T helper 1 and T helper 2 cells.

    abstract::We demonstrate the expression of S1P(1,3,4,5) the receptors for sphingosine 1-phosphate (S1P), and LPA(1,2,3) the receptors for lysophosphatidic acid (LPA) in T helper 1 (Th1) and T helper 2 (Th2) cells. S1P and LPA induce the chemotaxis of Th1 and Th2 cells, an activity that is resistant to pertussis toxin (PTX) pret...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Wang L,Knudsen E,Jin Y,Gessani S,Maghazachi AA

    更新日期:2004-09-01 00:00:00

  • Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.

    abstract::Insulin is an inducer of brown fat adipogenesis through the activation of a signalling network that involves positive/negative modulators. Given the importance of brown adipose tissue (BAT) for basal thermogenic energy expenditure, we investigated the role of PTP1B in the acquisition of terminal differentiated phenoty...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Miranda S,González-Rodríguez A,Revuelta-Cervantes J,Rondinone CM,Valverde AM

    更新日期:2010-04-01 00:00:00

  • The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.

    abstract::SHP-2, a cytosolic protein tyrosine phosphatase with two SH2 domains and multiple tyrosine phosphorylation sites, contributes to signal transduction as an enzyme and/or adaptor molecule. Here we demonstrate that prolactin (PRL) stimulation of the PRL-responsive Nb2 cells, a rat lymphoma cell line, and T47D cells, a hu...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Minoo P,Chughtai N,Campiglio M,Stein-Gerlach M,Lebrun JJ,Ullrich A,Ali S

    更新日期:2003-03-01 00:00:00

  • Different phosphorylated forms of inositolphosphate glycan could be involved in the transforming growth factor-beta 1 (TGF-beta 1) signalling pathway.

    abstract::Labelling with [3H]glucosamine was used to prepare a transforming growth factor-beta 1 (TGF-beta 1)-sensitive glycosylphosphatidylinositol (GPI) from monolayer cultures of rabbit articular chondrocytes (RAC), which may be involved in control of the cell cycle. The polar headgroup of this glycosylphosphatidylinositol w...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Vivien D,Bogdanowicz P,Boumediene K,Martiny L,Haye B,Pujol JP

    更新日期:1994-02-01 00:00:00

  • Tyrosine kinase-independent activation of extracellular-regulated kinase (ERK) 1/2 by the insulin-like growth factor-1 receptor.

    abstract::The extracellular-regulated kinase (ERK1/2) is a key conduit for transduction of signals from growth factor receptors to the nucleus. Previous work has shown that ERK1/2 activation in response to IGF-1 may require the participation of G proteins, but the role of the receptor tyrosine kinase in this process has not bee...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Perrault R,Wright B,Storie B,Hatherell A,Zahradka P

    更新日期:2011-04-01 00:00:00

  • S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA2 phosphorylation.

    abstract::Both sphingosine-1-phosphate receptor-2 (S1PR2) and cytosolic phospholipase A2 (cPLA2) are implicated in the disruption of cerebrovascular integrity in experimental stroke. However, the role of S1PR2 in induction of cPLA2 phosphorylation during cerebral ischemia-induced endothelial dysfunction remains unknown. This st...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Cao C,Dai L,Mu J,Wang X,Hong Y,Zhu C,Jin L,Li S

    更新日期:2019-01-01 00:00:00

  • Leukotriene D4 induced calcium changes in U937 cells may utilize mechanisms additional to inositol phosphate production that are pertussis toxin insensitive but are blocked by phorbol myristate acetate.

    abstract::DMSO differentiated U937 cells responded to 10(-6) M LTD4, LTB4 and FMLP with an increase in both InsP formation and [Ca2+]i. FMLP caused a greater rise in InsPs than either LTD4 or LTB4, which were equivalent. LTD4, however, caused a greater increase in [Ca2+]i than LTB4 (4-fold) or FMLP. The FMLP [Ca2+]i and InsP re...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Pollock K,Creba J

    更新日期:1990-01-01 00:00:00

  • Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer.

    abstract::Proteoglycans (PGs) represent a large proportion of the components that constitute the extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a covalent link to a specific glycosaminoglycan type. As part of the ECM, heparan sulfate (HS)PGs participate in both physiological and pathologi...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Hassan N,Greve B,Espinoza-Sánchez NA,Götte M

    更新日期:2021-01-01 00:00:00

  • Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance.

    abstract::Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. However the relative role of each pathway and how they interact are not understood. Here we delineate how Akt and Rac1 pathways signal to increa...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Sylow L,Kleinert M,Pehmøller C,Prats C,Chiu TT,Klip A,Richter EA,Jensen TE

    更新日期:2014-02-01 00:00:00

  • CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.

    abstract::Tyrosine phosphorylation (Tyr-P) of focal adhesion kinase (FAK) regulates FAK activation. Phosphorylated FAK Tyr 397 binds Src family kinases (Src), which in turn directly phosphorylate FAK Tyr 576/577 to produce maximal FAK enzymatic activity. CB₁ cannabinoid receptors (CB₁) are abundantly expressed in the nervous sy...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Dalton GD,Peterson LJ,Howlett AC

    更新日期:2013-08-01 00:00:00

  • The role of sphingosine-1-phosphate in smooth muscle contraction.

    abstract::Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that is known to mediate diverse cellular responses including cell growth, survival, and migration. Most of these effects have been attributed to its binding to a specific subfamily of G protein-coupled receptors (GPCR), namely S1P(1-5). Recent studi...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Watterson KR,Ratz PH,Spiegel S

    更新日期:2005-03-01 00:00:00

  • CaMKIIδ interacts directly with IKKβ and modulates NF-κB signalling in adult cardiac fibroblasts.

    abstract::Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease. Activation of CaMKIIδ is also known to regulate cardiovascular inflammation and is reported to be required for pro-inflammatory NF-κB signalling. In this...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Martin TP,McCluskey C,Cunningham MR,Beattie J,Paul A,Currie S

    更新日期:2018-11-01 00:00:00

  • A crosstalk between TGF-β/Smad3 and Wnt/β-catenin pathways promotes vascular smooth muscle cell proliferation.

    abstract:RATIONALE:Endovascular interventions performed for atherosclerotic lesions trigger excessive vascular smooth muscle cell (SMC) proliferation leading to intimal hyperplasia. Our previous studies show that following endovascular injury, elevated TGF-β/Smad3 promotes SMC proliferation and intimal hyperplasia. Furthermore ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: DiRenzo DM,Chaudhary MA,Shi X,Franco SR,Zent J,Wang K,Guo LW,Kent KC

    更新日期:2016-05-01 00:00:00

  • The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes.

    abstract::The protective effect of Regulator of G protein Signaling 2 (RGS2) in cardiac hypertrophy is thought to occur through its ability to inhibit the chronic GPCR signaling that promotes pathogenic growth both in vivo and in cultured cardiomyocytes. However, RGS2 is known to have additional functions beyond its activity as...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Chidiac P,Sobiesiak AJ,Lee KN,Gros R,Nguyen CH

    更新日期:2014-06-01 00:00:00

  • Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairments. The classical symptoms of the disease include gradual deterioration of memory and language. Epidemiological studies indicate that around 25-40% of AD patients have sleep-wake cycle disturbances. Importantly, a series of st...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Havekes R,Heckman PRA,Wams EJ,Stasiukonyte N,Meerlo P,Eisel ULM

    更新日期:2019-12-01 00:00:00

  • The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line.

    abstract::Monoamine oxidase-A (MAO-A) dysfunction has been historically associated with depression. Recently, depression as well as altered MAO-A expression have both been associated with a poor prognosis in cancers, although the mechanism involved remains ambiguous. For example, MAO-A mRNA is repressed across cancers, yet MAO-...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Satram-Maharaj T,Nyarko JN,Kuski K,Fehr K,Pennington PR,Truitt L,Freywald A,Lukong KE,Anderson DH,Mousseau DD

    更新日期:2014-12-01 00:00:00

  • Difference between follistatin isoforms in the inhibition of activin signalling: activin neutralizing activity of follistatin isoforms is dependent on their affinity for activin.

    abstract::We demonstrate the difference between the follistatin isoforms (FS-288 and FS-315), two activin-binding proteins, in the neutralizing activity for activin signalling. Transcriptional reporter assay using 3TP-Lux, an activin-responsive reporter construct, showed that the inhibitory effect of FS-288 on activin-induced t...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Hashimoto O,Kawasaki N,Tsuchida K,Shimasaki S,Hayakawa T,Sugino H

    更新日期:2000-08-01 00:00:00

  • Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells.

    abstract::Slug, a Snail-related zinc-finger transcription factor implicated in the increased motility of mesenchymal cells during embryonic development and progression of cancer cells towards an invasive phenotype, plays a specific and critical role in the pathogenesis of Bcr-Abl-associated leukemias. Here we report that Slug o...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Mancini M,Petta S,Iacobucci I,Salvestrini V,Barbieri E,Santucci MA

    更新日期:2010-08-01 00:00:00

  • Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

    abstract::Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N morphologically resembles inflammation-inducing pyroptosis - cell destruction triggered by activated caspase-1. The treatment with A + N (or camptothecin) strongly upregulat...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Krześniak M,Zajkowicz A,Gdowicz-Kłosok A,Głowala-Kosińska M,Łasut-Szyszka B,Rusin M

    更新日期:2020-05-01 00:00:00

  • D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase.

    abstract::β-Adrenergic receptors (βAR) and D(2)-like dopamine receptors (which include D(2)-, D(3)- and D(4)-dopamine receptors) activate G(s) and G(i), the stimulatory and inhibitory heterotrimeric G proteins, respectively, which in turn regulate the activity of adenylyl cyclase (AC). β(2)-Adrenergic receptors (β(2)AR) and D(4...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Rebois RV,Maki K,Meeks JA,Fishman PH,Hébert TE,Northup JK

    更新日期:2012-11-01 00:00:00

  • The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.

    abstract::By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Hoa L,Kulaberoglu Y,Gundogdu R,Cook D,Mavis M,Gomez M,Gomez V,Hergovich A

    更新日期:2016-05-01 00:00:00

  • Akt signalling in health and disease.

    abstract::Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1, Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the mechanisms by which Akt isoforms are activated by growth factors and other extracellular stimuli as well as by oncogenic mutations in key upstrea...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Hers I,Vincent EE,Tavaré JM

    更新日期:2011-10-01 00:00:00

  • Mechanism of phospholipase D activation induced by prostaglandin D2 in osteoblast-like cells: function of Ca2+/calmodulin.

    abstract::Prostaglandin D2 (PGD2) stimulated the formation of choline in a dose-dependent manner in the range between 10 nM and 10 microM. The effect of PGD2 on the formation of inositol phosphates (EC50 was 20 nM) was more potent than that on the formation of choline (EC50 was 0.5 microM). The formation of choline stimulated b...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Imamura Y,Kozawa O,Suzuki A,Watanabe Y,Saito H,Oiso Y

    更新日期:1995-01-01 00:00:00

  • Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells.

    abstract::The small GTPase Rac1 plays a pivotal role in insulin-stimulated glucose uptake in skeletal muscle, which is mediated by GLUT4 translocation to the plasma membrane. However, regulatory mechanisms for Rac1 and its role in the signaling pathway composed of phosphoinositide 3-kinase and the serine/threonine kinase Akt re...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Nozaki S,Takeda T,Kitaura T,Takenaka N,Kataoka T,Satoh T

    更新日期:2013-06-01 00:00:00

  • Insulin-induced cell division is controlled by the adaptor Grb14 in a Chfr-dependent manner.

    abstract::Beyond its key role in the control of energy metabolism, insulin is also an important regulator of cell division and neoplasia. However, the molecular events involved in insulin-driven cell proliferation are not fully elucidated. Here, we show that the ubiquitin ligase Chfr, a checkpoint protein involved in G2/M trans...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Perdereau D,Cailliau K,Browaeys-Poly E,Lescuyer A,Carré N,Benhamed F,Goenaga D,Burnol AF

    更新日期:2015-04-01 00:00:00

  • Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area.

    abstract::Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins, and that the Ser 824 residue of TRPV4 is phosphorylated by SGK1. In this study, ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Shin SH,Lee EJ,Hyun S,Chun J,Kim Y,Kang SS

    更新日期:2012-03-01 00:00:00

  • Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis.

    abstract::The proteins Bax and Bak are central in the execution phase of apoptosis; however, little is known about the partners involved in the control of this complex process. Here, we show that mitochondrial Bak is incorporated into a VDAC2/Mtx1/Mtx2 multi-protein complex in both resting and dying cells. VDAC2 is a porin that...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Cartron PF,Petit E,Bellot G,Oliver L,Vallette FM

    更新日期:2014-09-01 00:00:00

  • Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

    abstract::Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and psoriatic arthritis. However, little is known on the expression patter...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

    更新日期:2016-07-01 00:00:00

  • Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function.

    abstract::Persistent exposure to ambient fine particulate matter (PM2.5) can exacerbate allergic diseases in humans. Mast cells play an important role in allergic inflammation in peripheral tissues, such as skin, mucosa, and lung. Engagement of the high-affinity Fc receptor leads to mast cell degranulation, releasing a variety ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Jin Y,Zhu M,Guo Y,Foreman D,Feng F,Duan G,Wu W,Zhang W

    更新日期:2019-05-01 00:00:00

  • Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.

    abstract::In diverse neuronal processes ranging from neuronal survival to synaptic plasticity cyclic adenosine monophosphate (cAMP)-dependent signaling is tightly connected with the protein kinase B (PKB)/Akt pathway but the precise nature of this connection remains unknown. In the current study we investigated the effect of tw...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Nijholt IM,Dolga AM,Ostroveanu A,Luiten PG,Schmidt M,Eisel UL

    更新日期:2008-10-01 00:00:00