Abstract:
:The present study has examined the effects of adenosine A1 receptors on second messenger processes in GH3 cells. A1 receptors are present which are shown to inhibit adenylate cyclase in a GTP-requiring manner. Hormone (VIP) stimulation is also absolutely required for the observation of inhibition. Adenosine A1 receptor analogues also inhibit TRH-stimulated [Ca2+]i-mobilization in GH3 cells. Both effects of the adenosine receptor agonists are apparently mediated by pertussis toxin substrates, of which there are two--41,000 and 40,000 daltons respectively--in these cells. Somatostatin exerts analogous effects to the adenosine agonists in GH3 cells. Thus it may turn out that a general property of 'cyclase inhibitory receptors' is also to inhibit [Ca2+]i-mobilization in the same cells, when such mechanisms are present.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Cooper DM,Caldwell KK,Boyajian CL,Petcoff DW,Schlegel Wdoi
10.1016/0898-6568(89)90023-5subject
Has Abstractpub_date
1989-01-01 00:00:00pages
85-97issue
1eissn
0898-6568issn
1873-3913pii
0898-6568(89)90023-5journal_volume
1pub_type
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